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Aatk apoptosis-associated tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 11302, updated on 3-Apr-2024

Summary

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Official Symbol
Aatkprovided by MGI
Official Full Name
apoptosis-associated tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:1197518
See related
Ensembl:ENSMUSG00000025375 AllianceGenome:MGI:1197518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AATYK; aatyk1; mKIAA0641
Summary
Enables protein tyrosine kinase activity. Acts upstream of or within several processes, including Rab protein signal transduction; nervous system development; and peptidyl-tyrosine autophosphorylation. Located in several cellular components, including axonal growth cone; perinuclear region of cytoplasm; and recycling endosome. Is expressed in brain. Orthologous to human AATK (apoptosis associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 51.8), cortex adult (RPKM 38.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 83.96 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119898137..119938009, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120007311..120047183, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31337 Neighboring gene STARR-positive B cell enhancer ABC_E2379 Neighboring gene predicted gene 11767 Neighboring gene predicted gene, 57802 Neighboring gene brain-specific angiogenesis inhibitor 1-associated protein 2 Neighboring gene microRNA 3065 Neighboring gene microRNA 338 Neighboring gene centrosomal protein 131 Neighboring gene STARR-positive B cell enhancer ABC_E4021 Neighboring gene STARR-positive B cell enhancer ABC_E206 Neighboring gene TEPSIN, adaptor related protein complex 4 accessory protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hyperactive and impulsive behaviors of LMTK1 knockout mice. Takahashi M, et al. Sci Rep, 2020 Sep 22. PMID 32963255, Free PMC Article
  2. Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer. Ding LY, et al. Clin Epigenetics, 2020 Jun 17. PMID 32552862, Free PMC Article
  3. Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation. Wei R, et al. J Biochem, 2020 Jul 1. PMID 32044995
  4. Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma. Ma S, et al. Lab Invest, 2014 Apr. PMID 24589855
  5. Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation. Gagnon KB, et al. Am J Physiol Cell Physiol, 2007 May. PMID 17267545

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer.
    Title: Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer.
  2. Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation.
    Title: Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation.
  3. The results showed that AATYK knockdown inhibited Oligodendrocytes differentiation and the expression of myelin genes in vitro.
    Title: AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.
  4. LMTK1 negatively controls dendritic formation by regulating Rab11A-positive endosomal trafficking.
    Title: LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes.
  5. Overexpression of the unphosphorylated mutant LMTK1-S34A dramatically promotes axonal outgrowth in cultured neurons.
    Title: LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner.
  6. results suggest a possibility that AATYK1A plays a role in early to recycling endosomes and its function is regulated by phosphorylation with Cdk5 or Src-family kinases
    Title: Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.
  7. Expression of AATYK mRNA and protein increased during postnatal brain development. In immature granule cells, overexpression of AATYK promoted neurite outgrowth; a tyrosine kinase-defective mutant significantly inhibited it.
    Title: Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain.
  8. AATYK1 indirectly inhibits the SPAK/WNK4 activation of the Na-K-2Cl cotransporter by scaffolding an inhibitory phosphatase in proximity to a stimulatory kinase.
    Title: Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation.
  9. phosphorylation states of AATYK are closely related to the high potassium-induced survival and low potassium-induced apoptosis of cerebellar granule cells
    Title: Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase LMTK1
Names
apoptosis-associated tyrosine kinase 1B
brain apoptosis-associated tyrosine kinase
lemur tyrosine kinase 1
NP_001185714.1
NP_001185716.1
NP_001364432.1
NP_001389718.1
NP_031403.2
XP_006532054.1
XP_006532055.1
XP_006532056.1
XP_006532057.1
XP_036012124.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198785.1 → NP_001185714.1  serine/threonine-protein kinase LMTK1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains an in-frame upstream start codon compared to variant 1. This variant encodes a protein (isoform 2) with a longer N-terminus than isoform 1.
    Source sequence(s)
    AB288871, BC042837, BC080846
    Consensus CDS
    CCDS56826.1
    UniProtKB/Swiss-Prot
    A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    UniProtKB/TrEMBL
    B1AZF3
    Related
    ENSMUSP00000067181.4, ENSMUST00000064307.10
    Conserved Domains (3) summary
    smart00221
    Location:138 → 405
    STYKc; Protein kinase; unclassified specificity
    cd05087
    Location:137 → 407
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    pfam12429
    Location:828 → 880
    DUF3676; Protein of unknown function (DUF3676)

