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Dnah12 dynein, axonemal, heavy chain 12 [ Mus musculus (house mouse) ]

Gene ID: 110083, updated on 11-Apr-2024

Summary

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Official Symbol
Dnah12provided by MGI
Official Full Name
dynein, axonemal, heavy chain 12provided by MGI
Primary source
MGI:MGI:107720
See related
Ensembl:ENSMUSG00000021879 AllianceGenome:MGI:107720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHC3; Gm74; HL19; DLP12; Gm284; Gm907; HL-19; Hdhc3; Dnahc3; Dnah12l; Dnahc12; Dnahc7c; Dnahc7l; 4921531P07Rik
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of inner dynein arm. Is expressed in choroid invagination; diencephalon roof plate; metencephalon part of 4th ventricle choroid plexus; olfactory epithelium; and pharynx epithelium. Orthologous to human DNAH12 (dynein axonemal heavy chain 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.7) and lung adult (RPKM 0.5) See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 16.09 cM
Exon count:
77
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26412709..26614250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26691554..26892719)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:27489365-27489548 Neighboring gene ADP-ribosylation factor 4 Neighboring gene phosphodiesterase 12 Neighboring gene microRNA 7672 Neighboring gene predicted gene, 34415 Neighboring gene STARR-seq mESC enhancer starr_36242 Neighboring gene STARR-seq mESC enhancer starr_36244 Neighboring gene ankyrin repeat and SOCS box-containing 14 Neighboring gene predicted gene, 41115 Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Neesen J, et al. Gene, 1997 Oct 24. PMID 9373155
  2. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
  3. Multiple mouse chromosomal loci for dynein-based motility. Vaughan KT, et al. Genomics, 1996 Aug 15. PMID 8812413
  4. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner dynein arm ISM
Inferred from Sequence Model
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 12
Names
axonemal beta dynein heavy chain 12
axonemal dynein heavy chain 12-like protein
axonemal dynein heavy chain 7-like protein
ciliary dynein heavy chain 12
dynein heavy chain 12, axonemal
dynein, axonemal, heavy chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370884.1 → NP_001357813.1  dynein axonemal heavy chain 12

    Status: VALIDATED

    Source sequence(s)
    AC121919, AC133179
    Conserved Domains (6) summary
    COG5245
    Location:891 → 3595
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:676 → 1110
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1238 → 1564
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2246 → 2506
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:2896 → 3112
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:3656 → 3956
    Dynein_C; Dynein heavy chain C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    26412709..26614250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316243.3 → XP_017171732.1  dynein axonemal heavy chain 12 isoform X3

    Related
    ENSMUSP00000022433.6, ENSMUST00000022433.12
    Conserved Domains (6) summary
    COG5245
    Location:891 → 3595
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:676 → 1110
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1238 → 1564
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2246 → 2506
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:2896 → 3112
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:3656 → 3956
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_017316242.2 → XP_017171731.1  dynein axonemal heavy chain 12 isoform X2

    UniProtKB/TrEMBL
    E9QPU2
    Conserved Domains (7) summary
    pfam12777
    Location:2472 → 2575
    MT; Microtubule-binding stalk of dynein motor
    pfam08393
    Location:676 → 1110
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1238 → 1564
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:1828 → 2006
    AAA_7; P-loop containing dynein motor region D3
    pfam12780
    Location:2199 → 2459
    AAA_8; P-loop containing dynein motor region D4
    pfam17852
    Location:1684 → 1819
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    pfam17857
    Location:2039 → 2135
    AAA_lid_1; AAA+ lid domain

  3. XM_017316241.1 → XP_017171730.1  dynein axonemal heavy chain 12 isoform X1

    UniProtKB/TrEMBL
    E9QPU2
    Conserved Domains (8) summary
    pfam12777
    Location:2519 → 2622
    MT; Microtubule-binding stalk of dynein motor
    pfam08393
    Location:676 → 1110
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1238 → 1564
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:1875 → 2053
    AAA_7; P-loop containing dynein motor region D3
    pfam12780
    Location:2246 → 2506
    AAA_8; P-loop containing dynein motor region D4
    pfam17852
    Location:1731 → 1866
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    pfam17857
    Location:2086 → 2182
    AAA_lid_1; AAA+ lid domain
    cl38936
    Location:1552 → 1695
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_001781207.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V0Q1.2 GenPept UniProtKB/Swiss-Prot:Q3V0Q1

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