Adam4 a disintegrin and metallopeptidase domain 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam4provided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 4provided by MGI
Primary source: MGI:MGI:104731
See related: Ensembl:ENSMUSG00000072972 AllianceGenome:MGI:104731
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: tMDCV
Summary: Predicted to be involved in male gonad development. Located in external side of plasma membrane and sperm head plasma membrane. Is expressed in glossopharyngeal ganglion and trigeminal ganglion. [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12 D1; 12 37.66 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (81466217..81468813, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (81419443..81422039, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The levels of ADAM4 and ADAM6 are dramatically reduced in Adam2 and Adam3 knockout sperm defective in various fertilization processes. We observed premature processing of ADAM4 in the Adam3-null mice.
Title: Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm head plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm head plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: a disintegrin and metallopeptidase domain 4

Names: a disintegrin and metalloprotease domain (ADAM) 4; a disintegrin and metalloprotease domain 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009620.2 → NP_033750.1 a disintegrin and metallopeptidase domain 4 precursor

See identical proteins and their annotated locations for NP_033750.1

Status: VALIDATED

Source sequence(s)

AC132391, AV264697, AV274654, BC150481, BE956537, BF458290

Consensus CDS

CCDS26019.1

UniProtKB/TrEMBL

Q8CGQ2

Related

ENSMUSP00000082427.4, ENSMUST00000085319.4

Conserved Domains (5) summary

smart00050
Location:429 → 503

DISIN; Homologues of snake disintegrins

smart00608
Location:505 → 648

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:213 → 406

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:213 → 405

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:60 → 163

Pep_M12B_propep; Reprolysin family propeptide