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Wnt2 Wnt family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114487, updated on 13-Apr-2024

Summary

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Official Symbol
Wnt2provided by RGD
Official Full Name
Wnt family member 2provided by RGD
Primary source
RGD:621346
See related
Ensembl:ENSRNOG00000051905 AllianceGenome:RGD:621346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wnt
Summary
Predicted to enable cytokine activity and frizzled binding activity. Involved in lung development and positive regulation of endothelial cell proliferation. Located in cytoplasm. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 59.5), Lung (RPKM 52.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wnt2 in Genome Data Viewer
Location:
4q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (47294300..47340284, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (46328408..46374673, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (45286845..45332899, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 7 Neighboring gene 60S ribosomal protein L23a-like Neighboring gene uncharacterized LOC134486733 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene CF transmembrane conductance regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2. Wayman GA, et al. Neuron, 2006 Jun 15. PMID 16772171
  2. Expression of twist and wnt in human breast cancer. Watanabe O, et al. Anticancer Res, 2004 Nov-Dec. PMID 15736421
  3. Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis. Madsen TM, et al. Biol Psychiatry, 2003 Nov 15. PMID 14625142
  4. Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification. Habuchi T, et al. J Natl Cancer Inst, 1994 Sep 7. PMID 8064891
  5. Analysis of genetic alterations related to the development and progression of breast carcinoma. Nagayama K, et al. Jpn J Cancer Res, 1993 Nov. PMID 7903963, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/beta-catenin signaling in methotrexate-induced rat ileal mucositis.
    Title: Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis.
  2. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats.
    Title: Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats.
  3. Collectively, these data reveal that low-affinity nerve growth factor receptor (LNGFR) targets the Wnt/beta-catenin pathway and positively regulates ectomesenchymal stem cells osteogenic differentiation, suggesting that Wnt/beta-catenin pathway may be involved in the development of teeth.
    Title: LNGFR targets the Wnt/β-catenin pathway and promotes the osteogenic differentiation in rat ectomesenchymal stem cells.
  4. Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling.
    Title: Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling.
  5. In conclusion, naringin could prevent progress of disuse osteoporosis in rats, which may be mediated by increased periostin expression and subsequently inhibition of sclerostin and activation of Wnt/beta-catenin signaling pathways.
    Title: Involvement of periostin-sclerostin-Wnt/β-catenin signaling pathway in the prevention of neurectomy-induced bone loss by naringin.
  6. When the Wnt/beta-catenin pathway was activated by LiCl, the expression of RANKL was significantly increased.
    Title: Implication of receptor activator of NF-κB ligand in Wnt/β-catenin pathway promoting osteoblast-like cell differentiation.
  7. Wnt/beta-catenin signaling could induce mesenchymal stem cells aging through promoting the intracellular production of ROS, and ROS may be the main mediators of MSC aging induced by excessive activation of Wnt/beta-catenin signaling.
    Title: Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production.
  8. Wnt2 overexpression in DC3 granulosa cells promotes cytosolic and nuclear accumulation of beta-catenin (CTNNB1), but does not stimulate CTNNB1/TCF-dependent (pGL3-OT) transcriptional activity
    Title: Characterization of Wnt2 overexpression in a rat granulosa cell line (DC3): effects on CTNNB1 activation.
  9. The activation of Wnt/beta-catenin signaling transduction pathway might be one of the reasons for rat hepatocarcinogenesis.
    Title: [Role of Wnt/beta-catenin signaling transduction pathway in rat hepatocarcinogenesis].
  10. Wnt2 is an autocrine growth and differentiation factor specific for hepatic sinusoidal endothelial cells that synergizes with the VEGF signaling pathway to exert its effects.
    Title: Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within atrial cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell proliferation in midbrain ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
Inferred from Sequence Orthology
more info
  
involved_in lung development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within lung induction ISO
Inferred from Sequence Orthology
more info
  
involved_in mammary gland epithelium development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in midbrain dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein Wnt-2
Names
wingless-related MMTV integration site 2
wingless-type MMTV integration site 2
wingless-type MMTV integration site family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053695.1 → NP_446147.1  protein Wnt-2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JZF4, A6IE38, Q2IBD1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    47294300..47340284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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