Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsd17b11provided by MGI
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 11provided by MGI
Primary source: MGI:MGI:2149821
See related: Ensembl:ENSMUSG00000029311 AllianceGenome:MGI:2149821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SDR2; Dhrs8; Pan1b; retSDR2
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Predicted to be involved in androgen catabolic process. Predicted to act upstream of or within steroid biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and sensory organ. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 49.0), duodenum adult (RPKM 48.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 50.52 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (104137631..104169662, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (103989765..104021796, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data indicate that 17beta-HSD11 localizes both in the endoplasmic reticulum and in lipid droplets, depending on physiologic conditions
Title: Regulated expression by PPARalpha and unique localization of 17beta-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit275 (e-PCR), detects polymorphism
- UniSTS:130414

BE136611 (e-PCR)
- UniSTS:207834

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables steroid dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in androgen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: estradiol 17-beta-dehydrogenase 11

Names: 17-beta-HSD 11; 17-beta-HSD XI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; 17bHSD11; 17beta-HSD11; 17betaHSD11; 17betaHSDXI; dehydrogenase/reductase (SDR family) member 8; retinal short-chain dehydrogenase/reductase 2; retinal short-chain dehydrogenase/reductase SDR2

NP_444492.1

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053262.3 → NP_444492.1 estradiol 17-beta-dehydrogenase 11 precursor

See identical proteins and their annotated locations for NP_444492.1

Status: PROVISIONAL

Source sequence(s)

AL714024

Consensus CDS

CCDS19481.1

UniProtKB/Swiss-Prot

Q3U2P6, Q8BR33, Q8C7S0, Q9EQ06

Related

ENSMUSP00000031251.10, ENSMUST00000031251.16

Conserved Domains (2) summary

cd05339
Location:38 → 277

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

pfam00106
Location:37 → 228

adh_short; short chain dehydrogenase