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RHPN1 rhophilin Rho GTPase binding protein 1 [ Homo sapiens (human) ]

Gene ID: 114822, updated on 5-Mar-2024

Summary

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Official Symbol
RHPN1provided by HGNC
Official Full Name
rhophilin Rho GTPase binding protein 1provided by HGNC
Primary source
HGNC:HGNC:19973
See related
Ensembl:ENSG00000158106 MIM:601031; AllianceGenome:HGNC:19973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODF5; RHPN; RHOPHILIN
Summary
Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and negative regulation of stress fiber assembly. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 2.9), kidney (RPKM 2.5) and 22 other tissues See more
Orthologs
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Genomic context

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See RHPN1 in Genome Data Viewer
Location:
8q24.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143364255..143384221)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144511888..144531868)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144451046..144466391)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902037 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144389476-144389976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144389977-144390477 Neighboring gene DNA topoisomerase I mitochondrial Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144403237-144403900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144403901-144404564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144404565-144405228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144405229-144405890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144414065-144414598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144416274-144416958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144421307-144422044 Neighboring gene RNA, U6 small nuclear 220, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144450004-144450559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144451300-144452207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144452208-144453114 Neighboring gene RHPN1 antisense RNA 1 (head to head) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144482673-144483320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144483321-144483968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144483969-144484616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144484617-144485263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144487803-144488782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19621 Neighboring gene MAFA antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144504663-144505250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19622 Neighboring gene MAF bZIP transcription factor A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The positive feedback loop of RHPN1-AS1/miR-1299/ETS1 accelerates the deterioration of gastric cancer. Ding L, et al. Biomed Pharmacother, 2020 Apr. PMID 31982726
  2. LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma. Zhang W, et al. Naunyn Schmiedebergs Arch Pharmacol, 2020 Dec. PMID 32435875
  3. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. Peck JW, et al. J Biol Chem, 2002 Nov 15. PMID 12221077
  4. Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production. Popov S, et al. J Virol, 2009 Jul. PMID 19403673, Free PMC Article
  5. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. Fujita A, et al. J Cell Sci, 2000 Jan. PMID 10591629

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma.
    Title: LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma.
  2. The positive feedback loop of RHPN1-AS1/miR-1299/ETS1 accelerates the deterioration of gastric cancer.
    Title: The positive feedback loop of RHPN1-AS1/miR-1299/ETS1 accelerates the deterioration of gastric cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The isolated Bro1 domains of HD-PTP and rhophilin both bind to HIV-1 NC and share the capacity to stimulate VLP production by a minimal HIV-1 Gag molecule PubMed
nucleocapsid gag The isolated Bro1 domains of HD-PTP and rhophilin both bind to HIV-1 NC and share the capacity to stimulate VLP production by a minimal HIV-1 Gag molecule PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA1929

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
rhophilin-1
Names
GTP-Rho-binding protein 1
outer dense fiber of sperm tails 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052924.3 → NP_443156.2  rhophilin-1

    See identical proteins and their annotated locations for NP_443156.2

    Status: VALIDATED

    Source sequence(s)
    AC105118, BC025767, BX341691
    Consensus CDS
    CCDS47927.1
    UniProtKB/Swiss-Prot
    Q8TAV1, Q8TCX5, Q96PV9
    Related
    ENSP00000289013.6, ENST00000289013.11
    Conserved Domains (3) summary
    cd09248
    Location:109 → 493
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:514 → 580
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:21 → 105
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143364255..143384221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421319.1 → XP_047277275.1  rhophilin-1 isoform X6

  2. XM_005250772.4 → XP_005250829.1  rhophilin-1 isoform X1

    See identical proteins and their annotated locations for XP_005250829.1

    Conserved Domains (3) summary
    cd09248
    Location:162 → 546
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:567 → 633
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:74 → 158
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

  3. XM_005250773.4 → XP_005250830.1  rhophilin-1 isoform X2

    Conserved Domains (3) summary
    cd09248
    Location:162 → 545
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    smart00228
    Location:566 → 632
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cl00087
    Location:74 → 158
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

  4. XM_047421316.1 → XP_047277272.1  rhophilin-1 isoform X4

  5. XM_047421320.1 → XP_047277276.1  rhophilin-1 isoform X7

  6. XM_047421322.1 → XP_047277278.1  rhophilin-1 isoform X9

  7. XM_047421321.1 → XP_047277277.1  rhophilin-1 isoform X8

  8. XM_017013015.2 → XP_016868504.1  rhophilin-1 isoform X6

  9. XM_047421315.1 → XP_047277271.1  rhophilin-1 isoform X3

  10. XM_047421318.1 → XP_047277274.1  rhophilin-1 isoform X6

  11. XM_047421317.1 → XP_047277273.1  rhophilin-1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144511888..144531868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359708.1 → XP_054215683.1  rhophilin-1 isoform X6

  2. XM_054359701.1 → XP_054215676.1  rhophilin-1 isoform X1

  3. XM_054359702.1 → XP_054215677.1  rhophilin-1 isoform X2

  4. XM_054359704.1 → XP_054215679.1  rhophilin-1 isoform X4

  5. XM_054359709.1 → XP_054215684.1  rhophilin-1 isoform X7

  6. XM_054359711.1 → XP_054215686.1  rhophilin-1 isoform X9

  7. XM_054359710.1 → XP_054215685.1  rhophilin-1 isoform X8

  8. XM_054359706.1 → XP_054215681.1  rhophilin-1 isoform X6

  9. XM_054359703.1 → XP_054215678.1  rhophilin-1 isoform X3

  10. XM_054359707.1 → XP_054215682.1  rhophilin-1 isoform X6

  11. XM_054359705.1 → XP_054215680.1  rhophilin-1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCX5.2 GenPept UniProtKB/Swiss-Prot:Q8TCX5

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