GBP5 guanylate binding protein 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GBP5provided by HGNC
Official Full Name: guanylate binding protein 5provided by HGNC
Primary source: HGNC:HGNC:19895
See related: Ensembl:ENSG00000154451 MIM:611467; AllianceGenome:HGNC:19895
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GBP-5
Summary: This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Expression: Biased expression in appendix (RPKM 33.2), lymph node (RPKM 19.8) and 11 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p22.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (89256189..89272860, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (89099549..89116218, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (89721872..89738543, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice.
Title: Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice.
Guanylate binding protein 5 triggers NF-kappaB activation to foster radioresistance, metastatic progression and PD-L1 expression in oral squamous cell carcinoma.
Title: Guanylate binding protein 5 triggers NF-κB activation to foster radioresistance, metastatic progression and PD-L1 expression in oral squamous cell carcinoma.
Guanylate-binding protein 5-mediated cell-autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study.
Title: Guanylate-binding protein 5-mediated cell-autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study.
Whole blood GBP5 protein levels in patients with and without active tuberculosis.
Title: Whole blood GBP5 protein levels in patients with and without active tuberculosis.
GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis.
Title: GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis.
Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
Title: Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway.
Title: GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway.
Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis.
Title: Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis.
GBP5 Is an Interferon-Induced Inhibitor of Respiratory Syncytial Virus.
Title: GBP5 Is an Interferon-Induced Inhibitor of Respiratory Syncytial Virus.
Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.
Title: Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 assembly is restricted by GBP5 in HEK293T cells, SupT1 cells, primary PBMC, and macrophages as shown through mutational analysis (C583), overexpression, and siRNA knockdown of GBP5	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Nef may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of guanylate binding protein 5 (GBP5) in human primary T cells	PubMed
Vif	vif	HIV-1 Vif downregulates the expression of guanylate binding protein 5 (GBP5) in Vif-expression T cells	PubMed
Vpr	vpr	Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpr may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1	PubMed
Vpu	vpu	Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular function inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytolysis in another organism	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of AIM2 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-18 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of pyroptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in symbiont cell surface	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanylate-binding protein 5

Names: GBP-TA antigen; GTP-binding protein 5; guanine nucleotide-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052816.2 RefSeqGene

Range

5000..21671

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001134486.4 → NP_001127958.1 guanylate-binding protein 5 isoform 1

See identical proteins and their annotated locations for NP_001127958.1

Status: REVIEWED

Source sequence(s)

AC099063

Consensus CDS

CCDS722.1

UniProtKB/Swiss-Prot

B2RCE1, Q86TM5, Q96PP8

UniProtKB/TrEMBL

E7ETN8

Conserved Domains (2) summary

pfam02263
Location:18 → 280

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:282 → 574

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001391920.1 → NP_001378849.1 guanylate-binding protein 5 isoform 2

Status: REVIEWED

Source sequence(s)

AC099063

UniProtKB/TrEMBL

E7ETN8

Related

ENSP00000403010.1, ENST00000443807.1

Conserved Domains (2) summary

pfam02263
Location:18 → 280

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:282 → 454

GBP_C; Guanylate-binding protein, C-terminal domain
NM_052942.5 → NP_443174.1 guanylate-binding protein 5 isoform 1

See identical proteins and their annotated locations for NP_443174.1

Status: REVIEWED

Source sequence(s)

AC099063

Consensus CDS

CCDS722.1

UniProtKB/Swiss-Prot

B2RCE1, Q86TM5, Q96PP8

UniProtKB/TrEMBL

E7ETN8

Related

ENSP00000359488.3, ENST00000370459.8

Conserved Domains (2) summary

pfam02263
Location:18 → 280

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:282 → 574

GBP_C; Guanylate-binding protein, C-terminal domain