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Adam12 ADAM metallopeptidase domain 12 [ Mus musculus (house mouse) ]

Gene ID: 11489, updated on 11-Apr-2024

Summary

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Official Symbol
Adam12provided by MGI
Official Full Name
ADAM metallopeptidase domain 12provided by MGI
Primary source
MGI:MGI:105378
See related
Ensembl:ENSMUSG00000054555 AllianceGenome:MGI:105378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mltna
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein that localizes to the cell surface. About a third of the mice lacking the encoded protein die before weaning. Overexpression of the encoded protein in a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by preventing cell necrosis and inflammation. [provided by RefSeq, May 2016]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 12.7), mammary gland adult (RPKM 6.4) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Adam12 in Genome Data Viewer
Location:
7 F3; 7 77.61 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133484928..133826859, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (133883199..134225097, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20333 Neighboring gene predicted gene 15483 Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene fibronectin type 3 and ankyrin repeat domains 1 Neighboring gene STARR-seq mESC enhancer starr_20336 Neighboring gene STARR-seq mESC enhancer starr_20337 Neighboring gene predicted gene, 51500 Neighboring gene STARR-seq mESC enhancer starr_20338 Neighboring gene predicted gene, 39103 Neighboring gene STARR-seq mESC enhancer starr_20339 Neighboring gene STARR-seq mESC enhancer starr_20340 Neighboring gene STARR-seq mESC enhancer starr_20341 Neighboring gene DNA segment, Chr 7, ERATO Doi 443, expressed Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition. Oh HH, et al. Int J Oncol, 2023 Apr. PMID 36866761, Free PMC Article
  2. ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer. Wang G, et al. Oncoimmunology, 2023. PMID 36545255, Free PMC Article
  3. A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis. Nakamura Y, et al. Am J Physiol Heart Circ Physiol, 2020 Feb 1. PMID 31774689
  4. Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions. Horita M, et al. Calcif Tissue Int, 2019 Jul. PMID 30993375
  5. Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors. Naciri I, et al. Nucleic Acids Res, 2019 Apr 23. PMID 30753595, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy.
    Title: ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy.
  2. A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelialmesenchymal transition.
    Title: A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition.
  3. ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer.
    Title: ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer.
  4. microRNA-29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery.
    Title: microRNA-29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery.
  5. Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth.
    Title: Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth.
  6. Modulation of miR-29a and ADAM12 Reduces Post-Ischemic Skeletal Muscle Injury and Improves Perfusion Recovery and Skeletal Muscle Function in a Mouse Model of Type 2 Diabetes and Peripheral Artery Disease.
    Title: Modulation of miR-29a and ADAM12 Reduces Post-Ischemic Skeletal Muscle Injury and Improves Perfusion Recovery and Skeletal Muscle Function in a Mouse Model of Type 2 Diabetes and Peripheral Artery Disease.
  7. FOXC2/ADAM12-dependent radiosensitivity of head and neck squamous cell carcinoma cells.
    Title: FOXC2/ADAM12-dependent radiosensitivity of head and neck squamous cell carcinoma cells.
  8. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
    Title: Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
  9. Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-beta1-Induced IGF-1 and RUNX-2 Expressions.
    Title: Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions.
  10. ADAM12 regulates cell proliferation of preadipocytes through IGFBP/IGF/mTOR signaling.
    Title: Knockdown of a disintegrin A metalloprotease 12 (ADAM12) during adipogenesis reduces cell numbers, delays differentiation, and increases lipid accumulation in 3T3-L1 cells.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4001

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 12
Names
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
a disintegrin and metalloprotease domain 12
a disintegrin and metalloproteinase domain 12 (meltrin alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007400.3 → NP_031426.2  disintegrin and metalloproteinase domain-containing protein 12 preproprotein

    See identical proteins and their annotated locations for NP_031426.2

    Status: VALIDATED

    Source sequence(s)
    AC125372, AC126676, AC140055
    Consensus CDS
    CCDS21938.1
    UniProtKB/Swiss-Prot
    F8VQN4, Q61824
    Related
    ENSMUSP00000065213.5, ENSMUST00000067680.11
    Conserved Domains (7) summary
    smart00050
    Location:437 → 505
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:508 → 650
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:212 → 412
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam14757
    Location:848 → 896
    NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
    pfam01421
    Location:212 → 414
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:64 → 161
    Pep_M12B_propep; Reprolysin family propeptide
    pfam16885
    Location:751 → 848
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    133484928..133826859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61824.2 GenPept UniProtKB/Swiss-Prot:Q61824

Gene LinkOut

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