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FAM83F family with sequence similarity 83 member F [ Homo sapiens (human) ]

Gene ID: 113828, updated on 5-Mar-2024

Summary

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Official Symbol
FAM83Fprovided by HGNC
Official Full Name
family with sequence similarity 83 member Fprovided by HGNC
Primary source
HGNC:HGNC:25148
See related
Ensembl:ENSG00000133477 AllianceGenome:HGNC:25148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 11.4), skin (RPKM 5.5) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
22q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (39994954..40043534)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (40465916..40515097)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (40390958..40439538)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene GRB2 related adaptor protein 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:40361232-40361409 Neighboring gene uncharacterized LOC124905155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40390673-40391306 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:40393419-40394024 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:40394025-40394630 Neighboring gene translation machinery associated 7 homolog B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40401347-40401848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40401849-40402348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40418684-40419184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40419185-40419685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19079 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40426725-40427244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:40439529-40440176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13767 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:40442874-40443092 Neighboring gene TNRC6B divergent transcript Neighboring gene trinucleotide repeat containing adaptor 6B Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:40497428-40497948 Neighboring gene ribosomal protein L7 pseudogene 52 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19082 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40591286-40591820 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40591821-40592353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40624195-40624696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40633809-40634710 Neighboring gene uncharacterized LOC124905121

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Highly Expressed FAM83F Protein in Papillary Thyroid Cancer Exerts a Pro-Oncogenic Role in Thyroid Follicular Cells. Fuziwara CS, et al. Front Endocrinol (Lausanne), 2019. PMID 30881348, Free PMC Article
  2. Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis. Tai G, et al. Exp Lung Res, 2021 Apr. PMID 33560141
  3. FAM83F regulates canonical Wnt signalling through an interaction with CK1α. Dunbar K, et al. Life Sci Alliance, 2021 Feb. PMID 33361109, Free PMC Article
  4. MiR-650 inhibits the progression of glioma by targeting FAM83F. Xu L, et al. Eur Rev Med Pharmacol Sci, 2018 Dec. PMID 30556880
  5. MiR-940 inhibits the progression of NSCLC by targeting FAM83F. Gu GM, et al. Eur Rev Med Pharmacol Sci, 2018 Sep. PMID 30280778

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis.
    Title: Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis.
  2. FAM83F regulates canonical Wnt signalling through an interaction with CK1alpha.
    Title: FAM83F regulates canonical Wnt signalling through an interaction with CK1α.
  3. MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by targeting MYC and FAM83F.
    Title: MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by targeting MYC and FAM83F.
  4. Fam83F induces p53 stabilisation and promotes its activity.
    Title: Fam83F induces p53 stabilisation and promotes its activity.
  5. Results show that FAM83F expression was distinctly upregulated in non-small cell lung cancer (NSCLC) tissues. MiR-940 inhibited the proliferation of cancer cells by targeting FAM83F and further restrained the progression of NSCLC.
    Title: MiR-940 inhibits the progression of NSCLC by targeting FAM83F.
  6. Low MiR-650 expression in glioma cells promotes tumor cell proliferation by up-regulating the expression of FAM83F.
    Title: MiR-650 inhibits the progression of glioma by targeting FAM83F.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44317

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein FAM83F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138435.4 → NP_612444.2  protein FAM83F

    See identical proteins and their annotated locations for NP_612444.2

    Status: VALIDATED

    Source sequence(s)
    KF457465, Z82206, Z83847
    Consensus CDS
    CCDS14000.2
    UniProtKB/Swiss-Prot
    Q8NEG4, Q96FD6
    Related
    ENSP00000330432.5, ENST00000333407.11
    Conserved Domains (2) summary
    cd09186
    Location:20 → 295
    PLDc_FAM83F_N; N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83F
    pfam13091
    Location:154 → 291
    PLDc_2; PLD-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    39994954..40043534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    40465916..40515097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_039988.1: Suppressed sequence

    Description
    NR_039988.1: This RefSeq was removed because the gene was discontinued.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEG4.1 GenPept UniProtKB/Swiss-Prot:Q8NEG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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