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Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 [ Mus musculus (house mouse) ]

Gene ID: 114479, updated on 11-Apr-2024

Summary

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Official Symbol
Slc5a5provided by MGI
Official Full Name
solute carrier family 5 (sodium iodide symporter), member 5provided by MGI
Primary source
MGI:MGI:2149330
See related
Ensembl:ENSMUSG00000000792 AllianceGenome:MGI:2149330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NIS
Summary
Enables sodium:iodide symporter activity. Predicted to be involved in iodide transmembrane transport and sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in nucleus. Predicted to be active in plasma membrane. Is expressed in axial skeleton tail region; stomach; testis; and thyroid gland. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 130.4) and mammary gland adult (RPKM 64.6) See more
Orthologs
human all
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Genomic context

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See Slc5a5 in Genome Data Viewer
Location:
8 B3.3; 8 34.36 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71335529..71345429, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70882885..70892785, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73389712-73389895 Neighboring gene coiled-coil domain containing 124 Neighboring gene STARR-positive B cell enhancer ABC_E8242 Neighboring gene STARR-seq mESC enhancer starr_21801 Neighboring gene ribosomal protein L18A Neighboring gene microRNA 7067 Neighboring gene small nucleolar RNA, H/ACA box 68

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene. Hickey RD, et al. Liver Transpl, 2015 Apr. PMID 25482651, Free PMC Article
  2. Targeted radioiodine therapy of neuroblastoma tumors following systemic nonviral delivery of the sodium iodide symporter gene. Klutz K, et al. Clin Cancer Res, 2009 Oct 1. PMID 19789324
  3. Cloning of the mouse sodium iodide symporter. Pinke LA, et al. Thyroid, 2001 Oct. PMID 11716040
  4. The paradoxical lean phenotype of hypothyroid mice is marked by increased adaptive thermogenesis in the skeletal muscle. Kaspari RR, et al. Proc Natl Acad Sci U S A, 2020 Sep 8. PMID 32826330, Free PMC Article
  5. Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Ferrandino G, et al. Proc Natl Acad Sci U S A, 2017 Oct 24. PMID 29073114, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using Slc5a5 transgenic mice.
    Title: Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene.
  2. High potential of novel pseudodendritic polymers for tumor-specific NIS gene delivery after systemic application, opening the prospect of targeted NIS-mediated radionuclide therapy of nonthyroidal tumors even in metastatic disease.
    Title: Targeted radioiodine therapy of neuroblastoma tumors following systemic nonviral delivery of the sodium iodide symporter gene.
  3. The Na+/I- symporter mediates active iodide uptake in the intestine.
    Title: The Na+/I- symporter mediates active iodide uptake in the intestine.
  4. This study represents a promising first step in investigations of the potential use of a combination of the NIS gene and MDR1 shRNA as a new therapeutic strategy allowing RNA interference-based gene therapy.
    Title: Combination therapy and noninvasive imaging with a dual therapeutic vector expressing MDR1 short hairpin RNA and a sodium iodide symporter.
  5. Cloning of the mouse sodium iodide symporter.
    Title: Cloning of the mouse sodium iodide symporter.
  6. The high degree of homology in the 5'-flanking region between mouse and rat NIS suggests that mNIS and rNIS share similar mechanisms for transcriptional regulation in the thyroid.
    Title: Cloning of the 5'-flanking region of mouse sodium/iodide symporter and identification of a thyroid-specific and TSH-responsive enhancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables iodide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic anion:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium:iodide symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:iodide symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:iodide symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to Thyroid stimulating hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
  
involved_in iodide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iodide transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within iodide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iodide transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic anion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium/iodide cotransporter
Names
Na(+)/I(-) cotransporter
Na(+)/I(-) symporter
sodium-iodide symporter
solute carrier family 5 member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053248.2 → NP_444478.2  sodium/iodide cotransporter

    See identical proteins and their annotated locations for NP_444478.2

    Status: VALIDATED

    Source sequence(s)
    AC019302, AK046718, BB645718, CD741961
    Consensus CDS
    CCDS22385.1
    UniProtKB/Swiss-Prot
    B2RPX6, Q99PN0
    UniProtKB/TrEMBL
    G3X8P5
    Related
    ENSMUSP00000000809.3, ENSMUST00000000809.3
    Conserved Domains (1) summary
    cd11503
    Location:15 → 549
    SLC5sbd_NIS; Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71335529..71345429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509537.4 → XP_006509600.1  sodium/iodide cotransporter isoform X1

    UniProtKB/Swiss-Prot
    B2RPX6, Q99PN0
    Conserved Domains (1) summary
    cl00456
    Location:15 → 527
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_870460.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PN0.1 GenPept UniProtKB/Swiss-Prot:Q99PN0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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