Acrv1 acrosomal vesicle protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acrv1provided by MGI
Official Full Name: acrosomal vesicle protein 1provided by MGI
Primary source: MGI:MGI:104590
See related: Ensembl:ENSMUSG00000032110 AllianceGenome:MGI:104590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Msa63; SP-10
Summary: Located in acrosomal vesicle. Is expressed in epididymis; mammary gland; skeletal muscle; stomach fundus; and testis. Orthologous to human ACRV1 (acrosomal vesicle protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 178.7) See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.67 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (36604550..36610139)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (36693220..36698845)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptional regulation of spatiotemporal gene expression within the seminiferous epithelium: Mouse Acrv1 gene as a model.
Title: Transcriptional regulation of spatiotemporal gene expression within the seminiferous epithelium: Mouse Acrv1 gene as a model.
A 50-bp enhancer of the mouse acrosomal vesicle protein 1 gene activates round spermatid-specific transcription in vivodagger.
Title: A 50-bp enhancer of the mouse acrosomal vesicle protein 1 gene activates round spermatid-specific transcription in vivo†.
Loss of ACRV1 led to the progression of pancreatic intraductal carcinoma in mouse models.
Title: Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS.
Using RT-PCR analysis of mouse ACRV1, we determined that ACRV1 was expressed specifically in the testis, and its expression began at days 35.
Title: Developmental expression of ACRV1 in humans and mice.
TDP-43 is a transcriptional repressor and that it regulates spatiotemporal expression of the acrv1 gene during spermatogenesis.
Title: TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.
we propose that NF45 and NF90 have the potential to activate SP-10 gene transcription, and that a chromatin modification event must occur first in order to provide access to these transcription factors.
Title: NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription.
A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function.
Title: A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

mAcrv1 (e-PCR)
- UniSTS:514569

U31992 (e-PCR)
- UniSTS:125720

U31992 (e-PCR)
- UniSTS:163455

Acrv1 (e-PCR), detects polymorphism
- UniSTS:141012

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acrosomal protein SP-10

Names: MSA-63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409573.1 → NP_001396502.1 acrosomal protein SP-10 isoform 2

Status: VALIDATED

Source sequence(s)

AC155921
NM_007391.4 → NP_031417.2 acrosomal protein SP-10 isoform 1 precursor

See identical proteins and their annotated locations for NP_031417.2

Status: VALIDATED

Source sequence(s)

AC155921

Consensus CDS

CCDS22971.1

UniProtKB/Swiss-Prot

B2RT20, P50289, Q9DAM6

Related

ENSMUSP00000034620.4, ENSMUST00000034620.5

Conserved Domains (1) summary

cd00117
Location:185 → 260

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...