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SCRG1 stimulator of chondrogenesis 1 [ Homo sapiens (human) ]

Gene ID: 11341, updated on 3-Apr-2024

Summary

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Official Symbol
SCRG1provided by HGNC
Official Full Name
stimulator of chondrogenesis 1provided by HGNC
Primary source
HGNC:HGNC:17036
See related
Ensembl:ENSG00000164106 MIM:603163; AllianceGenome:HGNC:17036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCRG-1; lincSCRG1
Summary
Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]
Expression
Biased expression in brain (RPKM 46.0), testis (RPKM 30.3) and 3 other tissues See more
Orthologs
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Genomic context

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Location:
4q34.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (173384701..173519144, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (176724109..176858933, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174305852..174440295, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SAP30 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:174292649-174293212 Neighboring gene uncharacterized LOC112268474 Neighboring gene Sin3A associated protein 30 Neighboring gene 60S ribosomal protein L38-like Neighboring gene NANOG hESC enhancer GRCh37_chr4:174356204-174356706 Neighboring gene ribosomal protein L5 pseudogene 11 Neighboring gene VISTA enhancer hs2501 Neighboring gene RNA, U6 small nuclear 1096, pseudogene Neighboring gene uncharacterized LOC112267917 Neighboring gene NANOG hESC enhancer GRCh37_chr4:174410607-174411181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22160 Neighboring gene uncharacterized LOC101928409 Neighboring gene uncharacterized LOC124900815 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:174439311-174440510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:174445895-174446436 Neighboring gene uncharacterized LOC124900816 Neighboring gene NANOG hESC enhancer GRCh37_chr4:174457885-174458386 Neighboring gene HAND2 antisense RNA 1 Neighboring gene heart and neural crest derivatives expressed 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of SCRG1 as a Potential Therapeutic Target for Human Synovial Inflammation. Liu G, et al. Front Immunol, 2022. PMID 35720295, Free PMC Article
  2. A predominantly articular cartilage-associated gene, SCRG1, is induced by glucocorticoid and stimulates chondrogenesis in vitro. Ochi K, et al. Osteoarthritis Cartilage, 2006 Jan. PMID 16188469
  3. linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin. Wu JC, et al. FASEB J, 2019 Feb. PMID 30226813
  4. Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro. Yuan R, et al. Molecules, 2023 Jan 28. PMID 36770940, Free PMC Article
  5. Haploinsufficiency of the basic helix-loop-helix transcription factor HAND2 causes congenital heart defects. Cohen ASA, et al. Am J Med Genet A, 2020 May. PMID 32134193

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro.
    Title: Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro.
  2. Identification of SCRG1 as a Potential Therapeutic Target for Human Synovial Inflammation.
    Title: Identification of SCRG1 as a Potential Therapeutic Target for Human Synovial Inflammation.
  3. Haploinsufficiency of the basic helix-loop-helix transcription factor HAND2 causes congenital heart defects.
    Title: Haploinsufficiency of the basic helix-loop-helix transcription factor HAND2 causes congenital heart defects.
  4. High lncRNA in SCRG1 gene expression is associated with liver fibrosis.
    Title: linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin.
  5. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.
    Title: Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.
  6. Aomatsu et al. identified a novel SCRG1/BST1 (CD157) ligand-receptor combination that maintains human mesenchymal stem cells expressions of stem cell markers Oct-4 and CD271 (LNGFR), as well as self-renewal, migration, and osteogenic differentiation potentials during ex vivo expansion.
    Title: Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26468

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 
is_active_in neuron projection terminus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
scrapie-responsive protein 1
Names
scrapie responsive gene 1
scrapie-responsive gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329597.2 → NP_001316526.1  scrapie-responsive protein 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC093849, AC097534
    Consensus CDS
    CCDS3818.1
    UniProtKB/Swiss-Prot
    O75711
    UniProtKB/TrEMBL
    D3DP39, D6RD99, Q6FGG5
    Conserved Domains (1) summary
    pfam15224
    Location:22 → 97
    SCRG1; Scrapie-responsive protein 1

  2. NM_007281.4 → NP_009212.1  scrapie-responsive protein 1 precursor

    See identical proteins and their annotated locations for NP_009212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC097534, AJ224677
    Consensus CDS
    CCDS3818.1
    UniProtKB/Swiss-Prot
    O75711
    UniProtKB/TrEMBL
    D3DP39, D6RD99, Q6FGG5
    Related
    ENSP00000296506.2, ENST00000296506.8
    Conserved Domains (1) summary
    pfam15224
    Location:22 → 97
    SCRG1; Scrapie-responsive protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    173384701..173519144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449563.1 → XP_047305519.1  scrapie-responsive protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O75711
    UniProtKB/TrEMBL
    D3DP39, Q6FGG5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    176724109..176858933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348845.1 → XP_054204820.1  scrapie-responsive protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O75711
    UniProtKB/TrEMBL
    D3DP39, Q6FGG5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75711.1 GenPept UniProtKB/Swiss-Prot:O75711

Gene LinkOut

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