Adra1b adrenergic receptor, alpha 1b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adra1bprovided by MGI
Official Full Name: adrenergic receptor, alpha 1bprovided by MGI
Primary source: MGI:MGI:104774
See related: Ensembl:ENSMUSG00000050541 AllianceGenome:MGI:104774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: [a]1b
Summary: Enables alpha1-adrenergic receptor activity. Involved in multicellular organism aging; neuron-glial cell signaling; and regulation of blood pressure. Acts upstream of or within several processes, including positive regulation of blood pressure; regulation of glycogen catabolic process; and response to alkaloid. Is integral component of membrane. Is expressed in central nervous system; heart; retina; and testis. Orthologous to human ADRA1B (adrenoceptor alpha 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 44.6), heart adult (RPKM 12.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 25.81 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (43665432..43792076, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (43774605..43901250, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, these results suggested that alpha1B-adrenoceptor signaling is required for bone formation and regulated cellular proliferation through a mechanism relevant to the up-regulation of CCAAT/enhancer-binding protein delta in osteoblasts and, thus, provide new evidence for the physiological importance of alpha1B-adrenoceptor signalling in bone homeostasis
Title: α1B -Adrenoceptor signalling regulates bone formation through the up-regulation of CCAAT/enhancer-binding protein δ expression in osteoblasts.
eIF3f/alpha adrenergic receptor interaction
Title: The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity.
The adra1b mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium
Title: The α₁B -adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium.
in mouse ureters: the mRNA for the alpha1A-adrenoceptor was more prevalent than those for the alpha1B- and alpha1D-adrenoceptors
Title: Gene expressions and mechanical functions of α1-adrenoceptor subtypes in mouse ureter.
This is the first study to demonstrate that alpha(1A)- and alpha(1B)-ARs differentially modulate antidepressant-like behavior in the mouse.
Title: alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse.
Data provide strong evidence for a pathological role of chronic alpha(1B)-AR activity in the development of repolarization defects and ventricular arrhythmias.
Title: Electrical remodeling in a transgenic mouse model of alpha1B-adrenergic receptor overexpression.
Alpha 1b-adrenergic receptor (alpha 1b-AR) plays a fundamental role in the mechanisms responsible for seizure onset, severity, and duration, whereas the brain damage observed in alpha 1b-AR-overexpressing mice is likely to be a secondary phenomenon.
Title: Lack of alpha 1b-adrenergic receptor protects against epileptic seizures.
Nuclear alpha1B-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.
Title: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.
Alpha 1b-AR signaling plays a critical role in the control of male fertility, spermatogenesis, and steroidogenic capacityof Leydig cells.
Title: Fertility and spermatogenesis are altered in {alpha}1b-adrenergic receptor knockout male mice.
These results demonstrate that alpha(1)-adrenoceptors, particularly alpha(1A)-adrenoceptors, are required for normal contractility of the vas deferens and consequent sperm ejaculation as well as having a function in fertility
Title: Alpha1-adrenoceptors are required for normal male sexual function.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha1-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha1-adrenergic receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables alpha1-adrenergic receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha1-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adult heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell growth involved in cardiac muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron-glial cell signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within organ growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to morphine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to steroid hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-1B adrenergic receptor

Names: alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha1B-adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284380.1 → NP_001271309.1 alpha-1B adrenergic receptor

See identical proteins and their annotated locations for NP_001271309.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK043877, BY107791, CA319459

Consensus CDS

CCDS24562.1

UniProtKB/Swiss-Prot

P97717

UniProtKB/TrEMBL

Q9DBL0

Related

ENSMUSP00000123435.2, ENSMUST00000139906.2

Conserved Domains (1) summary

cd15326
Location:46 → 359

7tmA_alpha1B_AR; alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001284381.1 → NP_001271310.1 alpha-1B adrenergic receptor

See identical proteins and their annotated locations for NP_001271310.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK004891, AK043877, BY107791, CA319459

Consensus CDS

CCDS24562.1

UniProtKB/Swiss-Prot

P97717

UniProtKB/TrEMBL

Q9DBL0

Related

ENSMUSP00000070200.3, ENSMUST00000067258.9

Conserved Domains (1) summary

cd15326
Location:46 → 359

7tmA_alpha1B_AR; alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_007416.4 → NP_031442.2 alpha-1B adrenergic receptor

See identical proteins and their annotated locations for NP_031442.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AK043877, AK139448, CA319459

Consensus CDS

CCDS24562.1

UniProtKB/Swiss-Prot

P97717

UniProtKB/TrEMBL

Q9DBL0

Related

ENSMUSP00000129200.2, ENSMUST00000167574.2

Conserved Domains (1) summary

cd15326
Location:46 → 359

7tmA_alpha1B_AR; alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

43665432..43792076 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248675.4 → XP_011246977.1 alpha-1B adrenergic receptor isoform X1

See identical proteins and their annotated locations for XP_011246977.1

UniProtKB/Swiss-Prot

P97717

UniProtKB/TrEMBL

Q9DBL0

Conserved Domains (1) summary

cd15326
Location:46 → 359

7tmA_alpha1B_AR; alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors