AZIN2 antizyme inhibitor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: AZIN2provided by HGNC
Official Full Name: antizyme inhibitor 2provided by HGNC
Primary source: HGNC:HGNC:29957
See related: Ensembl:ENSG00000142920 MIM:608353; AllianceGenome:HGNC:29957
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADC; AZI2; ODCp; AZIB1; ODC-p; ODC1L
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
Expression: Broad expression in testis (RPKM 8.2), brain (RPKM 4.1) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p35.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (33081153..33166795)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (32941046..33025345)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (33546754..33589093)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced anti-tumor activity of arginine decarboxylase through the incorporation of aromatic amino acids at the multimer-forming interface.
Title: Enhanced anti-tumor activity of arginine decarboxylase through the incorporation of aromatic amino acids at the multimer-forming interface.
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Title: Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma.
Title: Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma.
AZIN2 splice variant suppressed endogenous cardiac regeneration by targeting the PTEN/Akt pathway.
Title: Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.
The morphological change induced by hADC gene delivery was the expression levels of adhesion molecules, N-CAM and integrin and showed modulation of brain-derived neurotrophic factor (BDNF), phosphoinositide 3-kinase (PI3K) and ERK1/2 expressions.
Title: Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells.
The high expression of AZIN2 in various cells with secretory or vesicle transport activity indicates that the polyamine metabolism regulated by AZIN2
Title: Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues.
ODC activity is mostly linked to cell proliferation, whereas its regulation by AZIN2 in post-mitotically differentiated neurons of the brain apparently serves different purposes.
Title: Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease.
Both endogenous and FLAG-tagged AZIN2 localize to post-Golgi vesicles of the secretory pathway. Immuno-electron microscopy revealed that the vesicles associate mainly with the trans-Golgi network.
Title: Ornithine decarboxylase antizyme inhibitor 2 regulates intracellular vesicle trafficking.
AZIN2 expression appears to be restricted to brain and testis and it is a labile protein degraded by a ubiquitin-dependent mechanism.
Title: Antizyme inhibitor 2: molecular, cellular and physiological aspects.
localization of AZIN2 implies possible involvement in the gonadal synthesis and/or release of steroid hormones.
Title: High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adc (e-PCR), detects polymorphism
- UniSTS:531464

SHGC-74543 (e-PCR)
- UniSTS:22313

SHGC-74540 (e-PCR)
- UniSTS:13159

D1S1259 (e-PCR)
- UniSTS:149456

SHGC-74552 (e-PCR)
- UniSTS:30204

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables arginine decarboxylase activity	TAS Traceable Author Statement more info
enables ornithine decarboxylase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables ornithine decarboxylase activator activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables ornithine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in agmatine biosynthetic process	TAS Traceable Author Statement more info
involved_in negative regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of catalytic activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of catalytic activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of polyamine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in putrescine biosynthetic process from ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in trans-Golgi network membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in granular vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: antizyme inhibitor 2

Names: ODC antizyme inhibitor-2; ODC-like protein; ODC-paralogue; arginine decarboxylase; ornithine decarboxylase like; ornithine decarboxylase-like protein; ornithine decarboxylase-paralog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293562.2 → NP_001280491.1 antizyme inhibitor 2 isoform 1

See identical proteins and their annotated locations for NP_001280491.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AL020995, AW450278, BC010449, BC028128

Consensus CDS

CCDS375.1

UniProtKB/Swiss-Prot

B2RDU5, D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96A70, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9

Related

ENSP00000362542.3, ENST00000373443.7

Conserved Domains (1) summary

cd00622
Location:40 → 408

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001301823.2 → NP_001288752.1 antizyme inhibitor 2 isoform 2

See identical proteins and their annotated locations for NP_001288752.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple differences at the 5' end, which result in a distinct 5' UTR and translation initiation from an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3, 4, 8, 9, 10 and 11 encode the same isoform (2).

Source sequence(s)

AK095127, AL020995, AW450278, DB456925

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001301824.2 → NP_001288753.1 antizyme inhibitor 2 isoform 2

See identical proteins and their annotated locations for NP_001288753.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has multiple differences at the 5' end, which result in a distinct 5' UTR and translation initiation from an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3, 4, 8, 9, 10 and 11 encode the same isoform (2).

Source sequence(s)

AK057051, AL020995, AW450278, DB456925

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001301825.1 → NP_001288754.1 antizyme inhibitor 2 isoform 3

See identical proteins and their annotated locations for NP_001288754.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as SV2) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting isoform (3) is longer containing a 20 aa protein segment not found in isoform 1.

Source sequence(s)

AW450278, AY050635, BC028128

Consensus CDS

CCDS76138.1

UniProtKB/Swiss-Prot

Q96A70

Related

ENSP00000362540.1, ENST00000373441.1

Conserved Domains (1) summary

cd00622
Location:40 → 428

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001301826.1 → NP_001288755.1 antizyme inhibitor 2 isoform 4

See identical proteins and their annotated locations for NP_001288755.1

Status: REVIEWED

Description

Transcript Variant: This variant (6, also known as SV3) contains a different 3' terminal exon compared to variant 1. The encoded isoform (4) is shorter with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AY050637, BC028128

UniProtKB/Swiss-Prot

Q96A70

Conserved Domains (1) summary

cd00622
Location:40 → 353

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001350398.2 → NP_001337327.1 antizyme inhibitor 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences at the 5' end, which result in a distinct 5' UTR and translation initiation from an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3, 4, 8, 9, 10 and 11 encode the same isoform (2).

