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Ehbp1l1 EH domain binding protein 1-like 1 [ Mus musculus (house mouse) ]

Gene ID: 114601, updated on 21-Apr-2024

Summary

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Official Symbol
Ehbp1l1provided by MGI
Official Full Name
EH domain binding protein 1-like 1provided by MGI
Primary source
MGI:MGI:3612340
See related
Ensembl:ENSMUSG00000024937 AllianceGenome:MGI:3612340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G430002G23Rik
Summary
Predicted to be involved in actin cytoskeleton organization. Predicted to be located in endosome. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in bladder; gut; liver lobe; musculature; and tail mesenchyme. Orthologous to human EHBP1L1 (EH domain binding protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 26.4), liver E14 (RPKM 25.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.34 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5757397..5776504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5707369..5726576, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene STARR-positive B cell enhancer ABC_E4259 Neighboring gene STARR-positive B cell enhancer ABC_E11012 Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene potassium channel, subfamily K, member 7 Neighboring gene family with sequence similarity 89, member B Neighboring gene zinc ribbon domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of genes downstream of Pax6 in the mouse lens using cDNA microarrays. Chauhan BK, et al. J Biol Chem, 2002 Mar 29. PMID 11790784
  2. The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. Sobajima T, et al. J Cell Biol, 2018 May 7. PMID 29514919, Free PMC Article
  3. Genetic predisposition to tinnitus in the UK Biobank population. Urbanek ME, et al. Sci Rep, 2021 Sep 13. PMID 34518561, Free PMC Article
  4. EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. Nakajo A, et al. J Cell Biol, 2016 Feb 1. PMID 26833786, Free PMC Article
  5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.
    Title: EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.
  2. Data demonstrate that EHBP1L1 links Rab8 and the Bin1-dynamin complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.
    Title: EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EH domain-binding protein 1-like protein 1
Names
tangerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114595.1 → NP_001108067.1  EH domain-binding protein 1-like protein 1 isoform C

    See identical proteins and their annotated locations for NP_001108067.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS89317.1
    UniProtKB/TrEMBL
    A0A494B9G7
    Related
    ENSMUSP00000157612.2, ENSMUST00000235730.2
    Conserved Domains (3) summary
    pfam00307
    Location:255 → 354
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:598 → 738
    DUF3585; Protein of unknown function (DUF3585)

  2. NM_001114596.1 → NP_001108068.1  EH domain-binding protein 1-like protein 1 isoform D

    See identical proteins and their annotated locations for NP_001108068.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS50360.1
    UniProtKB/TrEMBL
    G5E8Y6
    Related
    ENSMUSP00000126740.2, ENSMUST00000075606.6
    Conserved Domains (3) summary
    pfam00307
    Location:267 → 366
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:610 → 750
    DUF3585; Protein of unknown function (DUF3585)

  3. NM_001114597.1 → NP_001108069.1  EH domain-binding protein 1-like protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS50359.1
    UniProtKB/Swiss-Prot
    Q3V443, Q8C2W6, Q99J97, Q99MS5, Q99MS6, Q99MS7
    UniProtKB/TrEMBL
    E9QP49
    Related
    ENSMUSP00000037656.9, ENSMUST00000049295.15
    Conserved Domains (4) summary
    pfam09528
    Location:583 → 1163
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    pfam00307
    Location:1211 → 1310
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1554 → 1694
    DUF3585; Protein of unknown function (DUF3585)

  4. NM_001381901.1 → NP_001368830.1  EH domain-binding protein 1-like protein 1 isoform E

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Conserved Domains (4) summary
    PRK07764
    Location:292 → 501
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:854 → 985
    DUF3585; Protein of unknown function (DUF3585)
    cd21255
    Location:507 → 611
    CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

  5. NM_053252.3 → NP_444482.2  EH domain-binding protein 1-like protein 1 isoform B

    See identical proteins and their annotated locations for NP_444482.2

    Status: VALIDATED

    Source sequence(s)
    AC134563, AK087817, AK089917, BY749669
    Consensus CDS
    CCDS89316.1
    UniProtKB/TrEMBL
    A0A494BA91
    Related
    ENSMUSP00000157990.2, ENSMUST00000236215.2
    Conserved Domains (3) summary
    pfam00307
    Location:370 → 469
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:713 → 853
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5757397..5776504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250701.2 → XP_030106561.1  EH domain-binding protein 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3V443, Q8C2W6, Q99J97, Q99MS5, Q99MS6, Q99MS7
    Conserved Domains (4) summary
    PHA03307
    Location:185 → 538
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00307
    Location:1223 → 1322
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1570 → 1706
    DUF3585; Protein of unknown function (DUF3585)

  2. XM_030250703.2 → XP_030106563.1  EH domain-binding protein 1-like protein 1 isoform X2

    Conserved Domains (4) summary
    PRK07764
    Location:304 → 513
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam00307
    Location:519 → 618
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:866 → 1002
    DUF3585; Protein of unknown function (DUF3585)

  3. XM_030250705.2 → XP_030106565.1  EH domain-binding protein 1-like protein 1 isoform X3

    Conserved Domains (4) summary
    PRK12678
    Location:269 → 445
    PRK12678; transcription termination factor Rho; Provisional
    pfam00307
    Location:461 → 560
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:808 → 944
    DUF3585; Protein of unknown function (DUF3585)

  4. XM_006531634.4 → XP_006531697.1  EH domain-binding protein 1-like protein 1 isoform X4

    Conserved Domains (4) summary
    PRK12678
    Location:257 → 433
    PRK12678; transcription termination factor Rho; Provisional
    pfam00307
    Location:449 → 548
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:796 → 932
    DUF3585; Protein of unknown function (DUF3585)

  5. XM_006531635.4 → XP_006531698.1  EH domain-binding protein 1-like protein 1 isoform X5

    Conserved Domains (3) summary
    pfam00307
    Location:382 → 481
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 164
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:729 → 865
    DUF3585; Protein of unknown function (DUF3585)

  6. XM_030250707.2 → XP_030106567.1  EH domain-binding protein 1-like protein 1 isoform X7

    Conserved Domains (2) summary
    pfam12130
    Location:364 → 495
    DUF3585; Protein of unknown function (DUF3585)
    cd21255
    Location:17 → 121
    CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

  7. XM_036161403.1 → XP_036017296.1  EH domain-binding protein 1-like protein 1 isoform X7

    Conserved Domains (2) summary
    pfam12130
    Location:364 → 495
    DUF3585; Protein of unknown function (DUF3585)
    cd21255
    Location:17 → 121
    CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

  8. XM_036161402.1 → XP_036017295.1  EH domain-binding protein 1-like protein 1 isoform X6

    Conserved Domains (2) summary
    pfam12130
    Location:454 → 585
    DUF3585; Protein of unknown function (DUF3585)
    cd21255
    Location:107 → 211
    CH_EHBP1L1; calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins

RNA

  1. XR_003952738.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MS7.1 GenPept UniProtKB/Swiss-Prot:Q99MS7

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