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Hspa13 heat shock protein 70 family, member 13 [ Mus musculus (house mouse) ]

Gene ID: 110920, updated on 21-Apr-2024

Summary

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Official Symbol
Hspa13provided by MGI
Official Full Name
heat shock protein 70 family, member 13provided by MGI
Primary source
MGI:MGI:1309463
See related
Ensembl:ENSMUSG00000032932 AllianceGenome:MGI:1309463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stch; 1600002I10Rik; B230217N24Rik
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human HSPA13 (heat shock protein family A (Hsp70) member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 10.3), CNS E18 (RPKM 6.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C3.1; 16 43.36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (75552078..75564575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (75755190..75767276, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41474 Neighboring gene predicted gene, 30162 Neighboring gene predicted gene 15553 Neighboring gene STARR-positive B cell enhancer ABC_E1494 Neighboring gene STARR-positive B cell enhancer ABC_E8914 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene SAM domain, SH3 domain and nuclear localization signals, 1 Neighboring gene STARR-positive B cell enhancer ABC_E8643 Neighboring gene STARR-positive B cell enhancer ABC_E9430 Neighboring gene STARR-positive B cell enhancer mm9_chr16:75908045-75908345 Neighboring gene STARR-positive B cell enhancer mm9_chr16:75909418-75909719

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. Grizenkova J, et al. Proc Natl Acad Sci U S A, 2012 Aug 21. PMID 22869728, Free PMC Article
  2. Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation. Zhai B, et al. Mol Immunol, 2022 Jan. PMID 34837777
  3. Genetic control of experience-dependent plasticity in the visual cortex. Heimel JA, et al. Genes Brain Behav, 2008 Nov. PMID 18700840
  4. Stch maps to mouse chromosome 16, extending the conserved synteny with human chromosome 21. Reeves RH, et al. Genomics, 1998 Apr 1. PMID 9570963
  5. Hspa13 Promotes Plasma Cell Production and Antibody Secretion. He Y, et al. Front Immunol, 2020. PMID 32547538, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-cell atlas of splenocytes reveals a critical role of a novel plasma cellspecific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.
    Title: Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.
  2. Hspa13 Promotes Plasma Cell Production and Antibody Secretion.
    Title: Hspa13 Promotes Plasma Cell Production and Antibody Secretion.
  3. Hspa13 (Stch) gene has a role in prion disease incubation time in mice
    Title: Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heat shock 70 kDa protein 13
Names
heat shock protein 70kDa family, member 13
microsomal stress-70 protein ATPase core
stress 70 protein chaperone, microsome-associated, 60kD human homolog
stress 70 protein chaperone, microsome-associated, human homolog
stress-70 protein chaperone microsome-associated 60 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030201.3 → NP_084477.1  heat shock 70 kDa protein 13 precursor

    See identical proteins and their annotated locations for NP_084477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    BC085181, BY133105, CO043820
    Consensus CDS
    CCDS28273.1
    UniProtKB/Swiss-Prot
    Q3TII6, Q8BM72, Q9D1X5
    Related
    ENSMUSP00000048817.9, ENSMUST00000046283.16
    Conserved Domains (2) summary
    cd10237
    Location:12 → 463
    HSPA13-like_NBD; Nucleotide-binding domain of human HSPA13 and similar proteins
    PRK13930
    Location:32 → 442
    PRK13930; rod shape-determining protein MreB; Provisional

RNA

  1. NR_027492.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK030553, BC085181, BY133105, CO043820

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    75552078..75564575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522849.4 → XP_006522912.1  heat shock 70 kDa protein 13 isoform X1

    See identical proteins and their annotated locations for XP_006522912.1

    UniProtKB/TrEMBL
    D3Z0Y0
    Related
    ENSMUSP00000109882.2, ENSMUST00000114244.2
    Conserved Domains (1) summary
    cl17037
    Location:12 → 259
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BM72.1 GenPept UniProtKB/Swiss-Prot:Q8BM72

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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