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Nr3c2 nuclear receptor subfamily 3, group C, member 2 [ Mus musculus (house mouse) ]

Gene ID: 110784, updated on 21-Apr-2024

Summary

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Official Symbol
Nr3c2provided by MGI
Official Full Name
nuclear receptor subfamily 3, group C, member 2provided by MGI
Primary source
MGI:MGI:99459
See related
Ensembl:ENSMUSG00000031618 AllianceGenome:MGI:99459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MR; Mlr
Summary
Enables steroid binding activity. Involved in regulation of postsynaptic membrane potential and regulation of synaptic vesicle exocytosis. Acts upstream of or within cellular sodium ion homeostasis and excretion. Located in GABA-ergic synapse. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system and genitourinary system. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 12.0), frontal lobe adult (RPKM 3.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C1; 8 36.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (77626422..77971641)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (76898083..77245012)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10649 Neighboring gene predicted gene, 57499 Neighboring gene STARR-seq mESC enhancer starr_21947 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 24838 Neighboring gene predicted gene, 23260 Neighboring gene Rho GTPase activating protein 10 Neighboring gene STARR-seq mESC enhancer starr_21951 Neighboring gene STARR-seq mESC enhancer starr_21952 Neighboring gene STARR-seq mESC enhancer starr_21953 Neighboring gene predicted gene 45407 Neighboring gene STARR-seq mESC enhancer starr_21954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:79946917-79947070 Neighboring gene RIKEN cDNA 0610038B21 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness. González-Mayoral A, et al. J Endocrinol, 2023 Aug 1. PMID 37195271
  2. Osteoblast MR deficiency protects against adverse ventricular remodeling after myocardial infarction. Wang YL, et al. J Mol Cell Cardiol, 2022 Jun. PMID 35314145
  3. Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular ageing. Ibarrola J, et al. Cardiovasc Res, 2023 Jan 18. PMID 35020830, Free PMC Article
  4. Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor. Lee JY, et al. Endocrinol Metab (Seoul), 2021 Aug. PMID 34325504, Free PMC Article
  5. Mineralocorticoid and Estrogen Receptors in Endothelial Cells Coordinately Regulate Microvascular Function in Obese Female Mice. Biwer LA, et al. Hypertension, 2021 Jun. PMID 33934622, Free PMC Article

See all (195) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression.
    Title: Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression.
  2. NR3C2 activates LCN2 transcription to promote endoplasmic reticulum stress and cell apoptosis in ischemic cerebral infarction.
    Title: NR3C2 activates LCN2 transcription to promote endoplasmic reticulum stress and cell apoptosis in ischemic cerebral infarction.
  3. Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice.
    Title: Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice.
  4. Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness.
    Title: Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness.
  5. Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss.
    Title: Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss.
  6. Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular ageing.
    Title: Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular ageing.
  7. miR-324-5p and miR-30c-2-3p Alter Renal Mineralocorticoid Receptor Signaling under Hypertonicity.
    Title: miR-324-5p and miR-30c-2-3p Alter Renal Mineralocorticoid Receptor Signaling under Hypertonicity.
  8. Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor.
    Title: Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor.
  9. Myeloid mineralocorticoid receptors contribute to skeletal muscle repair in muscular dystrophy and acute muscle injury.
    Title: Myeloid mineralocorticoid receptors contribute to skeletal muscle repair in muscular dystrophy and acute muscle injury.
  10. Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.
    Title: Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.
Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear steroid receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in angiotensin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to aldosterone ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular steroid hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of blood volume by renal aldosterone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of potassium:proton exchanging ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within renal sodium excretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mineralocorticoid receptor
Names
aldosterone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083906.3 → NP_001077375.1  mineralocorticoid receptor

    See identical proteins and their annotated locations for NP_001077375.1

    Status: VALIDATED

    Source sequence(s)
    AC116768, AC118019, AC119248
    Consensus CDS
    CCDS40393.1
    UniProtKB/Swiss-Prot
    Q8VII8, Q8VII9
    UniProtKB/TrEMBL
    A3KN90
    Related
    ENSMUSP00000105538.2, ENSMUST00000109912.8
    Conserved Domains (3) summary
    cd07075
    Location:733 → 980
    NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:599 → 673
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam05109
    Location:200 → 394
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. NM_001426575.1 → NP_001413504.1  mineralocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC116768, AC118019, AC119248
    UniProtKB/TrEMBL
    A3KN90

  3. NM_001426576.1 → NP_001413505.1  mineralocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC116768, AC118019, AC119248
    UniProtKB/TrEMBL
    A3KN90

  4. NM_001426577.1 → NP_001413506.1  mineralocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC116768, AC118019, AC119248
    UniProtKB/TrEMBL
    A3KN90

  5. NM_001426578.1 → NP_001413507.1  mineralocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC116768, AC118019, AC119248
    UniProtKB/TrEMBL
    A3KN90

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    77626422..77971641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153720.1 → XP_036009613.1  mineralocorticoid receptor isoform X2

    UniProtKB/TrEMBL
    D6RIL1
    Related
    ENSMUSP00000118222.2, ENSMUST00000148106.8
    Conserved Domains (2) summary
    cd07172
    Location:599 → 671
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam15921
    Location:112 → 308
    CCDC158; Coiled-coil domain-containing protein 158
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VII8.2 GenPept UniProtKB/Swiss-Prot:Q8VII8

Gene LinkOut

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