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Gpr182 G protein-coupled receptor 182 [ Mus musculus (house mouse) ]

Gene ID: 11536, updated on 5-Mar-2024

Summary

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Official Symbol
Gpr182provided by MGI
Official Full Name
G protein-coupled receptor 182provided by MGI
Primary source
MGI:MGI:109545
See related
Ensembl:ENSMUSG00000058396 AllianceGenome:MGI:109545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NOW; AM-R; Admr; MB10; G10-D; Gpcr17; Gpcr22
Summary
Predicted to enable adrenomedullin receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; gut; heart; reproductive system; and retina. Orthologous to human GPR182 (G protein-coupled receptor 182). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 41.9), spleen adult (RPKM 27.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 75.07 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127585471..127587667, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127749602..127751798, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene tachykinin 2 Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene STARR-seq mESC enhancer starr_28236 Neighboring gene retinol dehydrogenase 1 (all trans) Neighboring gene retinol dehydrogenase 9 Neighboring gene STARR-seq mESC enhancer starr_28237

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis. Le Mercier A, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33875597, Free PMC Article
  2. Adrenomedullin in mammalian embryogenesis. Garayoa M, et al. Microsc Res Tech, 2002 Apr 1. PMID 11921355
  3. Adrenomedullin expression in the mouse mammary gland: evidence for the mature form in milk. Jahnke GD, et al. J Mol Endocrinol, 1997 Dec. PMID 9460649
  4. Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action. Montuenga LM, et al. Endocrinology, 1997 Jan. PMID 8977434
  5. Cloning and expression of cDNA encoding a rat adrenomedullin receptor. Kapas S, et al. J Biol Chem, 1995 Oct 27. PMID 7592696

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity.
    Title: GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity.
  2. Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
    Title: Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
  3. ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment
    Title: The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables adrenomedullin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 182
Names
G10D
adrenomedullin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007412.2 → NP_031438.2  G-protein coupled receptor 182

    See identical proteins and their annotated locations for NP_031438.2

    Status: VALIDATED

    Source sequence(s)
    BB806742, BC125279, BY121440, BY590401
    Consensus CDS
    CCDS36084.1
    UniProtKB/Swiss-Prot
    P43142
    UniProtKB/TrEMBL
    G3X9R9
    Related
    ENSMUSP00000100882.3, ENSMUST00000079692.6
    Conserved Domains (1) summary
    cd14988
    Location:50 → 327
    7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127585471..127587667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43142.1 GenPept UniProtKB/Swiss-Prot:P43142

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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