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Acp1 acid phosphatase 1, soluble [ Mus musculus (house mouse) ]

Gene ID: 11431, updated on 25-Apr-2024

Summary

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Official Symbol
Acp1provided by MGI
Official Full Name
acid phosphatase 1, solubleprovided by MGI
Primary source
MGI:MGI:87881
See related
Ensembl:ENSMUSG00000044573 AllianceGenome:MGI:87881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acp-1; Lmptp; LMW-PTP; 4632432E04Rik
Summary
Enables acid phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytosol and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 16.3), liver E14.5 (RPKM 13.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A2; 12 13.0 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30943325..30961616, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30893326..30911619, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11506 Neighboring gene transmembrane protein 18 Neighboring gene STARR-seq mESC enhancer starr_31844 Neighboring gene predicted gene, 32320 Neighboring gene STARR-seq mESC enhancer starr_31845 Neighboring gene STARR-positive B cell enhancer ABC_E7128 Neighboring gene ALK and LTK ligand 2 Neighboring gene Sh3 domain YSC-like 1 Neighboring gene STARR-seq mESC enhancer starr_31846 Neighboring gene pyruvate kinase, muscle pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice. Jensen-Cody S, et al. Am J Physiol Endocrinol Metab, 2022 Jun 1. PMID 35403438
  2. The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy. Stanford SM, et al. J Cell Physiol, 2021 Sep. PMID 33615467, Free PMC Article
  3. Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP. Fernandes GV, et al. J Cell Biochem, 2014 Jun. PMID 24123071
  4. Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation. Chiarugi P, et al. J Biol Chem, 2002 Oct 4. PMID 12149261
  5. Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading. Rigacci S, et al. J Biol Chem, 2002 Nov 1. PMID 12055185

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy.
    Title: The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy.
  2. Our data show that ablation of Lmptp inhibits pathological cardiac remodelling
    Title: Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
  3. Data indicate there was no significant change in low molecular weight protein tyrosine phosphatase (LMW-PTP) expression at 30 min or 2 h.
    Title: Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP.
  4. The expression and activity of Src and low molecular weight protein tyrosine phosphatase (LMWPTP) during osteoblast differentiation was examined and the modulation of Src kinase by LMWPTP was assessed.
    Title: Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation.
  5. low M(r) phosphotyrosine protein phosphatase participation in FAK-mediated focal adhesion remodeling.
    Title: Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading.
  6. The formation of LMW-PTP/caveolin-1 complexes is accompanied by modulation of the enzyme activities, and the inhibitory effect elicited against IF1 is stronger than that against IF2
    Title: Low molecular weight protein tyrosine phosphatase and caveolin-1: interaction and isoenzyme-dependent regulation.
  7. plays a role on PDGF receptor signaling and controls PDGF-r kinase activity through TYR-857 dephosphorylation
    Title: Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation.
  8. The redox-dependent enhancement of Grb2 recruitment to LMW-PTP ultimately leads to an improvement of ERK activation, likely triggering a prosurvival signal against the oxidant environment.
    Title: A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103115, MGC132904

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables acid phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
low molecular weight phosphotyrosine protein phosphatase
Names
LMW-PTPase
low molecular weight cytosolic acid phosphatase
NP_001103709.1
NP_067305.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110239.1 → NP_001103709.1  low molecular weight phosphotyrosine protein phosphatase isoform 1

    See identical proteins and their annotated locations for NP_001103709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1, also known as IF2).
    Source sequence(s)
    AC160932, AK014603, AK152429
    Consensus CDS
    CCDS49045.1
    UniProtKB/TrEMBL
    Q561M1
    Related
    ENSMUSP00000073686.6, ENSMUST00000074038.7
    Conserved Domains (1) summary
    cd16343
    Location:7 → 155
    LMWPTP; Low molecular weight protein tyrosine phosphatase

  2. NM_021330.4 → NP_067305.2  low molecular weight phosphotyrosine protein phosphatase isoform 2

    See identical proteins and their annotated locations for NP_067305.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2, also known as IF1) is the same length as isoform 1 but differs at an internal region, compared to isoform 1.
    Source sequence(s)
    AC160932, AK082955
    Consensus CDS
    CCDS36427.1
    UniProtKB/Swiss-Prot
    O88739, O88740, Q9D358, Q9QWF5
    UniProtKB/TrEMBL
    Q4VAI2
    Related
    ENSMUSP00000106509.4, ENSMUST00000062740.15
    Conserved Domains (1) summary
    cd00115
    Location:7 → 155
    LMWPc; Low molecular weight phosphatase family;

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    30943325..30961616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_381176.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D358.3 GenPept UniProtKB/Swiss-Prot:Q9D358

Gene LinkOut

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