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DUSP10 dual specificity phosphatase 10 [ Homo sapiens (human) ]

Gene ID: 11221, updated on 11-Apr-2024

Summary

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Official Symbol
DUSP10provided by HGNC
Official Full Name
dual specificity phosphatase 10provided by HGNC
Primary source
HGNC:HGNC:3065
See related
Ensembl:ENSG00000143507 MIM:608867; AllianceGenome:HGNC:3065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKP5; MKP-5
Summary
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Broad expression in liver (RPKM 11.1), bone marrow (RPKM 10.7) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
1q41
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (221701424..221742089, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (220941255..220981921, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (221874766..221915431, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985462 Neighboring gene solute carrier family 35 member E3 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:221728686-221729186 Neighboring gene uncharacterized LOC105372937 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:221750608-221750764 Neighboring gene Sharpr-MPRA regulatory region 4850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2560 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:221887070-221888269 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:221888831-221889360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2562 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:221914501-221915138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2563 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:221915139-221915776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:221915777-221916414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2570 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:222009541-222009747 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:222012693-222013892 Neighboring gene long intergenic non-protein coding RNA 1655 Neighboring gene uncharacterized LOC124904517 Neighboring gene RNA, U6 small nuclear 403, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:222029846-222030731 Neighboring gene long intergenic non-protein coding RNA 2257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DUSP10 is a novel immune-related biomarker connected with survival and cellular proliferation in lower-grade glioma. Xiao F, et al. Aging (Albany NY), 2023 Jun 29. PMID 37387540, Free PMC Article
  2. The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis. Song Z, et al. Exp Cell Res, 2019 Sep 1. PMID 31202710
  3. DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling. Manley GCA, et al. J Virol, 2019 Jan 15. PMID 30333178, Free PMC Article
  4. Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population. Duan X, et al. Int J Clin Exp Pathol, 2015. PMID 25973098, Free PMC Article
  5. DUSP10 gene polymorphism and risk of colorectal cancer in the Han Chinese population. Zhang T, et al. Eur J Cancer Prev, 2014 May. PMID 23872954

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DUSP10 is a novel immune-related biomarker connected with survival and cellular proliferation in lower-grade glioma.
    Title: DUSP10 is a novel immune-related biomarker connected with survival and cellular proliferation in lower-grade glioma.
  2. MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma.
    Title: MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma.
  3. De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
    Title: De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
  4. An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.
    Title: An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.
  5. SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.
    Title: SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.
  6. Gene overexpression and knockdown demonstrated that MKP-5 could alleviate glucolipotoxicity-induced apoptosis via the endoplasmic reticulum (ER) stress and mitochondrial apoptosis pathways owing to the altered regulation of caspase family members and ER stress-related molecules. MKP-5 is a main mediator for glucolipotoxicity-induced islet cell dysfunction and apoptosis, with JNK and P38 as critical downstream pathways.
    Title: The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis.
  7. Study of genome-wide epigenetic changes in bronchial epithelial cells of asthmatic patients, following cells treatment with vitamin D3 and Poly (I:C)(a viral analogue) allows the identification of biologically plausible candidate genes for viral infections and asthma, such as DUSP10 and SLC44A1.
    Title: Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells.
  8. High DUSP10 expression is associated with pulmonary fibrosis.
    Title: Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis.
  9. Data found DUSP10 downregulated by rhinovirus (RV) infection. siRNA-mediated knockdown of DUSP10 identified a role for the protein in negatively regulating inflammatory cytokine production in response to IL-1beta alone and in combination with RV, without any effect on RV replication. This study identifies DUSP10 as an important regulator of airway inflammation in respiratory viral infection.
    Title: DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling.
  10. Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants
    Title: Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
EBI GWAS Catalog
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
EBI GWAS Catalog
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables JUN kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase p38 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of epithelium regeneration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of p38MAPK cascade NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of respiratory burst involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein phosphatase 10
Names
dual specificity phosphatase MKP-5
map kinase phosphatase 5
mitogen-activated protein kinase phosphatase 5
serine/threonine specific protein phosphatase
NP_009138.1
XP_016855636.1
XP_047298898.1
XP_047298904.1
XP_054189977.1
XP_054189978.1
XP_054189979.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007207.6 → NP_009138.1  dual specificity protein phosphatase 10

    See identical proteins and their annotated locations for NP_009138.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AI261880, BC031405, BC063826, BG720911
    Consensus CDS
    CCDS1528.1
    UniProtKB/Swiss-Prot
    D3DTB4, Q6GSI4, Q9H9Z5, Q9Y6W6
    UniProtKB/TrEMBL
    Q6IAR2
    Related
    ENSP00000355866.3, ENST00000366899.4
    Conserved Domains (2) summary
    cd00127
    Location:321 → 459
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:149 → 284
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RNA

  1. NR_111939.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons, and contains an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI261880, BC020608, BC063826
    Related
    ENST00000468085.5

  2. NR_111940.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AI261880, BC031405, BC063826, BG720911

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    221701424..221742089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442948.1 → XP_047298904.1  dual specificity protein phosphatase 10 isoform X3

  2. XM_047442942.1 → XP_047298898.1  dual specificity protein phosphatase 10 isoform X1

  3. XM_017000147.3 → XP_016855636.1  dual specificity protein phosphatase 10 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    220941255..220981921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334004.1 → XP_054189979.1  dual specificity protein phosphatase 10 isoform X3

  2. XM_054334002.1 → XP_054189977.1  dual specificity protein phosphatase 10 isoform X1

  3. XM_054334003.1 → XP_054189978.1  dual specificity protein phosphatase 10 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144728.2: Suppressed sequence

    Description
    NM_144728.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

  2. NM_144729.2: Suppressed sequence

    Description
    NM_144729.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6W6.1 GenPept UniProtKB/Swiss-Prot:Q9Y6W6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
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