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Prn prion protein readthrough transcript [ Mus musculus (house mouse) ]

Gene ID: 111368, updated on 8-Feb-2024

Summary

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Official Symbol
Prnprovided by MGI
Official Full Name
prion protein readthrough transcriptprovided by MGI
Primary source
MGI:MGI:97767
See related
Ensembl:ENSMUSG00000098754 AllianceGenome:MGI:97767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm28045; Gm44637; Prnp-Prnd
Summary
This locus represents naturally occurring readthrough transcription between the neighboring Prnp (major prion protein) and Prnd (prion-like protein doppel) genes on chromosome 2. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is distinct due to the presence of an in-frame, upstream AUG compared to the downstream gene. [provided by RefSeq, May 2013]
Expression
Broad expression in testis adult (RPKM 22.5), limb E14.5 (RPKM 10.9) and 17 other tissues See more
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Genomic context

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Location:
2 F2; 2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131751848..131798051)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131909928..131956131)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endogenous retroviral sequence 3 Neighboring gene laminin receptor 1 (ribosomal protein SA), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_05721 Neighboring gene STARR-seq mESC enhancer starr_05722 Neighboring gene prion protein Neighboring gene STARR-seq mESC enhancer starr_05723 Neighboring gene prion like protein doppel Neighboring gene Ras association (RalGDS/AF-6) domain family member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:131844916-131845217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131846634-131846817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131855025-131855212 Neighboring gene STARR-positive B cell enhancer ABC_E9533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131861333-131861539 Neighboring gene predicted gene, 31179 Neighboring gene STARR-positive B cell enhancer ABC_E5986

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prion proteins and ECTO-NOX proteins exhibit similar oscillating redox activities. Kim C, et al. Biochem Biophys Res Commun, 2004 Mar 19. PMID 14985132
  2. Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein. Telling GC, et al. Proc Natl Acad Sci U S A, 1994 Oct 11. PMID 7937921, Free PMC Article
  3. Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Hsiao KK, et al. Proc Natl Acad Sci U S A, 1994 Sep 13. PMID 7916462, Free PMC Article
  4. Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice. Hunter N, et al. J Gen Virol, 1992 Oct. PMID 1357080
  5. Characterisation of two promoters for prion protein (PrP) gene expression in neuronal cells. Baybutt H, et al. Gene, 1997 Jan 3. PMID 9016962

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein
    Title: Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Readthrough Prn

Included genes: Prnp, Prnd

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prion protein gene complex
Names
Prnp-Prnd readthrough

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278258.1 → NP_001265187.1  prion protein gene complex

    See identical proteins and their annotated locations for NP_001265187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL833794
    UniProtKB/TrEMBL
    A0A075B668, A7U7N0, C7E3P5
    Related
    ENSMUSP00000122345.3, ENSMUST00000136783.2
    Conserved Domains (2) summary
    pfam00377
    Location:82 → 196
    Prion; Prion/Doppel alpha-helical domain
    pfam11466
    Location:19 → 48
    Doppel; Prion-like protein Doppel

  2. NM_001278259.1 → NP_001265188.1  prion protein gene complex

    See identical proteins and their annotated locations for NP_001265188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL833794
    UniProtKB/TrEMBL
    A0A075B668, A7U7N0, C7E3P5
    Related
    ENSMUSP00000116195.3, ENSMUST00000124100.8
    Conserved Domains (2) summary
    pfam00377
    Location:82 → 196
    Prion; Prion/Doppel alpha-helical domain
    pfam11466
    Location:19 → 48
    Doppel; Prion-like protein Doppel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    131751848..131798051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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