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Elac1 elaC ribonuclease Z 1 [ Mus musculus (house mouse) ]

Gene ID: 114615, updated on 11-Apr-2024

Summary

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Official Symbol
Elac1provided by MGI
Official Full Name
elaC ribonuclease Z 1provided by MGI
Primary source
MGI:MGI:1890495
See related
Ensembl:ENSMUSG00000036941 AllianceGenome:MGI:1890495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610018O07Rik; 8430417G19Rik
Summary
Predicted to enable 3'-tRNA processing endoribonuclease activity. Predicted to be involved in tRNA 3'-trailer cleavage. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ELAC1 (elaC ribonuclease Z 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 4.6), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Elac1 in Genome Data Viewer
Location:
18 E2; 18 49.83 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73868109..73887589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73735038..73754519, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44993 Neighboring gene predicted gene, 32548 Neighboring gene EGF-like domain 7 pseudogene Neighboring gene malic enzyme 2, NAD(+)-dependent, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E11003 Neighboring gene predicted gene, 52346

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A candidate prostate cancer susceptibility gene at chromosome 17p. Tavtigian SV, et al. Nat Genet, 2001 Feb. PMID 11175785
  2. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Wang B, et al. Development, 2011 Oct. PMID 21937600, Free PMC Article
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-tRNA processing endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity, producing 5'-phosphomonoesters IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc phosphodiesterase ELAC protein 1
Names
RNase Z 1
elaC homolog 1
elaC homolog protein 1
ribonuclease Z 1
tRNA 3 endonuclease 1
tRNase Z 1
NP_444485.2
XP_030106136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053255.3 → NP_444485.2  zinc phosphodiesterase ELAC protein 1

    See identical proteins and their annotated locations for NP_444485.2

    Status: VALIDATED

    Source sequence(s)
    AC132418, AF308697, AK018424, BY286576, CV556353
    Consensus CDS
    CCDS37855.1
    UniProtKB/Swiss-Prot
    Q8VEB6, Q9CXB1, Q9ERF4
    Related
    ENSMUSP00000041793.3, ENSMUST00000041138.3
    Conserved Domains (2) summary
    COG1234
    Location:3 → 359
    ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
    TIGR02651
    Location:4 → 358
    RNase_Z; ribonuclease Z

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    73868109..73887589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250276.2 → XP_030106136.1  zinc phosphodiesterase ELAC protein 1 isoform X1

    Conserved Domains (1) summary
    cd07717
    Location:5 → 195
    RNaseZ_ZiPD-like_MBL-fold; Ribonuclease Z, E. coli 3' tRNA-processing endonuclease ZiPD and related proteins; MBL-fold metallo-hydrolase domain

RNA

  1. XR_385970.5 RNA Sequence

  2. XR_003952490.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEB6.1 GenPept UniProtKB/Swiss-Prot:Q8VEB6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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