Source sequence(s)

AK095127, AL020995, AW450278, BC028128, BX444560, DB476211

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001350399.2 → NP_001337328.1 antizyme inhibitor 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences at the 5' end, which result in a distinct 5' UTR and translation initiation from an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3, 4, 8, 9, 10 and 11 encode the same isoform (2).

Source sequence(s)

AK095127, AL020995, AW450278, BC028128, BX444560, DB456925, DB476211

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001350400.2 → NP_001337329.1 antizyme inhibitor 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (10) has multiple differences at the 5' end, which result in a distinct 5' UTR and translation initiation from an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3, 4, 8, 9, 10 and 11 encode the same isoform (2).

Source sequence(s)

AK095127, AL020995, AW450278, BC028128, BX444560, DB476211

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001350401.2 → NP_001337330.1 antizyme inhibitor 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (11) has multiple differences at the 5' end, which result in a distinct 5' UTR and translation initiation from an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3, 4, 8, 9, 10 and 11 encode the same isoform (2).

Source sequence(s)

AK095127, AL020995, AW450278, BC028128, BX444560, DB476211

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001350402.1 → NP_001337331.1 antizyme inhibitor 2 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (12) has multiple differences at the 5' end, which result in a distinct 5' UTR and translation initiation from an in-frame downstream start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK095127, AL020995, AW450278, BX444560, DB476211, R15361

UniProtKB/TrEMBL

B3KV62

Conserved Domains (1) summary

cl00261
Location:1 → 257

PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes
NM_001376722.1 → NP_001363651.1 antizyme inhibitor 2 isoform 1

Status: REVIEWED

Source sequence(s)

AL020995

Consensus CDS

CCDS375.1

UniProtKB/Swiss-Prot

B2RDU5, D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96A70, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9

Conserved Domains (1) summary

cd00622
Location:40 → 408

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001376724.1 → NP_001363653.1 antizyme inhibitor 2 isoform 1

Status: REVIEWED

Source sequence(s)

AL020995

Consensus CDS

CCDS375.1

UniProtKB/Swiss-Prot

B2RDU5, D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96A70, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9

Conserved Domains (1) summary

cd00622
Location:40 → 408

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001376725.1 → NP_001363654.1 antizyme inhibitor 2 isoform 2

Status: REVIEWED

Source sequence(s)

AL020995

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001376727.1 → NP_001363656.1 antizyme inhibitor 2 isoform 2

Status: REVIEWED

Source sequence(s)

AL020995

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001376729.1 → NP_001363658.1 antizyme inhibitor 2 isoform 2

Status: REVIEWED

Source sequence(s)

AL020995

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001376730.1 → NP_001363659.1 antizyme inhibitor 2 isoform 6

Status: REVIEWED

Source sequence(s)

AL020995

Conserved Domains (1) summary

cd00622
Location:21 → 350

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
NM_001376732.1 → NP_001363661.1 antizyme inhibitor 2 isoform 5

Status: REVIEWED

Source sequence(s)

AL020995

UniProtKB/TrEMBL

B3KV62

Conserved Domains (1) summary

cl00261
Location:1 → 257

PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes
NM_052998.4 → NP_443724.1 antizyme inhibitor 2 isoform 1

See identical proteins and their annotated locations for NP_443724.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the predominant isoform (1). Variants 1 and 2 encode the same isoform.

Source sequence(s)

AL020995, AW450278, BC028128

Consensus CDS

CCDS375.1

UniProtKB/Swiss-Prot

B2RDU5, D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96A70, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9

Related

ENSP00000294517.6, ENST00000294517.11

Conserved Domains (1) summary

cd00622
Location:40 → 408

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

RNA

NR_126031.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7, also known as SV4) uses an alternate acceptor splice site at an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK122697, AY050636, BC028128
NR_146648.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (13) contains multiple differences compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK095127, AL020995, AW450278, AY050637, BC028128, BX444560, DB456925, DB476211
NR_146649.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (14) contains multiple differences at internal exons compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL020995, AW450278, BC010449, BC028128, R15361

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

33081153..33166795

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047443457.1 → XP_047299413.1 antizyme inhibitor 2 isoform X3
XM_017000174.2 → XP_016855663.1 antizyme inhibitor 2 isoform X6

Conserved Domains (1) summary

cd00622
Location:40 → 305

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
XM_011540557.2 → XP_011538859.1 antizyme inhibitor 2 isoform X1

See identical proteins and their annotated locations for XP_011538859.1

Conserved Domains (1) summary

cd00622
Location:21 → 350

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
XM_017000175.2 → XP_016855664.1 antizyme inhibitor 2 isoform X4

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
XM_024452818.2 → XP_024308586.1 antizyme inhibitor 2 isoform X4

Conserved Domains (1) summary

cd00622
Location:1 → 313

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
XM_047443450.1 → XP_047299406.1 antizyme inhibitor 2 isoform X2
XM_011540566.2 → XP_011538868.1 antizyme inhibitor 2 isoform X7

Conserved Domains (1) summary

cd00622
Location:40 → 305

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
XM_011540563.2 → XP_011538865.1 antizyme inhibitor 2 isoform X5

See identical proteins and their annotated locations for XP_011538865.1

UniProtKB/Swiss-Prot

Q96A70

Conserved Domains (1) summary

cd00622
Location:40 → 353

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase
XM_047443473.1 → XP_047299429.1 antizyme inhibitor 2 isoform X5
XM_047443474.1 → XP_047299430.1 antizyme inhibitor 2 isoform X5