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DTD2 D-aminoacyl-tRNA deacylase 2 [ Homo sapiens (human) ]

Gene ID: 112487, updated on 5-Mar-2024

Summary

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Official Symbol
DTD2provided by HGNC
Official Full Name
D-aminoacyl-tRNA deacylase 2provided by HGNC
Primary source
HGNC:HGNC:20277
See related
Ensembl:ENSG00000129480 AllianceGenome:HGNC:20277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATD; C14orf126
Summary
Enables Ala-tRNA(Thr) hydrolase activity. Involved in aminoacyl-tRNA metabolism involved in translational fidelity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 6.7), brain (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

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See DTD2 in Genome Data Viewer
Location:
14q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (31446036..31457506, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (25643623..25655096, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31915242..31926712, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 5A Neighboring gene uncharacterized LOC124903438 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8233 Neighboring gene HEATR5A divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31925731-31926316 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31926317-31926902 Neighboring gene ribosomal protein L9 pseudogene 4 Neighboring gene G protein-coupled receptor 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia. Kuncha SK, et al. Nat Commun, 2018 Feb 6. PMID 29410408, Free PMC Article
  2. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  5. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9912, FLJ51408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Ala-tRNA(Thr) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
D-aminoacyl-tRNA deacylase 2
Names
D-tyrosyl-tRNA deacylase 2 (putative)
D-tyrosyl-tRNA(Tyr) deacylase 2
L-alanyl-tRNA deacylase
animalia-specifc tRNA deacylase
animalia-specific tRNA deacylase
probable D-tyrosyl-tRNA(Tyr) deacylase 2
putative D-tyrosyl-tRNA deacylase 2
putative D-tyrosyl-tRNA(Tyr) deacylase 2
NP_542395.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080664.3 → NP_542395.1  D-aminoacyl-tRNA deacylase 2

    See identical proteins and their annotated locations for NP_542395.1

    Status: VALIDATED

    Source sequence(s)
    AK055367, AL139353, AL163973, BI553940, BU675173
    Consensus CDS
    CCDS9643.1
    UniProtKB/Swiss-Prot
    D3DS87, Q96FN9
    Related
    ENSP00000312224.4, ENST00000310850.9
    Conserved Domains (1) summary
    pfam02580
    Location:11 → 167
    Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    31446036..31457506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    25643623..25655096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FN9.1 GenPept UniProtKB/Swiss-Prot:Q96FN9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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