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Art3 ADP-ribosyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 109979, updated on 5-Mar-2024

Summary

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Official Symbol
Art3provided by MGI
Official Full Name
ADP-ribosyltransferase 3provided by MGI
Primary source
MGI:MGI:1202729
See related
Ensembl:ENSMUSG00000034842 AllianceGenome:MGI:1202729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTC3; 4930569O04Rik
Summary
Predicted to enable NAD+ ADP-ribosyltransferase activity. Predicted to be involved in peptidyl-arginine ADP-ribosylation. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Is expressed in facial ganglion; glossopharyngeal ganglion; and vestibulo-cochlear ganglion. Orthologous to human ART3 (ADP-ribosyltransferase 3 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 97.0), testis adult (RPKM 41.5) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E2; 5 46.54 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92479659..92562487)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92331799..92414628)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene predicted gene, 23031 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92777801-92778102 Neighboring gene STARR-seq mESC enhancer starr_13640 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene STARR-positive B cell enhancer ABC_E6346 Neighboring gene chemokine (C-X-C motif) ligand 11 Neighboring gene CWF19-like 1, cell cycle control pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4766 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92864208-92864361 Neighboring gene nucleoporin 54 Neighboring gene predicted gene, 42114 Neighboring gene scavenger receptor class B, member 2 Neighboring gene microRNA 6415

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene. Friedrich M, et al. Biochim Biophys Acta, 2006 Jun. PMID 16934346
  2. Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements. Zhang Y, et al. PLoS Genet, 2008 Feb 29. PMID 18454193, Free PMC Article
  3. WECHE: a novel hematopoietic regulatory factor. Ohneda O, et al. Immunity, 2000 Feb. PMID 10714680
  4. The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing. Abe K, et al. EMBO J, 2015 Jun 3. PMID 25896510, Free PMC Article
  5. DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities. Martinez ME, et al. JCI Insight, 2022 Nov 8. PMID 36166296, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ecto-ADP-ribosyltransferase 3
Names
ADP-ribosyltransferase C2 and C3 toxin-like 3
ART3 mono(ADP-ribosyl)transferase
NAD(P)(+)--arginine ADP-ribosyltransferase 3
mono(ADP-ribosyl)transferase 3
NP_001297593.1
NP_001297594.1
NP_001357520.1
NP_859417.2
XP_006534769.1
XP_006534770.1
XP_006534771.1
XP_006534772.1
XP_006534773.1
XP_006534774.1
XP_006534775.1
XP_006534776.1
XP_006534777.1
XP_006534779.1
XP_006534781.1
XP_006534782.1
XP_006534783.1
XP_006534784.1
XP_030109908.1
XP_030109909.1
XP_030109910.1
XP_030109911.1
XP_030109912.1
XP_030109913.1
XP_030109914.1
XP_036020621.1
XP_036020622.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310664.1 → NP_001297593.1  ecto-ADP-ribosyltransferase 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001297593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122365, AK016257, AW123431
    Consensus CDS
    CCDS80328.1
    UniProtKB/TrEMBL
    B7ZNM3, E9QNU1
    Related
    ENSMUSP00000113510.2, ENSMUST00000121096.8
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  2. NM_001310665.1 → NP_001297594.1  ecto-ADP-ribosyltransferase 3 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001297594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a shorter 5' UTR, lacks three alternate in-frame exons, and contains an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC122365
    Consensus CDS
    CCDS84904.1
    UniProtKB/TrEMBL
    B7ZNM3
    Related
    ENSMUSP00000112648.2, ENSMUST00000119587.8
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  3. NM_001370591.1 → NP_001357520.1  ecto-ADP-ribosyltransferase 3 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122365
    UniProtKB/Swiss-Prot
    B2RUC2, O54738, Q8R2F9, Q8R2G0, Q8R2G1, Q8R2G2, Q8R2G3, Q8R2G4
    UniProtKB/TrEMBL
    B7ZNM3
    Related
    ENSMUSP00000114083.2, ENSMUST00000118106.8
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  4. NM_181728.3 → NP_859417.2  ecto-ADP-ribosyltransferase 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_859417.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a shorter 5' UTR and lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC122365
    Consensus CDS
    CCDS51546.1
    UniProtKB/TrEMBL
    B7ZNM3
    Related
    ENSMUSP00000113074.2, ENSMUST00000120193.8
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    92479659..92562487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534707.4 → XP_006534770.1  ecto-ADP-ribosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006534770.1

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  2. XM_006534708.4 → XP_006534771.1  ecto-ADP-ribosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006534771.1

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  3. XM_006534712.4 → XP_006534775.1  ecto-ADP-ribosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006534775.1

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  4. XM_030254048.1 → XP_030109908.1  ecto-ADP-ribosyltransferase 3 isoform X5

    UniProtKB/Swiss-Prot
    B2RUC2, O54738, Q8R2F9, Q8R2G0, Q8R2G1, Q8R2G2, Q8R2G3, Q8R2G4
    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  5. XM_030254051.2 → XP_030109911.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    B7ZNM3
    Related
    ENSMUSP00000108706.3, ENSMUST00000113083.9
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  6. XM_030254052.2 → XP_030109912.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  7. XM_030254054.2 → XP_030109914.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  8. XM_030254053.1 → XP_030109913.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  9. XM_006534710.2 → XP_006534773.1  ecto-ADP-ribosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006534773.1

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  10. XM_036164729.1 → XP_036020622.1  ecto-ADP-ribosyltransferase 3 isoform X10

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  11. XM_006534706.3 → XP_006534769.1  ecto-ADP-ribosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006534769.1

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  12. XM_006534713.4 → XP_006534776.1  ecto-ADP-ribosyltransferase 3 isoform X2

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  13. XM_006534714.4 → XP_006534777.1  ecto-ADP-ribosyltransferase 3 isoform X3

    See identical proteins and their annotated locations for XP_006534777.1

    UniProtKB/TrEMBL
    B7ZNM3, E9QNU1
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  14. XM_030254050.1 → XP_030109910.1  ecto-ADP-ribosyltransferase 3 isoform X6

    UniProtKB/TrEMBL
    A0A0R4J1Q4
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  15. XM_006534718.4 → XP_006534781.1  ecto-ADP-ribosyltransferase 3 isoform X7

    See identical proteins and their annotated locations for XP_006534781.1

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  16. XM_006534716.4 → XP_006534779.1  ecto-ADP-ribosyltransferase 3 isoform X4

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  17. XM_006534719.4 → XP_006534782.1  ecto-ADP-ribosyltransferase 3 isoform X8

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  18. XM_006534721.5 → XP_006534784.1  ecto-ADP-ribosyltransferase 3 isoform X11

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  19. XM_006534720.4 → XP_006534783.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  20. XM_006534711.5 → XP_006534774.1  ecto-ADP-ribosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006534774.1

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  21. XM_030254049.2 → XP_030109909.1  ecto-ADP-ribosyltransferase 3 isoform X5

    UniProtKB/Swiss-Prot
    B2RUC2, O54738, Q8R2F9, Q8R2G0, Q8R2G1, Q8R2G2, Q8R2G3, Q8R2G4
    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  22. XM_006534709.5 → XP_006534772.1  ecto-ADP-ribosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006534772.1

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  23. XM_036164728.1 → XP_036020621.1  ecto-ADP-ribosyltransferase 3 isoform X7

    UniProtKB/TrEMBL
    B7ZNM3
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2G4.2 GenPept UniProtKB/Swiss-Prot:Q8R2G4

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