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LACTB lactamase beta [ Homo sapiens (human) ]

Gene ID: 114294, updated on 5-Mar-2024

Summary

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Official Symbol
LACTBprovided by HGNC
Official Full Name
lactamase betaprovided by HGNC
Primary source
HGNC:HGNC:16468
See related
Ensembl:ENSG00000103642 MIM:608440; AllianceGenome:HGNC:16468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G24; MRPL56
Summary
This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 9.0), adrenal (RPKM 7.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
15q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (63121861..63142061)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (60926721..60946916)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63414060..63434260)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6507 Neighboring gene TPM1 antisense RNA Neighboring gene tropomyosin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63370949-63371626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63371627-63372302 Neighboring gene VISTA enhancer hs2160 Neighboring gene Sharpr-MPRA regulatory region 14461 Neighboring gene uncharacterized LOC107984798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6510 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:63448416-63449615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6511 Neighboring gene ribosomal protein S27 like Neighboring gene uncharacterized LOC101928972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6512

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding. Bennett JA, et al. PLoS Biol, 2022 Dec. PMID 36534696, Free PMC Article
  2. LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer. Gonzalez-Morena JM, et al. Apoptosis, 2023 Feb. PMID 36282364, Free PMC Article
  3. LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway. Hu Y, et al. Biochem Biophys Res Commun, 2022 Nov 12. PMID 36088805
  4. Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB. Zhang M, et al. Structure, 2022 May 5. PMID 35247327
  5. [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines]. Liu ZY, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2021 Aug. PMID 34362477

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
    Title: OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
  2. PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
    Title: PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
  3. LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.
    Title: LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.
  4. The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.
    Title: The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.
  5. Clinical Significance of beta-Lactamase Expression in Colorectal Cancer.
    Title: Clinical Significance of β-Lactamase Expression in Colorectal Cancer.
  6. LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.
    Title: LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.
  7. LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway.
    Title: LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway.
  8. Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
    Title: Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
  9. LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.
    Title: LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.
  10. [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines].
    Title: [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines].
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14902

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine beta-lactamase-like protein LACTB, mitochondrial
Names
mitochondrial 39S ribosomal protein L56
serine beta-lactamase-like protein, mitochondrial

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050565.1 RefSeqGene

    Range
    5062..25262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288585.2 → NP_001275514.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 3' coding region and 3' UTR, compared to variant 1, one of which results in a frameshift. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA186367, AC087612, AK027808, BC037198
    UniProtKB/Swiss-Prot
    P83111
    Conserved Domains (1) summary
    pfam00144
    Location:112 → 223
    Beta-lactamase; Beta-lactamase

  2. NM_032857.5 → NP_116246.2  serine beta-lactamase-like protein LACTB, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_116246.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC067288
    Consensus CDS
    CCDS10182.1
    UniProtKB/Swiss-Prot
    P83096, P83111
    Related
    ENSP00000261893.4, ENST00000261893.9
    Conserved Domains (1) summary
    pfam00144
    Location:112 → 524
    Beta-lactamase; Beta-lactamase

  3. NM_171846.4 → NP_741982.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_741982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 3' coding exon and its 3' terminal exon extends past a splice site that it used in variant 1, resulting in a distinct 3' UTR. The encoded isoform (b) has a shorter C-terminus than isoform a.
    Source sequence(s)
    AA186367, AC087612, AK027808, AY358709, BC037198
    Consensus CDS
    CCDS45275.1
    UniProtKB/Swiss-Prot
    P83111
    Related
    ENSP00000392956.2, ENST00000413507.3
    Conserved Domains (1) summary
    pfam00144
    Location:112 → 356
    Beta-lactamase; Beta-lactamase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    63121861..63142061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432128.1 → XP_047288084.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    60926721..60946916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377234.1 → XP_054233209.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83111.2 GenPept UniProtKB/Swiss-Prot:P83111

Gene LinkOut

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