  2. NM_001198787.1 → NP_001185716.1  serine/threonine-protein kinase LMTK1 isoform 1

    See identical proteins and their annotated locations for NP_001185716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant, and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK036705, BC080846
    Consensus CDS
    CCDS25725.1
    UniProtKB/Swiss-Prot
    A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    UniProtKB/TrEMBL
    B1AZF9
    Related
    ENSMUSP00000099308.2, ENSMUST00000103019.2
    Conserved Domains (3) summary
    smart00221
    Location:81 → 348
    STYKc; Protein kinase; unclassified specificity
    cd05087
    Location:80 → 350
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    pfam12429
    Location:771 → 823
    DUF3676; Protein of unknown function (DUF3676)

  3. NM_001377503.1 → NP_001364432.1  serine/threonine-protein kinase LMTK1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL953913
    UniProtKB/Swiss-Prot
    A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    Conserved Domains (2) summary
    PHA03307
    Location:473 → 904
    PHA03307; transcriptional regulator ICP4; Provisional
    cl21453
    Location:1 → 230
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001402789.1 → NP_001389718.1  serine/threonine-protein kinase LMTK1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL953913

  5. NM_007377.4 → NP_031403.2  serine/threonine-protein kinase LMTK1 isoform 1

    See identical proteins and their annotated locations for NP_031403.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    BC042837, BC080846
    Consensus CDS
    CCDS25725.1
    UniProtKB/Swiss-Prot
    A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    UniProtKB/TrEMBL
    B1AZF9
    Related
    ENSMUSP00000099309.2, ENSMUST00000103020.8
    Conserved Domains (3) summary
    smart00221
    Location:81 → 348
    STYKc; Protein kinase; unclassified specificity
    cd05087
    Location:80 → 350
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    pfam12429
    Location:771 → 823
    DUF3676; Protein of unknown function (DUF3676)

RNA

  1. NR_165305.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL953913

  2. NR_165306.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL953913

  3. NR_175298.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL953913

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119898137..119938009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531991.3 → XP_006532054.1  serine/threonine-protein kinase LMTK1 isoform X1

    UniProtKB/Swiss-Prot
    A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    Conserved Domains (2) summary
    PHA03307
    Location:650 → 1081
    PHA03307; transcriptional regulator ICP4; Provisional
    cd05087
    Location:137 → 407
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

  2. XM_006531993.3 → XP_006532056.1  serine/threonine-protein kinase LMTK1 isoform X4

    See identical proteins and their annotated locations for XP_006532056.1

    UniProtKB/Swiss-Prot
    A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    Related
    ENSMUST00000150730.8
    Conserved Domains (2) summary
    PHA03307
    Location:593 → 1024
    PHA03307; transcriptional regulator ICP4; Provisional
    cd05087
    Location:80 → 350
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

  3. XM_006531994.4 → XP_006532057.1  serine/threonine-protein kinase LMTK1 isoform X4

    See identical proteins and their annotated locations for XP_006532057.1

    UniProtKB/Swiss-Prot
    A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    Conserved Domains (2) summary
    PHA03307
    Location:593 → 1024
    PHA03307; transcriptional regulator ICP4; Provisional
    cd05087
    Location:80 → 350
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

  4. XM_006531992.5 → XP_006532055.1  serine/threonine-protein kinase LMTK1 isoform X2

    UniProtKB/Swiss-Prot
    A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    Conserved Domains (2) summary
    PHA03307
    Location:601 → 1032
    PHA03307; transcriptional regulator ICP4; Provisional
    cd05087
    Location:88 → 358
    PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

  5. XM_036156231.1 → XP_036012124.1  serine/threonine-protein kinase LMTK1 isoform X5

    Related
    ENSMUST00000142959.2
    Conserved Domains (1) summary
    PHA03307
    Location:240 → 671
    PHA03307; transcriptional regulator ICP4; Provisional

RNA

  1. XR_003949229.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YE4.1 GenPept UniProtKB/Swiss-Prot:Q80YE4

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