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DIDO1 death inducer-obliterator 1 [ Homo sapiens (human) ]

Gene ID: 11083, updated on 7-Apr-2024

Summary

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Official Symbol
DIDO1provided by HGNC
Official Full Name
death inducer-obliterator 1provided by HGNC
Primary source
HGNC:HGNC:2680
See related
Ensembl:ENSG00000101191 MIM:604140; AllianceGenome:HGNC:2680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8
Summary
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 4.7), spleen (RPKM 4.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See DIDO1 in Genome Data Viewer
Location:
20q13.33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62877743..62937904, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64677856..64738018, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61509095..61569256, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13411 Neighboring gene transcription factor like 5 Neighboring gene diphthamide biosynthesis 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13127 Neighboring gene uncharacterized LOC105372717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61492967-61493621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61506686-61507340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61507341-61507994 Neighboring gene Sharpr-MPRA regulatory region 11652 Neighboring gene MPRA-validated peak4302 silencer Neighboring gene ADP ribosylation factor 4 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61517086-61517616 Neighboring gene small nucleolar RNA, H/ACA box 117 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61531289-61532143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61553829-61554340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:61556733-61557346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:61557347-61557960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61558843-61559691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61569565-61570233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61583471-61584300 Neighboring gene GID complex subunit 8 homolog Neighboring gene solute carrier family 17 member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of DIDO1 in Progression of Esophageal Squamous Cell Carcinoma. Forghanifard MM, et al. J Gastrointest Cancer, 2020 Mar. PMID 30761474
  2. The expression of Death Inducer-Obliterator (DIDO) variants in Myeloproliferative Neoplasms. Berzoti-Coelho MG, et al. Blood Cells Mol Dis, 2016 Jul. PMID 27282563
  3. Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells. Wang Y, et al. Acta Pharmacol Sin, 2008 Mar. PMID 18298900
  4. Death inducer-obliterator 1 (Dido1) is a BMP target gene and promotes BMP-induced melanoma progression. Braig S, et al. Oncogene, 2013 Feb 14. PMID 22469980
  5. Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability. Trachana V, et al. Proc Natl Acad Sci U S A, 2007 Feb 20. PMID 17299043, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dido3 is an adaptor that controls SFPQ utilization in RNA splicing
    Title: Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing.
  2. CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability.
    Title: CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability.
  3. Role of DIDO1 in Progression of Esophageal Squamous Cell Carcinoma.
    Title: Role of DIDO1 in Progression of Esophageal Squamous Cell Carcinoma.
  4. Results identified a novel pH-dependent mechanism by which epigenetic reader, the PHD fingers of DIDO, recognize the histone mark H3K4me3. The pH-sensing ability might be necessary for normal biological processes and those characterized by altered cellular pH.
    Title: A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
  5. evaluated the Death Inducer-Obliterator (DIDO) (variants DIDO 1, 2 and 3) levels in CML, PV, ET and PMF patients. Our data reported the DIDO 1, 2 and 3 differential expressions in Myeloproliferative Neoplasms.
    Title: The expression of Death Inducer-Obliterator (DIDO) variants in Myeloproliferative Neoplasms.
  6. Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells.
    Title: Death inducer-obliterator 1 (Dido1) is a BMP target gene and promotes BMP-induced melanoma progression.
  7. Data show that CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status.
    Title: CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression.
  8. Gambogic acid induces the apoptosis of Raji cells through DIO-1 upregulation, nuclear translocation, Bcl-xL downregulation and caspase 3 activation.
    Title: [Mechanism of gambogic acid-induced apoptosis in Raji cells].
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Gambogic acid induces DIDO1-mediated apoptosis in Jurkat T cells.
    Title: Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11265, KIAA0333, MGC16140, DKFZp434P1115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
death-inducer obliterator 1
Names
death-associated transcription factor 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029496.1 RefSeqGene

    Range
    16448..65210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193369.2 → NP_001180298.1  death-inducer obliterator 1 isoform c

    See identical proteins and their annotated locations for NP_001180298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a different segment for its 5' UTR, compared to variant 4. Variants 4 and 5 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AY481572, CK300739, DA506324
    Consensus CDS
    CCDS33506.1
    UniProtKB/Swiss-Prot
    A8MY65, B9EH82, E1P5I1, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q4VXV8, Q4VXV9, Q96D72, Q9BQW0, Q9BTC0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6
    Related
    ENSP00000378752.1, ENST00000395343.6
    Conserved Domains (4) summary
    smart00510
    Location:672 → 773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160 → 302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266 → 319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1057 → 1163
    SPOC; SPOC domain

  2. NM_001193370.2 → NP_001180299.1  death-inducer obliterator 1 isoform b

    See identical proteins and their annotated locations for NP_001180299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains a different 5' UTR segment and a different terminal exon, compared to variant 4. It encodes a protein (isoform b) that has a distinct and shorter C-terminus when it is compared to isoform c. Variants 3 and 6 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AL035669, AW206895, AY481571, DA506324
    Consensus CDS
    CCDS13508.2
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000378749.1, ENST00000395340.5
    Conserved Domains (4) summary
    smart00510
    Location:672 → 773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160 → 302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266 → 319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1057 → 1163
    SPOC; SPOC domain

  3. NM_022105.5 → NP_071388.2  death-inducer obliterator 1 isoform a

    See identical proteins and their annotated locations for NP_071388.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has a different segment and lacks most of the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a shorter and distinct C-terminus when it is compared to isoform c. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    BC004237, DB460917
    Consensus CDS
    CCDS13509.1
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000359397.4, ENST00000370371.8
    Conserved Domains (2) summary
    COG5034
    Location:160 → 302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266 → 319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3

  4. NM_033081.3 → NP_149072.2  death-inducer obliterator 1 isoform c

    See identical proteins and their annotated locations for NP_149072.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest protein (isoform c). Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AB002331, AY481572, CK300739, CN348578, CN370112, DA294135
    Consensus CDS
    CCDS33506.1
    UniProtKB/Swiss-Prot
    A8MY65, B9EH82, E1P5I1, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q4VXV8, Q4VXV9, Q96D72, Q9BQW0, Q9BTC0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6
    Related
    ENSP00000266070.4, ENST00000266070.8
    Conserved Domains (4) summary
    smart00510
    Location:672 → 773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160 → 302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266 → 319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1057 → 1163
    SPOC; SPOC domain

  5. NM_080796.4 → NP_542986.1  death-inducer obliterator 1 isoform a

    See identical proteins and their annotated locations for NP_542986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 5' UTR segment and lacks most of the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a shorter and distinct C-terminus when it is compared to isoform c. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    BC014489, DA506324
    Consensus CDS
    CCDS13509.1
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000346692.4, ENST00000354665.8
    Conserved Domains (2) summary
    COG5034
    Location:160 → 302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266 → 319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3

  6. NM_080797.4 → NP_542987.2  death-inducer obliterator 1 isoform b

    See identical proteins and their annotated locations for NP_542987.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different terminal exon, compared to variant 4. It encodes a protein (isoform b) that has a distinct and shorter C-terminus when it is compared to isoform c. Variants 3 and 6 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AL035669, AW206895, DA294135
    Consensus CDS
    CCDS13508.2
    UniProtKB/Swiss-Prot
    Q9BTC0
    Conserved Domains (4) summary
    smart00510
    Location:672 → 773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160 → 302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266 → 319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1057 → 1163
    SPOC; SPOC domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62877743..62937904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    64677856..64738018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152302.1: Suppressed sequence

    Description
    NM_152302.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BTC0.5 GenPept UniProtKB/Swiss-Prot:Q9BTC0

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