Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcyap1r1provided by MGI
Official Full Name: adenylate cyclase activating polypeptide 1 receptor 1provided by MGI
Primary source: MGI:MGI:108449
See related: Ensembl:ENSMUSG00000029778 AllianceGenome:MGI:108449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAC1; PAC1R; PACAP1-R; 2900024I10Rik
Summary: Predicted to enable G protein-coupled peptide receptor activity; enzyme binding activity; and peptide binding activity. Predicted to be involved in several processes, including activation of phospholipase C activity; cAMP-mediated signaling; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including bicellular tight junction; caveola; and rough endoplasmic reticulum. Predicted to be part of receptor complex. Predicted to be active in neuron projection and plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; heart ventricle; nervous system; and testis. Orthologous to human ADCYAP1R1 (ADCYAP receptor type I). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 14.0), CNS E18 (RPKM 9.5) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.38 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (55428486..55478440)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (55451501..55501455)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAC1 receptor modulation of freezing and flight behavior in periaqueductal gray.
Title: PAC1 receptor modulation of freezing and flight behavior in periaqueductal gray.
Knockdown of PAC1 improved inflammatory pain in mice by regulating the RAGE/TLR4/NF-kappaB signaling pathway.
Title: Knockdown of PAC1 improved inflammatory pain in mice by regulating the RAGE/TLR4/NF-κB signaling pathway.
PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.
Title: PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.
Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis.
Title: Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis.
PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.
Title: PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.
PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy.
Title: PAC1 Receptor Mediates Electroacupuncture-Induced Neuro and Immune Protection During Cisplatin Chemotherapy.
A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear.
Title: A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear.
PAC1, rather than VPAC2, plays the principal role in mediating the cardiorespiratory effects of PACAP in response to hypoxic stress during neonatal development. Defective PACAP signaling via PAC1 may contribute to the pathogenesis of SIDS.
Title: Impaired neonatal cardiorespiratory responses to hypoxia in mice lacking PAC1 or VPAC2 receptors.
PACAP/PAC1 signaling is important for light regulated behavior, VIP/VPAC2 signaling for stable clock function and both signaling pathways may play a role in shaping diurnality versus nocturnality.
Title: PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice.
Its signaling evokes long-lasting nociceptive behaviors through the activation of spinal astrocytes.
Title: Pituitary adenylate cyclase-activating polypeptide type 1 receptor signaling evokes long-lasting nociceptive behaviors through the activation of spinal astrocytes in mice.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC315446P1 (e-PCR)
- UniSTS:272954

AI846590 (e-PCR)
- UniSTS:164324

Adcyap1r1 (e-PCR), detects polymorphism
- UniSTS:546535

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables vasoactive intestinal polypeptide receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: pituitary adenylate cyclase-activating polypeptide type I receptor

Names: PACAP type I receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025372.2 → NP_001020543.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001020543.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AI843743, AK083108, BC067039, BY286680, CA316040

Consensus CDS

CCDS20166.1

UniProtKB/TrEMBL

Q6NXJ9, Q8BGA4

Related

ENSMUSP00000066902.6, ENSMUST00000070756.12

Conserved Domains (2) summary

cd15987
Location:150 → 417

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 137

HRM; Hormone receptor domain
NM_007407.4 → NP_031433.3 pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_031433.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI843743, AK083108, BC067039, BY286680, CA320747

Consensus CDS

CCDS20167.1

UniProtKB/Swiss-Prot

P70205

UniProtKB/TrEMBL

Q8BLT3

Related

ENSMUSP00000063784.6, ENSMUST00000070736.12

Conserved Domains (2) summary

cd15987
Location:150 → 445

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 137

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

55428486..55478440

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241150.1 → XP_011239452.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

See identical proteins and their annotated locations for XP_011239452.1

UniProtKB/TrEMBL

E9PVE8

Conserved Domains (2) summary

cd15987
Location:150 → 472

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 137

HRM; Hormone receptor domain
XM_030255114.1 → XP_030110974.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X7

UniProtKB/TrEMBL

E9Q3E8, Q8BGA4

Conserved Domains (2) summary

cd15987
Location:129 → 396

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 116

HRM; Hormone receptor domain
XM_036165754.1 → XP_036021647.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X4

UniProtKB/TrEMBL

E9Q4B3, Q8BLT3

Related

ENSMUSP00000129614.2, ENSMUST00000165857.8

Conserved Domains (2) summary

cd15987
Location:150 → 445

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 137

HRM; Hormone receptor domain
XM_011241152.3 → XP_011239454.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X5

UniProtKB/TrEMBL

E9Q968, Q8BLT3

Related

ENSMUSP00000130923.2, ENSMUST00000165786.2

Conserved Domains (2) summary

cd15987
Location:150 → 444

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 137

HRM; Hormone receptor domain
XM_011241151.3 → XP_011239453.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2

UniProtKB/TrEMBL

E9PVE8

Conserved Domains (2) summary

cd15987
Location:129 → 451

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 116

HRM; Hormone receptor domain
XM_011241153.3 → XP_011239455.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X7

UniProtKB/TrEMBL

E9Q3E8, Q8BGA4

Related

ENSMUSP00000127319.2, ENSMUST00000172084.8

Conserved Domains (2) summary

cd15987
Location:129 → 396

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 116

HRM; Hormone receptor domain
XM_006505388.4 → XP_006505451.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

See identical proteins and their annotated locations for XP_006505451.1

UniProtKB/TrEMBL

E9PVE8

Related

ENSMUSP00000126994.2, ENSMUST00000167234.8

Conserved Domains (2) summary

cd15987
Location:150 → 472

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 137

HRM; Hormone receptor domain
XM_030255112.2 → XP_030110972.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X3

UniProtKB/Swiss-Prot

P70205

UniProtKB/TrEMBL

Q8BLT3

Conserved Domains (2) summary

cd15987
Location:150 → 445

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 137

HRM; Hormone receptor domain
XM_030255113.2 → XP_030110973.1 pituitary adenylate cyclase-activating polypeptide type I receptor isoform X6

UniProtKB/TrEMBL

Q6NXJ9, Q8BGA4

Conserved Domains (2) summary

cd15987
Location:150 → 417

7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:52 → 137

HRM; Hormone receptor domain