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Pzp PZP, alpha-2-macroglobulin like [ Mus musculus (house mouse) ]

Gene ID: 11287, updated on 27-Feb-2024

Summary

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Official Symbol
Pzpprovided by MGI
Official Full Name
PZP, alpha-2-macroglobulin likeprovided by MGI
Primary source
MGI:MGI:87854
See related
Ensembl:ENSMUSG00000030359 AllianceGenome:MGI:87854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A1m; A2m; MAM
Summary
Enables endopeptidase inhibitor activity. Acts upstream of or within embryo implantation. Located in collagen-containing extracellular matrix. Is expressed in liver and liver lobe. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
6 F3; 6 63.02 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128460530..128503683, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128483567..128526720, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_17445 Neighboring gene STARR-positive B cell enhancer ABC_E6493 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene mitochondrial intermembrane space import and assembly protein 40 pseudogene Neighboring gene predicted pseudogene 8724

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime. Jiang X, et al. Front Physiol, 2022. PMID 36051914, Free PMC Article
  2. Endometrial alpha-2 macroglobulin; localization by in situ hybridization and effect on mouse embryo development in vitro. Sayegh RA, et al. J Clin Endocrinol Metab, 1997 Dec. PMID 9398738
  3. The identification of alpha-2-macroglobulin in the mouse. Greene ND, et al. Biochim Biophys Acta, 1971 Jun 29. PMID 5559967
  4. Inhibition of nerve growth factor-stimulated neurite outgrowth by methylamine-modified alpha 2-macroglobulin. Koo PH, et al. J Neurosci Res, 1992 Apr. PMID 1374478
  5. Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. Krause K, et al. Front Microbiol, 2019. PMID 30814992, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables brain-derived neurotrophic factor binding ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo implantation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pregnancy zone protein
Names
alpha 1 macroglobulin
alpha-2-M
alpha-2-macroglobulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007376.4 → NP_031402.3  pregnancy zone protein precursor

    See identical proteins and their annotated locations for NP_031402.3

    Status: VALIDATED

    Source sequence(s)
    AC123060
    Consensus CDS
    CCDS39650.1
    UniProtKB/Swiss-Prot
    E9QPW0, Q60628, Q61838, Q6PEM2
    Related
    ENSMUSP00000107760.2, ENSMUST00000112132.8
    Conserved Domains (6) summary
    cd02897
    Location:970 → 1282
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:750 → 840
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:127 → 219
    A2M_N; MG2 domain
    pfam07677
    Location:1395 → 1482
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1022 → 1284
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:460 → 605
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128460530..128503683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61838.3 GenPept UniProtKB/Swiss-Prot:Q61838

Gene LinkOut

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