Cse1l chromosome segregation 1 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cse1lprovided by MGI
Official Full Name: chromosome segregation 1 likeprovided by MGI
Primary source: MGI:MGI:1339951
See related: Ensembl:ENSMUSG00000002718 AllianceGenome:MGI:1339951
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cas; Xpo2; Capts; 2610100P18Rik
Summary: Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus and protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and skeletal musculature. Orthologous to human CSE1L (chromosome segregation 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 31.9), CNS E11.5 (RPKM 30.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 87.22 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (166747961..166788309)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (166906041..166946389)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

serum phospho-CSE1L is useful for early detecting the efficacy of targeted therapy in initial treatment.
Title: Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts.
CSE1L knockdown reduced Ras-induced metastasis of B16F10 melanoma cells in C57BL/6 mice. v-H-Ras expression altered the cellular trafficking of CSE1L and increased CSE1L secretion.
Title: CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.
Serum cellular apoptosis susceptibility protein may have a role in progression of metastatic colorectal cancer
Title: Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer.
CSE1L/CAS has a role in proliferation and apoptosis [review]
Title: CSE1L/CAS: its role in proliferation and apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125698 (e-PCR)
- UniSTS:162469

BE109633 (e-PCR)
- UniSTS:248310

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear export signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: exportin-2

Names: chromosome segregation 1-like protein; exp2; importin-alpha re-exporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023565.3 → NP_076054.1 exportin-2

See identical proteins and their annotated locations for NP_076054.1

Status: VALIDATED

Source sequence(s)

AL591711, AL591911

Consensus CDS

CCDS17092.1

UniProtKB/Swiss-Prot

Q9ERK4

UniProtKB/TrEMBL

E9Q1T9

Related

ENSMUSP00000002790.8, ENSMUST00000002790.14

Conserved Domains (3) summary

smart00913
Location:29 → 102

IBN_N; Importin-beta N-terminal domain

pfam03378
Location:527 → 962

CAS_CSE1; CAS/CSE protein, C-terminus

pfam08506
Location:156 → 525

Cse1; Cse1