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Nop2 NOP2 nucleolar protein [ Mus musculus (house mouse) ]

Gene ID: 110109, updated on 11-Apr-2024

Summary

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Official Symbol
Nop2provided by MGI
Official Full Name
NOP2 nucleolar proteinprovided by MGI
Primary source
MGI:MGI:107891
See related
Ensembl:ENSMUSG00000038279 AllianceGenome:MGI:107891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nol1; 120kDa; A530002O17
Summary
Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Acts upstream of or within blastocyst formation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; brain ventricular layer; branchial arch; early conceptus; and genitourinary system. Orthologous to human NOP2 (NOP2 nucleolar protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 17.5), liver E14 (RPKM 16.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nop2 in Genome Data Viewer
Location:
6 F2; 6 59.32 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125108829..125121716)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125131883..125144753)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene microRNA 7045 Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene predicted gene, 23751 Neighboring gene STARR-positive B cell enhancer ABC_E9675 Neighboring gene intermediate filament family orphan 1 Neighboring gene STARR-seq mESC enhancer starr_17330 Neighboring gene STARR-positive B cell enhancer ABC_E2207 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The nucleolar protein NOP2 is required for nucleolar maturation and ribosome biogenesis during preimplantation development in mammals. Wang H, et al. FASEB J, 2020 Feb. PMID 31908012
  2. Nop2 is required for mammalian preimplantation development. Cui W, et al. Mol Reprod Dev, 2016 Feb. PMID 26632338, Free PMC Article
  3. Nucleolar protein 1 (Nol1) expression in the mouse brain. Mitrecić D, et al. Coll Antropol, 2008 Jan. PMID 18405070
  4. p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation. Khanna-Gupta A, et al. J Leukoc Biol, 2006 May. PMID 16641140
  5. Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain. Kosi N, et al. Brain Res, 2015 Feb 9. PMID 25481415

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The nucleolar protein NOP2 is required for nucleolar maturation and ribosome biogenesis during preimplantation development in mammals.
    Title: The nucleolar protein NOP2 is required for nucleolar maturation and ribosome biogenesis during preimplantation development in mammals.
  2. results demonstrate that Nop2 is an essential gene for blastocyst formation, and is required for RNA processing and/or stability in vivo during preimplantation embryo development in the mouse.
    Title: Nop2 is required for mammalian preimplantation development.
  3. Findings suggest a newly discovered role of Nop2 in both mature neurons and in cells possibly involved in the regeneration of nervous tissue
    Title: Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain.
  4. Inappropriate expression of the p120 gene can result in aberrant neutrophil maturation.
    Title: p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (cytosine-C5-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable 28S rRNA (cytosine-C(5))-methyltransferase
Names
NOP2 nucleolar protein homolog
nucleolar protein 1, 120 kDa
nucleolar protein 2 homolog
proliferating-cell nucleolar antigen p120
proliferation-associated nucleolar protein p120
putative ribosomal RNA methyltransferase NOP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138747.2 → NP_620086.2  probable 28S rRNA (cytosine-C(5))-methyltransferase

    Status: VALIDATED

    Source sequence(s)
    AI325393, AK079914, BY244994
    Consensus CDS
    CCDS51912.1
    UniProtKB/Swiss-Prot
    Q3U4W9, Q922K7
    UniProtKB/TrEMBL
    E9QN31
    Related
    ENSMUSP00000047123.9, ENSMUST00000044200.11
    Conserved Domains (2) summary
    TIGR00446
    Location:297 → 571
    nop2p; NOL1/NOP2/sun family putative RNA methylase
    PHA03247
    Location:577 → 794
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125108829..125121716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255097.2 → XP_030110957.1  probable 28S rRNA (cytosine-C(5))-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q3U4W9, Q922K7
    UniProtKB/TrEMBL
    E9QN31
    Conserved Domains (2) summary
    TIGR00446
    Location:297 → 571
    nop2p; NOL1/NOP2/sun family putative RNA methylase
    PHA03247
    Location:577 → 794
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922K7.1 GenPept UniProtKB/Swiss-Prot:Q922K7

Gene LinkOut

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