Adora2b adenosine A2b receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adora2bprovided by MGI
Official Full Name: adenosine A2b receptorprovided by MGI
Primary source: MGI:MGI:99403
See related: Ensembl:ENSMUSG00000018500 AllianceGenome:MGI:99403
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A2b; A2BR; A2BAR; AA2BR; ARA2B
Summary: Enables G protein-coupled receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including positive regulation of cGMP-mediated signaling; positive regulation of chronic inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is active in synapse. Is expressed in several structures, including cardiovascular system; central nervous system; eye; genitourinary system; and gut. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 18.0), bladder adult (RPKM 15.8) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (62139810..62157278)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (62248984..62266452)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adenosine A2B receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia.
Title: Adenosine A(2B) receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia.
Klotho Null Mutation Involvement in Adenosine A2B Receptor-Related Skeletal Muscle Degeneration.
Title: Klotho Null Mutation Involvement in Adenosine A2B Receptor-Related Skeletal Muscle Degeneration.
Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
Title: Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
Title: CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1.
Title: Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1.
Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
Title: Adenosine A(2B) receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
Title: Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming.
Title: Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming.
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling.
Title: PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling.
Membrane cholesterol oxidation downregulates atrial beta-adrenergic responses in ROS-dependent manner.
Title: Membrane cholesterol oxidation downregulates atrial β-adrenergic responses in ROS-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (117)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

AI605384 (e-PCR)
- UniSTS:180225

AI480866 (e-PCR)
- UniSTS:165766

NoName (e-PCR)
- UniSTS:493256

Adora2b (e-PCR), detects polymorphism
- UniSTS:141042

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled adenosine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of catecholamine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chronic inflammatory response to non-antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of guanylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within relaxation of vascular associated smooth muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to angiotensin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adenosine receptor A2b

Names: A2b, Rs

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007413.4 → NP_031439.2 adenosine receptor A2b

See identical proteins and their annotated locations for NP_031439.2

Status: VALIDATED

Source sequence(s)

AL596110

Consensus CDS

CCDS24822.1

UniProtKB/Swiss-Prot

Q60614, Q8BXI2

UniProtKB/TrEMBL

Q8BK41

Related

ENSMUSP00000018644.3, ENSMUST00000018644.3

Conserved Domains (2) summary

pfam00001
Location:24 → 290

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:17 → 134

7tm_4; Olfactory receptor