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Dek DEK proto-oncogene [ Mus musculus (house mouse) ]

Gene ID: 110052, updated on 21-Apr-2024

Summary

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Official Symbol
Dekprovided by MGI
Official Full Name
DEK proto-oncogeneprovided by MGI
Primary source
MGI:MGI:1926209
See related
Ensembl:ENSMUSG00000021377 AllianceGenome:MGI:1926209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D13H6S231E; 1810019E15Rik
Summary
Predicted to enable histone binding activity. Acts upstream of or within regulation of double-strand break repair via nonhomologous end joining. Located in contractile fiber and nucleus. Is expressed in several structures, including early conceptus; limb; liver; oocyte; and retina. Orthologous to human DEK (DEK proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 94.0), liver E14.5 (RPKM 74.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 24.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (47238243..47261134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (47084767..47107530, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 4B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1875 Neighboring gene thiopurine methyltransferase Neighboring gene lysine (K)-specific demethylase 1B Neighboring gene STARR-seq mESC enhancer starr_34433 Neighboring gene predicted gene, 40935 Neighboring gene STARR-seq mESC enhancer starr_34434 Neighboring gene ring finger protein 144B Neighboring gene RIKEN cDNA A930002C04 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK. Song Y, et al. Int Immunopharmacol, 2022 Nov. PMID 36115279
  2. Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis. Cao J, et al. Mol Pharm, 2021 Jan 4. PMID 33253580
  3. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Pease NA, et al. Cancers (Basel), 2020 Jul 17. PMID 32708944, Free PMC Article
  4. Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit. Yue L, et al. Dev Cell, 2020 Jun 22. PMID 32502396
  5. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Serrano-Lopez J, et al. Exp Hematol, 2018 Mar. PMID 29288703, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma.
    Title: DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma.
  2. miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK.
    Title: miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK.
  3. Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis.
    Title: Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis.
  4. Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
    Title: Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
  5. Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
    Title: Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
  6. Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
    Title: Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
  7. These findings define DEK as an important and multifunctional mediator of homologous recombination.
    Title: DEK is required for homologous recombination repair of DNA breaks.
  8. DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy.
    Title: DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis.
  9. DEK was expressed throughout the brain in both sexes, including the medial prefrontal cortex (prelimbic, infralimbic and dorsal peduncular). DEK was also abundant in all amygdalar subdivisions (basolateral, central and medial) and in the hippocampus including the CA1, CA2, CA3, dentate gyrus (DG), ventral subiculum and entorhinal cortex.
    Title: Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice.
  10. Dek contributes to esophageal squamous cell carcinoma tumorigenesis at least partially through keratinocyte intrinsic pathways which promote cellular and tumor growth.
    Title: Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell quiescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase I NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of B-WICH complex ISO
Inferred from Sequence Orthology
more info
  
located_in contractile muscle fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein DEK
Names
DEK oncogene (DNA binding)
DEK proto-oncogene (DNA binding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025900.2 → NP_080176.2  protein DEK

    See identical proteins and their annotated locations for NP_080176.2

    Status: VALIDATED

    Source sequence(s)
    AK033451, AK141790, AV449751, BU920290, BY429959
    Consensus CDS
    CCDS26490.1
    UniProtKB/Swiss-Prot
    Q7TNV0, Q80VC5, Q8BZV6
    Related
    ENSMUSP00000021807.7, ENSMUST00000021807.13
    Conserved Domains (2) summary
    smart00513
    Location:153 → 187
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:325 → 379
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    47238243..47261134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157833.1 → XP_036013726.1  protein DEK isoform X1

    UniProtKB/Swiss-Prot
    Q7TNV0, Q80VC5, Q8BZV6
    Conserved Domains (2) summary
    smart00513
    Location:153 → 187
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:325 → 379
    DEK_C; DEK C terminal domain

RNA

  1. XR_382230.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNV0.1 GenPept UniProtKB/Swiss-Prot:Q7TNV0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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