SLC27A2 solute carrier family 27 member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC27A2provided by HGNC
Official Full Name: solute carrier family 27 member 2provided by HGNC
Primary source: HGNC:HGNC:10996
See related: Ensembl:ENSG00000140284 MIM:603247; AllianceGenome:HGNC:10996
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VLCS; FATP2; VLACS; ACSVL1; FACVL1; hFACVL1; HsT17226
Summary: The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Expression: Biased expression in liver (RPKM 63.2), kidney (RPKM 62.8) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q21.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (50182196..50236385)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (47990417..48044633)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (50474393..50528582)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1.
Title: FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1.
Feedback loop between fatty acid transport protein 2 and receptor interacting protein 3 pathways promotes polymorphonuclear neutrophil myeloid-derived suppressor cells-potentiated suppressive immunity in bladder cancer.
Title: Feedback loop between fatty acid transport protein 2 and receptor interacting protein 3 pathways promotes polymorphonuclear neutrophil myeloid-derived suppressor cells-potentiated suppressive immunity in bladder cancer.
Upregulated SLC27A2/FATP2 in differentiated thyroid carcinoma promotes tumor proliferation and migration.
Title: Upregulated SLC27A2/FATP2 in differentiated thyroid carcinoma promotes tumor proliferation and migration.
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Title: Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
mouse and human polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) exclusively upregulate fatty acid transport protein 2 (FATP2); FATP2 mediates the acquisition of immunosuppressive activity by PMN-MDSCs and represents a target to inhibit the functions of PMN-MDSCs selectively and to improve the efficiency of cancer therapy
Title: Fatty acid transport protein 2 reprograms neutrophils in cancer.
In overweight/obese pregnancies, the increased FATP2 placental expression could contribute to increased fatty acid delivery to the fetus.
Title: Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women.
In mice Grassofermata decreased absorption of (13)C-oleate demonstrating its potential as a therapeutic agent.
Title: Fatty acid transport protein-2 inhibitor Grassofermata/CB5 protects cells against lipid accumulation and toxicity.
Protective effects of breastfeeding are reflected in higher expression levels of SLC27A2, FASN, PPARalpha and INSR in blood cells.
Title: Influence of breastfeeding on blood-cell transcript-based biomarkers of health in children.
these data support the conclusion that FATP2 has a dual function in the pathways linking the transport and activation of exogenous fatty acids.
Title: Overexpression of human fatty acid transport protein 2/very long chain acyl-CoA synthetase 1 (FATP2/Acsvl1) reveals distinct patterns of trafficking of exogenous fatty acids.
even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth.
Title: The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BP230006B20H5 (e-PCR)
- UniSTS:519207

D15S1254 (e-PCR)
- UniSTS:40083

D15S918 (e-PCR)
- UniSTS:50383

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables arachidonate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables cholate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	TAS Traceable Author Statement more info
enables oleate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables phytanate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables phytanate-CoA ligase activity	TAS Traceable Author Statement more info
enables pristanate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables pristanate-CoA ligase activity	TAS Traceable Author Statement more info
enables very long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in bile acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid biosynthetic process	TAS Traceable Author Statement more info
involved_in bile acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid alpha-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid alpha-oxidation	TAS Traceable Author Statement more info
involved_in fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty-acyl-CoA biosynthetic process	TAS Traceable Author Statement more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of long-chain fatty acid import into cell	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in methyl-branched fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in very long-chain fatty acid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in specific granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: long-chain fatty acid transport protein 2

Names: FATP-2; THCA-CoA ligase; arachidonate--CoA ligase; fatty acid transport protein 2; fatty-acid-coenzyme A ligase, very long-chain 1; long-chain-fatty-acid--CoA ligase; phytanate--CoA ligase; solute carrier family 27 (fatty acid transporter), member 2; very long-chain acyl-CoA synthetase; very long-chain fatty-acid-coenzyme A ligase 1; very long-chain-fatty-acid-CoA ligase

NP_001153101.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

EC 6.2.1.7

NP_003636.2

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

EC 6.2.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159629.2 → NP_001153101.1 long-chain fatty acid transport protein 2 isoform 2

See identical proteins and their annotated locations for NP_001153101.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is lacking an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment compared to isoform 1.

Source sequence(s)

AK290262, BC057770, BM980042

Consensus CDS

CCDS53943.1

UniProtKB/TrEMBL

Q53GS2

Related

ENSP00000370289.4, ENST00000380902.8

Conserved Domains (2) summary

cl17068
Location:76 → 557

AFD_class_I; Adenylate forming domain, Class I superfamily

cl27678
Location:47 → 98

AMP-binding; AMP-binding enzyme
NM_003645.4 → NP_003636.2 long-chain fatty acid transport protein 2 isoform 1

See identical proteins and their annotated locations for NP_003636.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).

Source sequence(s)

AK223145, AK290262

Consensus CDS

CCDS10133.1

UniProtKB/Swiss-Prot

A8K2J7, O14975, Q53FY6, Q6PF09

UniProtKB/TrEMBL

Q53GS2

Related

ENSP00000267842.5, ENST00000267842.10

Conserved Domains (1) summary

cd05938
Location:74 → 610

hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins