Tle6 transducin-like enhancer of split 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tle6provided by MGI
Official Full Name: transducin-like enhancer of split 6provided by MGI
Primary source: MGI:MGI:2149593
See related: Ensembl:ENSMUSG00000034758 AllianceGenome:MGI:2149593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Grg6; 1810057E06Rik
Summary: Predicted to enable transcription corepressor activity. Involved in several processes, including cytoskeleton organization; positive regulation of embryonic development; and spermatogonial cell division. Acts upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Located in cell cortex and nucleus. Part of subcortical maternal complex. Is expressed in several structures, including brain; early conceptus; foregut-midgut junction; gonad; and metanephric mesenchyme. Human ortholog(s) of this gene implicated in infertility. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 24.8), adrenal adult (RPKM 10.1) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81426738..81437021, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81590904..81601185, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of the Transducin-Like Enhancer of Split 6 Gene Affects the Proliferation and Cell Cycle Process of Mouse Spermatogonia.
Title: Knockout of the Transducin-Like Enhancer of Split 6 Gene Affects the Proliferation and Cell Cycle Process of Mouse Spermatogonia.
TLE6 stabilizes the subcortical maternal complex (SCMC). SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division.
Title: The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.
TLE6 localized to the oocyte cortex throughout meiosis in a manner that is spatially and temporally consistent with the localization of critical protein kinase A subunits
Title: Transducin-like enhancer of split-6 (TLE6) is a substrate of protein kinase A activity during mouse oocyte maturation.
Results describe a subcortical maternal complex, containing Mater, Floped, TLE6, and Filia, that is essential for preimplantation mouse embryogenesis.
Title: A subcortical maternal complex essential for preimplantation mouse embryogenesis.
Expression of Tle6-like in colon cancer cells increased cell proliferation, colony-formation, cell migration, and xenograft tumorgenicity.
Title: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
Grg6 is expressed in cortical neural progenitor cells, interacts with BF-1, and plays a role in in cortical neuron development.
Title: Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tle6 (e-PCR), detects polymorphism
- UniSTS:525518

Tle6 (e-PCR), detects polymorphism
- UniSTS:525280

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogonial cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of subcortical maternal complex	IDA Inferred from Direct Assay more info	PubMed
part_of subcortical maternal complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 6

Names: Groucho-related protein 6; transducin-like enhancer of split 6, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346695.1 → NP_001333624.1 transducin-like enhancer protein 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC153919

Consensus CDS

CCDS83737.1

UniProtKB/TrEMBL

D3Z5E1

Related

ENSMUSP00000117287.2, ENSMUST00000142948.8

Conserved Domains (2) summary

sd00039
Location:289 → 331

7WD40; WD40 repeat [structural motif]

cl29593
Location:277 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001359134.1 → NP_001346063.1 transducin-like enhancer protein 6 isoform 3

Status: VALIDATED

Source sequence(s)

BC048832

UniProtKB/TrEMBL

Q80XH3

Related

ENSMUST00000128278.8

Conserved Domains (2) summary

sd00039
Location:226 → 268

7WD40; WD40 repeat [structural motif]

cl29593
Location:214 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001359135.1 → NP_001346064.1 transducin-like enhancer protein 6 isoform 3

Status: VALIDATED

Source sequence(s)

BC048832, BY236020

UniProtKB/TrEMBL

Q80XH3

Conserved Domains (2) summary

sd00039
Location:226 → 268

7WD40; WD40 repeat [structural motif]

cl29593
Location:214 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_053254.2 → NP_444484.1 transducin-like enhancer protein 6 isoform 1

See identical proteins and their annotated locations for NP_444484.1

Status: VALIDATED

Source sequence(s)

AC153919

Consensus CDS

CCDS24064.1

UniProtKB/Swiss-Prot

Q9WVB3

Related

ENSMUSP00000071905.3, ENSMUST00000072020.9

Conserved Domains (2) summary

sd00039
Location:299 → 341

7WD40; WD40 repeat [structural motif]

cl29593
Location:287 → 573

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

81426738..81437021 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513083.4 → XP_006513146.1 transducin-like enhancer protein 6 isoform X1

See identical proteins and their annotated locations for XP_006513146.1

Conserved Domains (2) summary

sd00039
Location:299 → 369

7WD40; WD40 repeat [structural motif]

cl29593
Location:287 → 601

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155507.1 → XP_036011400.1 transducin-like enhancer protein 6 isoform X4

UniProtKB/TrEMBL

D3Z5E1

Conserved Domains (2) summary

sd00039
Location:289 → 331

7WD40; WD40 repeat [structural motif]

cl29593
Location:277 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155506.1 → XP_036011399.1 transducin-like enhancer protein 6 isoform X3

UniProtKB/Swiss-Prot

Q9WVB3

Conserved Domains (2) summary

sd00039
Location:299 → 341

7WD40; WD40 repeat [structural motif]

cl29593
Location:287 → 573

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006513085.5 → XP_006513148.1 transducin-like enhancer protein 6 isoform X2

Conserved Domains (2) summary

sd00039
Location:289 → 359

7WD40; WD40 repeat [structural motif]

cl29593
Location:277 → 591

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006513081.5 → XP_006513144.1 transducin-like enhancer protein 6 isoform X1

See identical proteins and their annotated locations for XP_006513144.1

Conserved Domains (2) summary

sd00039
Location:299 → 369

7WD40; WD40 repeat [structural motif]

cl29593
Location:287 → 601

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017313766.3 → XP_017169255.1 transducin-like enhancer protein 6 isoform X5

Conserved Domains (2) summary

COG2319
Location:198 → 560

WD40; WD40 repeat [General function prediction only]

sd00039
Location:259 → 329

7WD40; WD40 repeat [structural motif]
XM_036155512.1 → XP_036011405.1 transducin-like enhancer protein 6 isoform X8

Conserved Domains (2) summary

sd00039
Location:216 → 258

7WD40; WD40 repeat [structural motif]

cl29593
Location:204 → 490

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155511.1 → XP_036011404.1 transducin-like enhancer protein 6 isoform X9

UniProtKB/TrEMBL

Q80XH3

Conserved Domains (2) summary

sd00039
Location:226 → 268

7WD40; WD40 repeat [structural motif]

cl29593
Location:214 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155513.1 → XP_036011406.1 transducin-like enhancer protein 6 isoform X8

Conserved Domains (2) summary

sd00039
Location:216 → 258

7WD40; WD40 repeat [structural motif]

cl29593
Location:204 → 490

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155508.1 → XP_036011401.1 transducin-like enhancer protein 6 isoform X6

Conserved Domains (2) summary

COG2319
Location:165 → 527

WD40; WD40 repeat [General function prediction only]

sd00039
Location:226 → 296

7WD40; WD40 repeat [structural motif]
XM_036155509.1 → XP_036011402.1 transducin-like enhancer protein 6 isoform X7

Conserved Domains (2) summary

COG2319
Location:155 → 517

WD40; WD40 repeat [General function prediction only]

sd00039
Location:216 → 286

7WD40; WD40 repeat [structural motif]
XM_006513088.4 → XP_006513151.1 transducin-like enhancer protein 6 isoform X6

See identical proteins and their annotated locations for XP_006513151.1

Conserved Domains (2) summary

COG2319
Location:165 → 527

WD40; WD40 repeat [General function prediction only]

sd00039
Location:226 → 296

7WD40; WD40 repeat [structural motif]
XM_030244827.2 → XP_030100687.1 transducin-like enhancer protein 6 isoform X6

Conserved Domains (2) summary

COG2319
Location:165 → 527

WD40; WD40 repeat [General function prediction only]

sd00039
Location:226 → 296

7WD40; WD40 repeat [structural motif]
XM_030244828.2 → XP_030100688.1 transducin-like enhancer protein 6 isoform X7

Conserved Domains (2) summary

COG2319
Location:155 → 517

WD40; WD40 repeat [General function prediction only]

sd00039
Location:216 → 286

7WD40; WD40 repeat [structural motif]
XM_036155510.1 → XP_036011403.1 transducin-like enhancer protein 6 isoform X8

Related

ENSMUST00000137631.8

Conserved Domains (2) summary

sd00039
Location:216 → 258

7WD40; WD40 repeat [structural motif]

cl29593
Location:204 → 490

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...