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GPR176 G protein-coupled receptor 176 [ Homo sapiens (human) ]

Gene ID: 11245, updated on 5-Mar-2024

Summary

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Official Symbol
GPR176provided by HGNC
Official Full Name
G protein-coupled receptor 176provided by HGNC
Primary source
HGNC:HGNC:32370
See related
Ensembl:ENSG00000166073 MIM:612183; AllianceGenome:HGNC:32370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB-954
Summary
Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]
Expression
Broad expression in brain (RPKM 2.2), testis (RPKM 1.7) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
15q14-q15.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (39799008..39920266, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (37604203..37725586, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40091209..40212467, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370785 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr15:39958804-39959320 Neighboring gene Sharpr-MPRA regulatory region 4200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6312 Neighboring gene uncharacterized LOC105370941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9217 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40176182-40176852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40176853-40177522 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40177802-40178334 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:40179399-40179929 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40178335-40178866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40186807-40187332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40200676-40201176 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40209802-40209908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40211506-40212311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6314 Neighboring gene GPR176 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9219 Neighboring gene small nucleolar RNA U13 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells. Zhang Y, et al. Sci Rep, 2023 Jun 8. PMID 37291181, Free PMC Article
  2. cDNA cloning of a putative G protein-coupled receptor from brain. Hata S, et al. Biochim Biophys Acta, 1995 Mar 14. PMID 7893747
  3. G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review]. Goto K, et al. Endocr J, 2017 Jun 29. PMID 28502923
  4. GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer. Tang J, et al. Adv Sci (Weinh), 2023 Apr. PMID 36905238, Free PMC Article
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer.
    Title: The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer.
  2. High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.
    Title: High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.
  3. GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
    Title: GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
  4. Data suggest that Gpr176 is an SCN-(suprachiasmatic nucleus-)enriched orphan GPCR (G-protein-coupled receptor) that sets the pace of circadian behavior. [REVIEW]
    Title: G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in circadian behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 176
Names
probable G-protein coupled receptor 176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271854.2 → NP_001258783.1  G-protein coupled receptor 176 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC012377, AC023908
    Consensus CDS
    CCDS61589.1
    UniProtKB/Swiss-Prot
    Q14439
    Related
    ENSP00000299092.3, ENST00000299092.4
    Conserved Domains (1) summary
    pfam00001
    Location:78 → 318
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_001271855.2 → NP_001258784.1  G-protein coupled receptor 176 isoform 3

    See identical proteins and their annotated locations for NP_001258784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC023908
    Consensus CDS
    CCDS61588.1
    UniProtKB/Swiss-Prot
    Q14439
    Related
    ENSP00000439361.1, ENST00000543580.7
    Conserved Domains (1) summary
    pfam00001
    Location:13 → 274
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_007223.3 → NP_009154.1  G-protein coupled receptor 176 isoform 1

    See identical proteins and their annotated locations for NP_009154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC012377, AC023908
    Consensus CDS
    CCDS10051.1
    UniProtKB/Swiss-Prot
    B4DZ23, H9NIL9, J3KNC6, Q14439, Q6NXF6
    Related
    ENSP00000453076.1, ENST00000561100.2
    Conserved Domains (1) summary
    pfam00001
    Location:58 → 319
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    39799008..39920266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021878.3 → XP_016877367.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:1 → 14
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_017021873.3 → XP_016877362.1  G-protein coupled receptor 176 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:26 → 287
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. XM_011521167.4 → XP_011519469.1  G-protein coupled receptor 176 isoform X1

    See identical proteins and their annotated locations for XP_011519469.1

    Conserved Domains (1) summary
    pfam00001
    Location:26 → 287
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  4. XM_017021874.3 → XP_016877363.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:1 → 14
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_024449835.2 → XP_024305603.1  G-protein coupled receptor 176 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:1 → 14
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 168
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    37604203..37725586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377224.1 → XP_054233199.1  G-protein coupled receptor 176 isoform X2

  2. XM_054377221.1 → XP_054233196.1  G-protein coupled receptor 176 isoform X1

  3. XM_054377220.1 → XP_054233195.1  G-protein coupled receptor 176 isoform X1

  4. XM_054377222.1 → XP_054233197.1  G-protein coupled receptor 176 isoform X2

  5. XM_054377223.1 → XP_054233198.1  G-protein coupled receptor 176 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14439.1 GenPept UniProtKB/Swiss-Prot:Q14439

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