Spred1 sprouty protein with EVH-1 domain 1, related sequence [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spred1provided by MGI
Official Full Name: sprouty protein with EVH-1 domain 1, related sequenceprovided by MGI
Primary source: MGI:MGI:2150016
See related: Ensembl:ENSMUSG00000027351 AllianceGenome:MGI:2150016
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730461F13Rik
Summary: This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression: Ubiquitous expression in adrenal adult (RPKM 12.0), cortex adult (RPKM 10.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.03 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (116951576..117012760)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (117121071..117182279)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spred1 deficit promotes treatment resistance and transformation of chronic phase CML.
Title: Spred1 deficit promotes treatment resistance and transformation of chronic phase CML.
Impaired instrumental learning in Spred1(-/-) mice, a model for a rare RASopathy.
Title: Impaired instrumental learning in Spred1(-/-) mice, a model for a rare RASopathy.
Using established mice lines deficient for either or both Spred 1 and Spred 2, we demonstrate their role in regulating lens development by negatively regulating ERK1/2 activity.
Title: The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis.
Exercise training increased endothelial progenitor cells function in experimental myocardial infarction mice and miR-126 expression, while Spred1 expression was significantly down-regulated.
Title: TPPU enhanced exercise-induced epoxyeicosatrienoic acid concentrations to exert cardioprotection in mice after myocardial infarction.
The Spred1 deficiency mitigates hematopoietic stem cell (HSC) failure induced by infection mimetics and prolongs HSC lifespan, but it does not initiate leukemogenesis due to compensatory upregulation of Spred2.
Title: Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
Title: Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer: a working hypothesis.
SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK signaling pathway in pluripotent cells
Title: SPREDs (Sprouty related proteins with EVH1 domain) promote self-renewal and inhibit mesodermal differentiation in murine embryonic stem cells.
The data suggest that Spred1 negatively regulates group 2 innate lymphoid cell development and functions through the suppression of the Ras-ERK pathway.
Title: Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells.
Microrna-126 was transported into recipient human coronary artery endothelial cells by endothelial microparticles and functionally regulated the target protein sprouty-related, EVH1 domain-containing protein 1 (SPRED1).
Title: Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles.
show that neurofibromin, the NF1 gene product, is a Spred1-interacting protein that is necessary for Spred1's inhibitory function
Title: A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Rat86 (e-PCR)
- UniSTS:118795

MT4461 (e-PCR)
- UniSTS:129294

D2Mit394.2 (e-PCR), detects polymorphism
- UniSTS:129295

RH125528 (e-PCR)
- UniSTS:162344

Spred1 (e-PCR), detects polymorphism
- UniSTS:528299

AW047647 (e-PCR)
- UniSTS:178677

Spred1 (e-PCR), detects polymorphism
- UniSTS:547837

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables stem cell factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lens fiber cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vasculogenesis involved in coronary vascular morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sprouty-related, EVH1 domain-containing protein 1

Names: sprouty-related protein 1 with EVH-1 domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277256.2 → NP_001264185.1 sprouty-related, EVH1 domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL807741, AL928959

Consensus CDS

CCDS71115.1

UniProtKB/Swiss-Prot

Q924S8

Related

ENSMUSP00000106526.2, ENSMUST00000110901.2

Conserved Domains (1) summary

cd10574
Location:13 → 125

EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
NM_033524.4 → NP_277059.1 sprouty-related, EVH1 domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_277059.1

Status: VALIDATED

Source sequence(s)

AL807741, AL928959

Consensus CDS

CCDS16570.1

UniProtKB/Swiss-Prot

Q3U2W6, Q6PET8, Q924S8

Related

ENSMUSP00000028829.7, ENSMUST00000028829.13

Conserved Domains (2) summary

cd10574
Location:13 → 125

EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

pfam05210
Location:333 → 428

Sprouty; Sprouty protein (Spry)