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Adam7 a disintegrin and metallopeptidase domain 7 [ Mus musculus (house mouse) ]

Gene ID: 11500, updated on 11-Apr-2024

Summary

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Official Symbol
Adam7provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 7provided by MGI
Primary source
MGI:MGI:107247
See related
Ensembl:ENSMUSG00000022056 AllianceGenome:MGI:107247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAP1; EAPI; ADAM 7
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is specifically expressed in epididymis where the encoded protein is transferred to the sperm surface during epididymal transit. This gene is located adjacent to a related gene from the ADAM family of proteins on chromosome 14. [provided by RefSeq, Oct 2015]
Expression
Restricted expression toward genital fat pad adult (RPKM 292.3) See more
Orthologs
human all
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Genomic context

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See Adam7 in Genome Data Viewer
Location:
14 D1; 14 35.69 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (68734785..68771138, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (68497336..68533689, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22319 Neighboring gene STARR-seq mESC enhancer starr_37042 Neighboring gene STARR-seq mESC enhancer starr_37043 Neighboring gene STARR-positive B cell enhancer mm9_chr14:68910779-68911080 Neighboring gene STARR-seq mESC enhancer starr_37045 Neighboring gene STARR-seq mESC enhancer starr_37046 Neighboring gene predicted gene, 41190 Neighboring gene predicted gene, 31227 Neighboring gene STARR-seq mESC enhancer starr_37047 Neighboring gene predicted gene, 41191 Neighboring gene ADAM-like, decysin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane. Oh JS, et al. Mol Cells, 2009 Nov 30. PMID 19855936
  2. Cloning and characterization of a complementary DNA encoding a human epididymis-associated disintegrin and metalloprotease 7 protein. Lin YC, et al. Biol Reprod, 2001 Sep. PMID 11514362
  3. Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Choi H, et al. Biol Reprod, 2015 Sep. PMID 26246218
  4. Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm. Han C, et al. J Cell Physiol, 2011 May. PMID 20945367
  5. Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. Ballock RT, et al. J Cell Physiol, 1994 May. PMID 8163572

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAM7 is required for normal fertility and is important for the maintenance of epididymal integrity and for sperm morphology
    Title: Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7.
  2. Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5, calnexin and Itm2b during capacitation in sperm.
    Title: Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
  3. This study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.
    Title: ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in epididymis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of sperm capacitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 7
Names
a disintegrin and metalloprotease domain (ADAM) 7
epididymal apical protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007402.2 → NP_031428.2  disintegrin and metalloproteinase domain-containing protein 7 preproprotein

    See identical proteins and their annotated locations for NP_031428.2

    Status: REVIEWED

    Source sequence(s)
    AC154706, AF013107, AK136692
    Consensus CDS
    CCDS27234.1
    UniProtKB/Swiss-Prot
    F8VQC6, O35227
    Related
    ENSMUSP00000022640.8, ENSMUST00000022640.8
    Conserved Domains (6) summary
    smart00608
    Location:486 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:199 → 391
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:410 → 482
    Disintegrin; Disintegrin
    pfam01421
    Location:199 → 393
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:63 → 153
    Pep_M12B_propep; Reprolysin family propeptide
    cl14106
    Location:655 → 698
    Rifin_STEVOR; Rifin/stevor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    68734785..68771138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35227.2 GenPept UniProtKB/Swiss-Prot:O35227

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