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ZNF277 zinc finger protein 277 [ Homo sapiens (human) ]

Gene ID: 11179, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF277provided by HGNC
Official Full Name
zinc finger protein 277provided by HGNC
Primary source
HGNC:HGNC:13070
See related
Ensembl:ENSG00000198839 MIM:605465; AllianceGenome:HGNC:13070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRIF4; ZNF277P
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and metal ion binding activity. Predicted to act upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Although this gene is named as a pseudogene, it is not yet established that the truncated protein lost function (PubMed 16395595). The NCBI RefSeq Project therefore continues to treat this as a protein coding gene. [11 Apr 2007]
Expression
Ubiquitous expression in thyroid (RPKM 9.6), urinary bladder (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7q31.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (112206695..112343934)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (113525002..113662218)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (111846750..111983989)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:111602884-111603668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:111603669-111604451 Neighboring gene RNA, 5S ribosomal pseudogene 237 Neighboring gene ribosomal protein L7a pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26509 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:111767901-111768536 Neighboring gene NANOG hESC enhancer GRCh37_chr7:111802020-111802560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26510 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:111892650-111893231 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:111905044-111905648 Neighboring gene RN7SK pseudogene 187 Neighboring gene ZNF277 antisense RNA 1 Neighboring gene uncharacterized LOC105375456 Neighboring gene MT-ND6 pseudogene 24 Neighboring gene MT-ND5 pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment. Ceroni F, et al. Eur J Hum Genet, 2014 Oct. PMID 24518835, Free PMC Article
  2. Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms. Liang H, et al. Cancer Genet Cytogenet, 2005 Oct 15. PMID 16213364
  3. Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. Liang H, et al. Genomics, 2000 Jun 1. PMID 10860669
  4. The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction. Dionne KL, et al. J Biol Chem, 2019 Feb 8. PMID 30530495, Free PMC Article
  5. Human-specific nonsense mutations identified by genome sequence comparisons. Hahn Y, et al. Hum Genet, 2006 Mar. PMID 16395595

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF277 and PRMT3 compete for uS5 binding, because overexpression of PRMT3 inhibited the formation of the ZNF277-uS5 complex, whereas depletion of cellular ZNF277 resulted in increased levels of uS5-PRMT3.
    Title: The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction.
  2. ZNF277 microdeletions might contribute to the risk of language impairments
    Title: Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 277 (ZNF277) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 277
Names
nuclear receptor-interacting factor 4
zinc finger protein (C2H2 type) 277
zinc finger protein 277 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041797.1 RefSeqGene

    Range
    5108..142347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021994.3 → NP_068834.2  zinc finger protein 277

    See identical proteins and their annotated locations for NP_068834.2

    Status: VALIDATED

    Source sequence(s)
    AF209198, BG924796, DA285525, DB543718
    Consensus CDS
    CCDS5755.2
    UniProtKB/Swiss-Prot
    Q75MZ2, Q75MZ3, Q8WY14, Q9NRM2
    UniProtKB/TrEMBL
    A4D0S7
    Related
    ENSP00000354501.3, ENST00000361822.8
    Conserved Domains (2) summary
    sd00020
    Location:226 → 248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:175 → 262
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    112206695..112343934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515768.4 → XP_011514070.1  zinc finger protein 277 isoform X1

    See identical proteins and their annotated locations for XP_011514070.1

    UniProtKB/TrEMBL
    A4D0S7
    Conserved Domains (2) summary
    sd00020
    Location:148 → 170
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:97 → 184
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)

  2. XM_017011720.3 → XP_016867209.1  zinc finger protein 277 isoform X2

    Conserved Domains (2) summary
    sd00020
    Location:108 → 130
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:57 → 144
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    113525002..113662218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357167.1 → XP_054213142.1  zinc finger protein 277 isoform X1

  2. XM_054357168.1 → XP_054213143.1  zinc finger protein 277 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRM2.2 GenPept UniProtKB/Swiss-Prot:Q9NRM2

Gene LinkOut

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