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RPP14 ribonuclease P/MRP subunit p14 [ Homo sapiens (human) ]

Gene ID: 11102, updated on 5-Mar-2024

Summary

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Official Symbol
RPP14provided by HGNC
Official Full Name
ribonuclease P/MRP subunit p14provided by HGNC
Primary source
HGNC:HGNC:30327
See related
Ensembl:ENSG00000163684 MIM:606112; AllianceGenome:HGNC:30327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P14
Summary
This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in thyroid (RPKM 4.8), kidney (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

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See RPP14 in Genome Data Viewer
Location:
3p14.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (58306245..58320193)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (58346652..58360600)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58291972..58305920)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20005 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:58202830-58203333 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:58203334-58203836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:58222930-58223869 Neighboring gene abhydrolase domain containing 6, acylglycerol lipase Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:58276464-58277147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:58298051-58298552 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:58307710-58308471 Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14488 Neighboring gene Sharpr-MPRA regulatory region 6112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20010 Neighboring gene uncharacterized LOC105377106 Neighboring gene PX domain containing serine/threonine kinase like Neighboring gene MPRA-validated peak4672 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:58363583-58363810 Neighboring gene WDR53 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Death of a dogma: eukaryotic mRNAs can code for more than one protein. Mouilleron H, et al. Nucleic Acids Res, 2016 Jan 8. PMID 26578573, Free PMC Article
  2. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. Jiang T, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11929972, Free PMC Article
  3. An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing. Autio KJ, et al. FASEB J, 2008 Feb. PMID 17898086
  4. Protein-protein interactions with subunits of human nuclear RNase P. Jiang T, et al. Proc Natl Acad Sci U S A, 2001 Jan 30. PMID 11158571, Free PMC Article
  5. Protein-RNA interactions in the subunits of human nuclear RNase P. Jiang T, et al. RNA, 2001 Jul. PMID 11455963, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity.
    Title: A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31508

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonuclease P RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p14
Names
ribonuclease P/MRP 14kDa subunit
NP_001092253.1
NP_008973.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098783.3 → NP_001092253.1  ribonuclease P protein subunit p14

    See identical proteins and their annotated locations for NP_001092253.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC098479, CN354601, DC360931
    Consensus CDS
    CCDS2888.1
    UniProtKB/Swiss-Prot
    O95059, Q53X97
    Related
    ENSP00000412894.2, ENST00000445193.7
    Conserved Domains (1) summary
    pfam01900
    Location:35 → 108
    RNase_P_Rpp14; Rpp14/Pop5 family

  2. NM_007042.6 → NP_008973.1  ribonuclease P protein subunit p14

    See identical proteins and their annotated locations for NP_008973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC098479, BC002441, DC360931
    Consensus CDS
    CCDS2888.1
    UniProtKB/Swiss-Prot
    O95059, Q53X97
    Related
    ENSP00000295959.5, ENST00000295959.10
    Conserved Domains (1) summary
    pfam01900
    Location:35 → 108
    RNase_P_Rpp14; Rpp14/Pop5 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    58306245..58320193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    58346652..58360600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_049755.1: Suppressed sequence

    Description
    NR_049755.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.

  2. NR_049756.1: Suppressed sequence

    Description
    NR_049756.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.

  3. NR_049757.1: Suppressed sequence

    Description
    NR_049757.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.

  4. NR_049758.1: Suppressed sequence

    Description
    NR_049758.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95059.3 GenPept UniProtKB/Swiss-Prot:O95059

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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