Cebpe CCAAT/enhancer binding protein epsilon [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cebpeprovided by MGI
Official Full Name: CCAAT/enhancer binding protein epsilonprovided by MGI
Primary source: MGI:MGI:103572
See related: Ensembl:ENSMUSG00000052435 AllianceGenome:MGI:103572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRP1; Gm294; C/EBPe; C/EBPepsilon
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including defense response to bacterium; macrophage differentiation; and phagocytosis. Predicted to be located in nucleus. Is expressed in bone marrow; liver; lung; and spleen. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 15.2), liver adult (RPKM 4.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.9 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54947823..54949604, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54710363..54712174, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we have identified a novel enhancer crucial for regulating expression of Cebpe and required for normal granulocytic differentiation
Title: Identification of a novel enhancer of CEBPE essential for granulocytic differentiation.
study suggests that the myeloid specific factor C/EBPepsilon is involved in systemic lipid metabolism and that silencing of C/EBPepsilon could decrease the development of atherosclerosis.
Title: Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice.
Data show that macrophages from bbee compared to single knockout mice revealed decreased expression of essential immune response-related genes and networks.
Title: In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.
in the absence of CCAAT enhancer binding protein epsilon (C/EBPepsilon), there is not only incomplete differentiation of granulocytes, but myelopoiesis is disrupted and neutrophils have abnormal chemotaxis
Title: C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx.
Lbr, under transcriptional regulation of C/EBPepsilon, is necessary for morphological but not necessarily functional granulocyte
Title: The lamin B receptor under transcriptional control of C/EBPepsilon is required for morphological but not functional maturation of neutrophils.
Phosphorylation of PML was required for stimulating C/EBP epsilon-dependent transcription and accelerating C/EBP epsilon-induced granulocytic differentiation.
Title: Phosphorylation of PML is essential for activation of C/EBP epsilon and PU.1 to accelerate granulocytic differentiation.
The type IV isoform of PML interacted with PU.1, promoted its association with p300, and then enhanced PU.1-induced transcription and granulocytic differentiation and PU.1 directly activates the transcription of the C/EBPepsilon gene.
Title: PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation.
in the later stages of myeloid development, MMP8 and other SGP genes are coordinately upregulated, and members of the C/EBP family, in particular C/EBPalpha and C/EBPepsilon, play specific and unique roles in upregulating their expression
Title: Human neutrophil collagenase expression is C/EBP-dependent during myeloid development.
C/EBPepsilon interacts with Rb and E2F1 during granulocytic differentiation
Title: C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.
Gfi-1 down-regulates C/EBPepsilon expression; increased expression of C/EBPepsilon as a consequence of loss of Gfi-1 function may be deleterious to the proliferation and survival of early myeloid cells
Title: Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cebpe (e-PCR), detects polymorphism
- UniSTS:141321

PMC24284P1 (e-PCR)
- UniSTS:272252

NoName (e-PCR)
- UniSTS:484815

RH94775 (e-PCR)
- UniSTS:120022

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in granulocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCAAT/enhancer-binding protein epsilon

Names: C/EBP-related protein 1; CCAAT/enhancer binding protein (C/EBP), epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207131.2 → NP_997014.1 CCAAT/enhancer-binding protein epsilon

See identical proteins and their annotated locations for NP_997014.1

Status: VALIDATED

Source sequence(s)

CT009512

Consensus CDS

CCDS27100.1

UniProtKB/Swiss-Prot

Q32MW9, Q6PZD9

UniProtKB/TrEMBL

Q32MW8

Related

ENSMUSP00000068927.7, ENSMUST00000064290.8

Conserved Domains (1) summary

cd14715
Location:202 → 262

bZIP_CEBPE; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein epsilon (CEBPE): a DNA-binding and dimerization domain