U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FLYWCH2 FLYWCH family member 2 [ Homo sapiens (human) ]

Gene ID: 114984, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
FLYWCH2provided by HGNC
Official Full Name
FLYWCH family member 2provided by HGNC
Primary source
HGNC:HGNC:25178
See related
Ensembl:ENSG00000162076 AllianceGenome:HGNC:25178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 10.8), prostate (RPKM 8.6) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See FLYWCH2 in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2883195..2899382)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2909827..2926022)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2933196..2949383)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2907556-2908156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908157-2908757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908758-2909357 Neighboring gene serine protease 22 Neighboring gene uncharacterized LOC101929566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2932133-2932633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:2955125-2955625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7084 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:2962376-2962565 Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2974631-2975496 Neighboring gene ribosomal protein L23a pseudogene 86 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:2978151-2978660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2988192-2988805 Neighboring gene uncharacterized LOC105371055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3005307-3006228

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. Zhu X, et al. FASEB J, 2016 Feb. PMID 26472337
  2. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. Scholz CC, et al. PLoS Biol, 2016 Jan. PMID 26752685, Free PMC Article
  3. An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase. Zhou Z, et al. iScience, 2022 Feb 18. PMID 35198878, Free PMC Article
  4. MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Kalkat M, et al. Mol Cell, 2018 Dec 6. PMID 30415952
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale M, et al. Cell, 2014 Jul 17. PMID 25036637, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
FLYWCH family member 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142499.1 → NP_001135971.1  FLYWCH family member 2

    See identical proteins and their annotated locations for NP_001135971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL542248, BC014089, BG120460, CA413438, DB455461
    Consensus CDS
    CCDS10482.1
    UniProtKB/Swiss-Prot
    Q96CP2
    Related
    ENSP00000293981.6, ENST00000293981.10
    Conserved Domains (1) summary
    pfam15423
    Location:1 → 106
    FLYWCH_N; FLYWCH-type zinc finger-containing protein

  2. NM_001142500.1 → NP_001135972.1  FLYWCH family member 2

    See identical proteins and their annotated locations for NP_001135972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC014089, BG120460, BI825861, CA413438, DB455461
    Consensus CDS
    CCDS10482.1
    UniProtKB/Swiss-Prot
    Q96CP2
    Conserved Domains (1) summary
    pfam15423
    Location:1 → 106
    FLYWCH_N; FLYWCH-type zinc finger-containing protein

  3. NM_138439.3 → NP_612448.1  FLYWCH family member 2

    See identical proteins and their annotated locations for NP_612448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    BC014089, BG120460, CA413438, DB455461
    Consensus CDS
    CCDS10482.1
    UniProtKB/Swiss-Prot
    Q96CP2
    Related
    ENSP00000380159.3, ENST00000396958.8
    Conserved Domains (1) summary
    pfam15423
    Location:1 → 106
    FLYWCH_N; FLYWCH-type zinc finger-containing protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2883195..2899382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255078.6 → XP_005255135.1  FLYWCH family member 2 isoform X1

    See identical proteins and their annotated locations for XP_005255135.1

    UniProtKB/Swiss-Prot
    Q96CP2
    Conserved Domains (1) summary
    pfam15423
    Location:1 → 106
    FLYWCH_N; FLYWCH-type zinc finger-containing protein

  2. XM_047433572.1 → XP_047289528.1  FLYWCH family member 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2909827..2926022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379508.1 → XP_054235483.1  FLYWCH family member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q96CP2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96CP2.1 GenPept UniProtKB/Swiss-Prot:Q96CP2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous