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Zmynd10 zinc finger, MYND domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 114602, updated on 21-Apr-2024

Summary

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Official Symbol
Zmynd10provided by MGI
Official Full Name
zinc finger, MYND domain containing 10provided by MGI
Primary source
MGI:MGI:2387863
See related
Ensembl:ENSMUSG00000010044 AllianceGenome:MGI:2387863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Blu
Summary
Enables molecular adaptor activity and protein folding chaperone. Involved in outer dynein arm assembly and positive regulation of motile cilium assembly. Acts upstream of or within several processes, including cilium assembly; cilium movement; and protein localization to cilium. Located in apical plasma membrane and cytoplasm. Is expressed in bronchiole epithelium; lung; lung epithelium; nasal cavity epithelium; and nasal cavity respiratory epithelium. Used to study primary ciliary dyskinesia 22. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 22. Orthologous to human ZMYND10 (zinc finger MYND-type containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 56.3) and kidney adult (RPKM 6.2) See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 58.12 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107424067..107428520)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107546872..107551321)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cytochrome b-561 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene Ras association (RalGDS/AF-6) domain family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers. Agathanggelou A, et al. Oncogene, 2003 Mar 13. PMID 12629521
  2. Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. Moore DJ, et al. Am J Hum Genet, 2013 Aug 8. PMID 23891471, Free PMC Article
  3. ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. Cho KJ, et al. PLoS Genet, 2018 Mar. PMID 29601588, Free PMC Article
  4. ZMYND10 functions in a chaperone relay during axonemal dynein assembly. Mali GR, et al. Elife, 2018 Jun 19. PMID 29916806, Free PMC Article
  5. MORC2B is essential for meiotic progression and fertility. Shi B, et al. PLoS Genet, 2018 Jan. PMID 29329290, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cilium movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inner dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inner dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within outer dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in outer dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger MYND domain-containing protein 10
Names
protein BLu

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379079.1 → NP_001366008.1  zinc finger MYND domain-containing protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform 3.
    Source sequence(s)
    AL672219
    Conserved Domains (1) summary
    pfam01753
    Location:351 → 387
    zf-MYND; MYND finger

  2. NM_001379080.1 → NP_001366009.1  zinc finger MYND domain-containing protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AL672219
    Conserved Domains (1) summary
    pfam01753
    Location:351 → 387
    zf-MYND; MYND finger

  3. NM_001404947.1 → NP_001391876.1  zinc finger MYND domain-containing protein 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672219

  4. NM_053253.4 → NP_444483.2  zinc finger MYND domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_444483.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL672219, BC052357, BY284492
    Consensus CDS
    CCDS23493.1
    UniProtKB/Swiss-Prot
    Q3V1P0, Q80W73, Q99ML0
    Related
    ENSMUSP00000010188.8, ENSMUST00000010188.9
    Conserved Domains (1) summary
    pfam01753
    Location:394 → 430
    zf-MYND; MYND finger

RNA

  1. NR_166465.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672219
    Related
    ENSMUST00000193303.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107424067..107428520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511630.4 → XP_006511693.1  zinc finger MYND domain-containing protein 10 isoform X1

    Conserved Domains (1) summary
    pfam01753
    Location:432 → 468
    zf-MYND; MYND finger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99ML0.2 GenPept UniProtKB/Swiss-Prot:Q99ML0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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