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CYP4F8 cytochrome P450 family 4 subfamily F member 8 [ Homo sapiens (human) ]

Gene ID: 11283, updated on 3-Apr-2024

Summary

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Official Symbol
CYP4F8provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 8provided by HGNC
Primary source
HGNC:HGNC:2648
See related
Ensembl:ENSG00000186526 MIM:611545; AllianceGenome:HGNC:2648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPF8; CYPIVF8
Summary
This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 2.3), skin (RPKM 0.2) and 2 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p13.12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15615218..15630639)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15740324..15755884)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15726029..15741449)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904644 Neighboring gene ribosomal protein L23a pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10286 Neighboring gene cytochrome P450 family 4 subfamily F member 3 Neighboring gene cytochrome P450 family 4 subfamily F member 10, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions. Stark K, et al. Arch Biochem Biophys, 2003 Jan 1. PMID 12464258
  2. Oxidation of prostaglandin H(2) and prostaglandin H(2) analogues by human cytochromes P450: analysis of omega-side chain hydroxy metabolites and four steroisomers of 5-hydroxyprostaglandin I(1) by mass spectrometry. Oliw EH, et al. Biochem Pharmacol, 2001 Aug 15. PMID 11448449
  3. Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. Bylund J, et al. J Biol Chem, 2000 Jul 21. PMID 10791960
  4. New Proluciferin Substrates for Human CYP4 Family Enzymes. Liu J, et al. Appl Biochem Biotechnol, 2021 Jan. PMID 32869209
  5. Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. Stark K, et al. Arch Biochem Biophys, 2005 Sep 15. PMID 16112640

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New Proluciferin Substrates for Human CYP4 Family Enzymes.
    Title: New Proluciferin Substrates for Human CYP4 Family Enzymes.
  2. The PLA2G7, HPGD, EPHX2, and CYP4F8 genes are highly expressed in prostate cancer.
    Title: Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
  4. PGH synthase-2, CYP4F8, and PGE synthase-1 likely forms 19-hydroxy-PGE compounds in seminal vesicles and vas deferens
    Title: On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens.
  5. We conclude that CYP4F8 and CYP4F12 catalyze epoxidation of 22:6n-3 and 22:5n-3, and CYP4F8 omega3-hydroxylation of 22:5n-6.
    Title: Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.
  6. expression analysis of CYP4F8 shows that high levels are found in epithelial linings and epidermis of psoriatic lesions
    Title: Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alkane 1-monooxygenase activity TAS
Traceable Author Statement
more info
 PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in icosanoid metabolic process TAS
Traceable Author Statement
more info
  
involved_in prostaglandin metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cytochrome P450 4F8
Names
cytochrome P450, family 4, subfamily F, polypeptide 8
cytochrome P450, subfamily IVF, polypeptide 8
flavoprotein-linked monooxygenase
microsomal monooxygenase
NP_009184.1
XP_024307109.1
XP_054175663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008068.1 RefSeqGene

    Range
    5001..20422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007253.4 → NP_009184.1  cytochrome P450 4F8

    See identical proteins and their annotated locations for NP_009184.1

    Status: REVIEWED

    Source sequence(s)
    AD000685, AF133298, AI401776, DA871128, DA877298, DB329701
    Consensus CDS
    CCDS74303.1
    UniProtKB/Swiss-Prot
    P98187
    UniProtKB/TrEMBL
    B2RBJ0
    Related
    ENSP00000477567.1, ENST00000612078.5
    Conserved Domains (1) summary
    pfam00067
    Location:52 → 504
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    15615218..15630639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451341.2 → XP_024307109.1  cytochrome P450 4F8 isoform X1

    UniProtKB/TrEMBL
    B2RBJ0
    Related
    ENST00000441682.6
    Conserved Domains (1) summary
    pfam00067
    Location:52 → 417
    p450; Cytochrome P450

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    15740324..15755884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319688.1 → XP_054175663.1  cytochrome P450 4F8 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98187.1 GenPept UniProtKB/Swiss-Prot:P98187

Gene LinkOut

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Chemical Information
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Research Materials
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