Nudt19 nudix hydrolase 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt19provided by MGI
Official Full Name: nudix hydrolase 19provided by MGI
Primary source: MGI:MGI:94203
See related: Ensembl:ENSMUSG00000034875 AllianceGenome:MGI:94203
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D7Rp2; RP2-r; RP2-s; D7Rp2e; D7Rp2-r; D7Rp2-s
Summary: Enables magnesium ion binding activity. Involved in purine nucleoside bisphosphate metabolic process. Located in mitochondrion. Is expressed in several structures, including Harderian gland; alimentary system; liver; male reproductive gland or organ; and metanephros. Orthologous to human NUDT19 (nudix hydrolase 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 83.0), adrenal adult (RPKM 55.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 21.37 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (35246610..35258345, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (35547185..35558643, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes.
Title: Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes.
The isolation and characterization of D7RP2e in mouse kidney peroxisomes is reported.
Title: Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nudt19 (e-PCR), detects polymorphism
- UniSTS:508536

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in butyryl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in coenzyme A catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malonyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in medium-chain fatty-acyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in propionyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in succinyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl-coenzyme A diphosphatase NUDT19

Names: RP2p; androgen regulated gene RP2; androgen-regulated protein RP2; nucleoside diphosphate-linked moiety X motif 19, mitochondrial; nudix (nucleoside diphosphate linked moiety X)-type motif 19; nudix motif 19; renal CoA diphosphohydrolase; testosterone-regulated RP2 protein

NP_149071.2

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.