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Acta2 actin alpha 2, smooth muscle, aorta [ Mus musculus (house mouse) ]

Gene ID: 11475, updated on 11-Apr-2024

Summary

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Official Symbol
Acta2provided by MGI
Official Full Name
actin alpha 2, smooth muscle, aortaprovided by MGI
Primary source
MGI:MGI:87909
See related
Ensembl:ENSMUSG00000035783 AllianceGenome:MGI:87909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Actvs; a-SMA; SMAalpha; SMalphaA; alphaSMA; 0610041G09Rik
Summary
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in smooth muscle. [provided by RefSeq, Feb 2021]
Expression
Biased expression in bladder adult (RPKM 2693.2), ovary adult (RPKM 563.6) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Acta2 in Genome Data Viewer
Location:
19 C1; 19 29.41 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34217736..34232985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34240336..34255585, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene lipase, family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene STARR-seq mESC enhancer starr_45990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:34255778-34255996 Neighboring gene STARR-positive B cell enhancer ABC_E5696 Neighboring gene STAM binding protein like 1 Neighboring gene STARR-seq mESC enhancer starr_45992 Neighboring gene predicted gene, 31355 Neighboring gene STARR-seq mESC enhancer starr_45994 Neighboring gene Fas cell surface death receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Abnormally elevated expression of ACTA2 of circular smooth muscle leads to hyperactive contraction in aganglionic segments of HSCR. Chen K, et al. Pediatr Surg Int, 2023 Jun 6. PMID 37278766, Free PMC Article
  2. Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction. Li Y, et al. J Mol Cell Cardiol, 2022 Oct. PMID 36007455, Free PMC Article
  3. Alpha-Smooth Muscle Actin-Positive Perivascular Cells in Diabetic Retina and Choroid. Kim SJ, et al. Int J Mol Sci, 2020 Mar 20. PMID 32245120, Free PMC Article
  4. Smooth Muscle α-Actin Deficiency Leads to Decreased Liver Fibrosis via Impaired Cytoskeletal Signaling in Hepatic Stellate Cells. Rockey DC, et al. Am J Pathol, 2019 Nov. PMID 31476284, Free PMC Article
  5. Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection. Alarcon-Martinez L, et al. Elife, 2018 Mar 21. PMID 29561727, Free PMC Article

See all (1555) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility.
    Title: Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility.
  2. Abnormally elevated expression of ACTA2 of circular smooth muscle leads to hyperactive contraction in aganglionic segments of HSCR.
    Title: Abnormally elevated expression of ACTA2 of circular smooth muscle leads to hyperactive contraction in aganglionic segments of HSCR.
  3. Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction.
    Title: Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction.
  4. DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition.
    Title: DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition.
  5. Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
    Title: Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells.
  6. Resistance of Acta2(R149C/+) mice to aortic disease is associated with defective release of mutant smooth muscle alpha-actin from the chaperonin-containing TCP1 folding complex.
    Title: Resistance of Acta2(R149C/+) mice to aortic disease is associated with defective release of mutant smooth muscle α-actin from the chaperonin-containing TCP1 folding complex.
  7. The glucagon-like peptide-1 (GLP-1) analog exenatide ameliorates intrauterine adhesions in mice.
    Title: The glucagon-like peptide-1 (GLP-1) analog exenatide ameliorates intrauterine adhesions in mice.
  8. alphaSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression.
    Title: αSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression.
  9. Alpha-Smooth Muscle Actin-Positive Perivascular Cells in Diabetic Retina and Choroid.
    Title: Alpha-Smooth Muscle Actin-Positive Perivascular Cells in Diabetic Retina and Choroid.
  10. There is a relationship between smooth muscle alpha-actin and fibrogenesis in hepatic myofibroblasts in vivo.
    Title: Smooth Muscle α-Actin Deficiency Leads to Decreased Liver Fibrosis via Impaired Cytoskeletal Signaling in Hepatic Stellate Cells.
Submit: New GeneRIF Correction See all GeneRIFs (62)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hepatic stellate cell contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hepatic stellate cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in smooth muscle contractile fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin, aortic smooth muscle
Names
actin, alpha, vascular smooth muscle
alpha-actin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007392.3 → NP_031418.1  actin, aortic smooth muscle

    See identical proteins and their annotated locations for NP_031418.1

    Status: REVIEWED

    Source sequence(s)
    AC102285, AK017374
    Consensus CDS
    CCDS29757.1
    UniProtKB/Swiss-Prot
    P62737
    UniProtKB/TrEMBL
    Q3U122
    Related
    ENSMUSP00000048218.9, ENSMUST00000039631.10
    Conserved Domains (1) summary
    PTZ00281
    Location:3 → 377
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34217736..34232985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526606.2 → XP_006526669.1  actin, aortic smooth muscle isoform X1

    UniProtKB/TrEMBL
    E9Q5F4
    Conserved Domains (1) summary
    cl17037
    Location:3 → 280
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62737.1 GenPept UniProtKB/Swiss-Prot:P62737

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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