Acat2 acetyl-Coenzyme A acetyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acat2provided by MGI
Official Full Name: acetyl-Coenzyme A acetyltransferase 2provided by MGI
Primary source: MGI:MGI:87871
See related: Ensembl:ENSMUSG00000023832 AllianceGenome:MGI:87871
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcp-1x; Tcp1-rs1
Summary: Predicted to enable acetyl-CoA C-acetyltransferase activity. Involved in positive regulation of intestinal cholesterol absorption. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 65.2), liver adult (RPKM 62.8) and 28 other tissues See more
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Genomic context

Location:: 17 A1; 17 8.73 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (13161929..13179612, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (12943042..12960725, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic Acat2 overexpression promotes systemic cholesterol metabolism and adipose lipid metabolism in mice.
Title: Hepatic Acat2 overexpression promotes systemic cholesterol metabolism and adipose lipid metabolism in mice.
findings provide detailed insights into the role of free cholesterol in LD and adipocyte function and suggest that ACAT inhibitors have potential utility for managing disorders associated with extreme obesity
Title: Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW742799 (e-PCR)
- UniSTS:209269

D17Jcs120 (e-PCR), detects polymorphism
- UniSTS:259259

Tcp1 (e-PCR), detects polymorphism
- UniSTS:144574

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intestinal cholesterol absorption	IDA Inferred from Direct Assay more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acetyl-CoA acetyltransferase, cytosolic

Names: cytosolic acetoacetyl-CoA thiolase; t-complex protein 1, related sequence 1

NP_033364.2

EC 2.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009338.3 → NP_033364.2 acetyl-CoA acetyltransferase, cytosolic

See identical proteins and their annotated locations for NP_033364.2

Status: PROVISIONAL

Source sequence(s)

AK167234

Consensus CDS

CCDS37437.1

UniProtKB/Swiss-Prot

Q3TJY7, Q62292, Q8CAY6, Q96EB7, Q99K88, Q9CYV2

UniProtKB/TrEMBL

Q8R4V3

Related

ENSMUSP00000007005.8, ENSMUST00000007005.14

Conserved Domains (2) summary

PRK05790
Location:8 → 396

PRK05790; putative acyltransferase; Provisional

cd00751
Location:9 → 396

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...