Apoc4 apolipoprotein C-IV [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apoc4provided by MGI
Official Full Name: apolipoprotein C-IVprovided by MGI
Primary source: MGI:MGI:87878
See related: Ensembl:ENSMUSG00000074336 AllianceGenome:MGI:87878
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acl; apo-CIV; apoC-IV
Summary: Predicted to be involved in positive regulation of sequestering of triglyceride and triglyceride homeostasis. Predicted to act upstream of or within lipid transport. Part of very-low-density lipoprotein particle. Is expressed in liver. Orthologous to human APOC4 (apolipoprotein C4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 1196.5) and liver E18 (RPKM 452.1) See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.94 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19412009..19415385, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19678084..19681460, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

regulated exprsesion of gene cluster in macrophages
Title: Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2) 1 citation

General gene information

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Readthrough Apoc2l

Readthrough gene: Apoc2l, Included gene: Apoc2

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sequestering of triglyceride	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein C-IV

Names: apolipoprotein C2-linked; apolipoprotein C4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.