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Dut deoxyuridine triphosphatase [ Mus musculus (house mouse) ]

Gene ID: 110074, updated on 5-Mar-2024

Summary

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Official Symbol
Dutprovided by MGI
Official Full Name
deoxyuridine triphosphataseprovided by MGI
Primary source
MGI:MGI:1346051
See related
Ensembl:ENSMUSG00000027203 AllianceGenome:MGI:1346051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dutp; dUTPase; D2Bwg0749e; 5031412I06Rik; 5133400F09Rik
Summary
Predicted to enable several functions, including dUTP diphosphatase activity; magnesium ion binding activity; and peroxisome proliferator activated receptor binding activity. Predicted to be involved in pyrimidine deoxyribonucleotide metabolic process and regulation of protein-containing complex assembly. Located in mitochondrion. Is expressed in central nervous system and retina. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 32.2), liver E14 (RPKM 31.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dut in Genome Data Viewer
Location:
2 F1; 2 61.33 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125089168..125100969)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125247248..125259049)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 1 Neighboring gene predicted gene, 46760 Neighboring gene predicted gene 14002 Neighboring gene STARR-seq mESC enhancer starr_05586 Neighboring gene STARR-positive B cell enhancer mm9_chr2:125073047-125073348 Neighboring gene STARR-seq mESC enhancer starr_05587 Neighboring gene STARR-seq mESC enhancer starr_05588 Neighboring gene fibrillin 1 Neighboring gene STARR-seq mESC enhancer starr_05589 Neighboring gene centrosomal protein 152 Neighboring gene 60S ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality. Pálinkás HL, et al. Biomolecules, 2019 Apr 4. PMID 30987342, Free PMC Article
  2. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. Koehler SE, et al. Mol Pharmacol, 2004 Sep. PMID 15322254
  3. Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. Webley SD, et al. Br J Cancer, 2000 Sep. PMID 10952785, Free PMC Article
  4. Cloning and expression of the mouse deoxyuridine triphosphate nucleotidohydrolase gene: differs from the rat enzyme in that it lacks nuclear receptor interacting LXXLL motif. Kan L, et al. Gene Expr, 1999. PMID 10794525, Free PMC Article
  5. Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase. Ladner RD, et al. J Biol Chem, 1996 Mar 29. PMID 8631816

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dUTPase is essential for embryonic development since early dut -/- embryos die shortly after implantation. dut +/- animals are viable while having decreased dUTPase levels.
    Title: CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality.
  2. Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
    Title: Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dUTP diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables pyrimidine deoxyribonucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dTMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in dUMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dUTP catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
deoxyuridine 5'-triphosphate nucleotidohydrolase
Names
deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
NP_001153118.1
NP_076084.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159646.1 → NP_001153118.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1

    See identical proteins and their annotated locations for NP_001153118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK135438, AK153285
    Consensus CDS
    CCDS50695.1
    UniProtKB/TrEMBL
    Q8VCG1, Q9CQ43
    Related
    ENSMUSP00000080767.8, ENSMUST00000082122.14
    Conserved Domains (1) summary
    cl00493
    Location:61 → 198
    trimeric_dUTPase; Trimeric dUTP diphosphatases

  2. NM_023595.6 → NP_076084.2  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2

    See identical proteins and their annotated locations for NP_076084.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK077244, AK153285
    Consensus CDS
    CCDS16675.1
    UniProtKB/Swiss-Prot
    Q8VCG1, Q9CQ43, Q9JJ44
    Related
    ENSMUSP00000057854.9, ENSMUST00000051605.9
    Conserved Domains (1) summary
    cl00493
    Location:23 → 160
    trimeric_dUTPase; Trimeric dUTP diphosphatases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    125089168..125100969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ43.1 GenPept UniProtKB/Swiss-Prot:Q9CQ43

Gene LinkOut

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