Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chrna7provided by MGI
Official Full Name: cholinergic receptor, nicotinic, alpha polypeptide 7provided by MGI
Primary source: MGI:MGI:99779
See related: Ensembl:ENSMUSG00000030525 AllianceGenome:MGI:99779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acra7; nAchR; alpha7
Summary: Enables acetylcholine-gated cation-selective channel activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell communication; and regulation of protein metabolic process. Acts upstream of or within several processes, including behavioral response to ethanol; learning or memory; and negative regulation of cytokine production. Located in apical plasma membrane; axolemma; and external side of plasma membrane. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Is active in cholinergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 6.7), CNS E18 (RPKM 3.8) and 10 other tissues See more
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Genomic context

Location:: 7 C; 7 34.47 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (62748440..62862274, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (63098692..63212526, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha7 nicotinic receptors play a role in regulation of cardiac hemodynamics.
Title: α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.
alpha7nAChR activation in AT2 cells promotes alveolar regeneration through WNT7B signaling in acute lung injury.
Title: α7nAChR activation in AT2 cells promotes alveolar regeneration through WNT7B signaling in acute lung injury.
An ovarian phenotype of alpha 7 nicotinic receptor knockout mice.
Title: An ovarian phenotype of alpha 7 nicotinic receptor knockout mice.
Diminished alpha7 nicotinic acetylcholine receptor (alpha7nAChR) rescues amyloid-beta induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.
Title: Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.
Expression of the alpha7 nAChR Subunit Duplicate Form (CHRFAM7A) Was Down-Regulated in Patients with Intracranial Infection and Reduced Inflammation in in vitro Model by p38 MAPK.
Title: Expression of the α7 nAChR Subunit Duplicate Form (CHRFAM7A) Was Down-Regulated in Patients with Intracranial Infection and Reduced Inflammation in in vitro Model by p38 MAPK.
A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice.
Title: A role of gut-microbiota-brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice.
Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway.
Title: Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway.
Activation of the alpha7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.
Title: Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.
Microglial cell response in alpha7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.
Title: Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.
Activation of alpha-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.
Title: Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (232)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fi15f09.x1 (e-PCR)
- UniSTS:196884

D7Mit176 (e-PCR), detects polymorphism
- UniSTS:116337

NoName (e-PCR)
- UniSTS:224382

L37663 (e-PCR)
- UniSTS:159651

Chrna7 (e-PCR), detects polymorphism
- UniSTS:256425

Chrna7 (e-PCR), detects polymorphism
- UniSTS:141005

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables chloride channel regulator activity	ISO Inferred from Sequence Orthology more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within associative learning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral response to nicotine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of ovulation cycle rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovulation cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CoA-transferase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid fibril formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to drug	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse structural plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acetylcholine	ISO Inferred from Sequence Orthology more info
involved_in response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cold	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to food	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in sensory processing	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory processing	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic transmission, cholinergic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cholinergic synapse	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	TAS Traceable Author Statement more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in spine apparatus membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuronal acetylcholine receptor subunit alpha-7

Names: acetylcholine receptor alpha 7 neural; alpha7 nicotinic receptor; alpha7-nAChR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007390.3 → NP_031416.3 neuronal acetylcholine receptor subunit alpha-7 precursor

See identical proteins and their annotated locations for NP_031416.3

Status: VALIDATED

Source sequence(s)

AK034208, AK157809, BY727569

Consensus CDS

CCDS21329.1

UniProtKB/Swiss-Prot

P49582

UniProtKB/TrEMBL

Q53YJ9, Q9JHD6

Related

ENSMUSP00000032738.6, ENSMUST00000032738.7

Conserved Domains (3) summary

TIGR00860
Location:4 → 490

LIC; Cation transporter family protein

pfam02931
Location:26 → 230

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:237 → 486

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region