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Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 [ Mus musculus (house mouse) ]

Gene ID: 110877, updated on 5-Mar-2024

Summary

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Official Symbol
Slc18a1provided by MGI
Official Full Name
solute carrier family 18 (vesicular monoamine), member 1provided by MGI
Primary source
MGI:MGI:106684
See related
Ensembl:ENSMUSG00000036330 AllianceGenome:MGI:106684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vat1; Vmat1; 4832416I10Rik
Summary
Predicted to enable enzyme binding activity and serotonin:sodium symporter activity. Predicted to be involved in aminergic neurotransmitter loading into synaptic vesicle; regulation of ion transport; and serotonin uptake. Predicted to act upstream of or within neurotransmitter transport. Located in synapse. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 38.4), adrenal adult (RPKM 4.8) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Slc18a1 in Genome Data Viewer
Location:
8 B3.3; 8 33.88 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (69490360..69547951, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69037708..69089238, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32997 Neighboring gene predicted gene, 33103 Neighboring gene predicted gene, 33052 Neighboring gene STARR-seq mESC enhancer starr_21713 Neighboring gene STARR-seq mESC enhancer starr_21714 Neighboring gene STARR-positive B cell enhancer ABC_E8237 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit B2 Neighboring gene STARR-positive B cell enhancer ABC_E8238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71645510-71645697 Neighboring gene leucine zipper, putative tumor suppressor 1 Neighboring gene predicted gene, 39187 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71700363-71700564 Neighboring gene STARR-positive B cell enhancer ABC_E6640 Neighboring gene STARR-positive B cell enhancer ABC_E3775 Neighboring gene predicted gene, 39188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling. Lohoff FW, et al. Brain Res, 2019 Jun 1. PMID 30685272
  2. Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. Ashe KM, et al. Neuro Endocrinol Lett, 2011. PMID 21712771
  3. Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety. Sato DX, et al. iScience, 2022 Aug 19. PMID 35992083, Free PMC Article
  4. VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination. Multani PK, et al. Neuroscience, 2013 Mar 1. PMID 23201251, Free PMC Article
  5. Chromosomal localization of the human vesicular amine transporter genes. Peter D, et al. Genomics, 1993 Dec. PMID 7905859

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling.
    Title: Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling.
  2. Study shows that VMAT1 is expressed in mouse brain and plays a key role in survival of hippocampal neurons
    Title: VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination.
  3. a functional VMAT-1 mRNA coding sequence is expressed in mouse brain and suggest processing of VMAT-1 protein differs in mouse adrenal and brain
    Title: Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (5)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC28683, MGC37299

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables monoamine:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoamine:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables serotonin:sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin:sodium:chloride symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dopamine uptake ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of serotonin uptake ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in serotonin uptake IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serotonin uptake ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chromaffin granule amine transporter
Names
solute carrier family 18 member 1
vesicular amine transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153054.2 → NP_694694.1  chromaffin granule amine transporter

    See identical proteins and their annotated locations for NP_694694.1

    Status: VALIDATED

    Source sequence(s)
    AC114995, AK076433, CN663918
    Consensus CDS
    CCDS22344.1
    UniProtKB/Swiss-Prot
    Q8R090
    UniProtKB/TrEMBL
    Q32XG7
    Related
    ENSMUSP00000046924.7, ENSMUST00000037478.13
    Conserved Domains (1) summary
    cd17384
    Location:127 → 475
    MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    69490360..69547951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509534.5 → XP_006509597.1  chromaffin granule amine transporter isoform X1

    See identical proteins and their annotated locations for XP_006509597.1

    UniProtKB/Swiss-Prot
    Q8R090
    UniProtKB/TrEMBL
    Q32XG7
    Conserved Domains (1) summary
    cd17384
    Location:127 → 475
    MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily

  2. XM_011242262.4 → XP_011240564.1  chromaffin granule amine transporter isoform X3

    Conserved Domains (1) summary
    cd17384
    Location:34 → 424
    MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily

  3. XM_017312522.3 → XP_017168011.1  chromaffin granule amine transporter isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:127 → 435
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R090.1 GenPept UniProtKB/Swiss-Prot:Q8R090

Gene LinkOut

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